The MDC Mission

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) carries out basic biomedical research with the aim of understanding the molecular basis of health and disease, and translating these findings as quickly as possible into clinical application. The research involves the diagnosis and treatment of diseases, as well as their prevention.

Research Highlights

New brick in PKA Legoland adds complexity to a picture we thought we knew well

Protein Kinase A (PKA) is a protein that enjoys enough fame to be sketched by young biochemists listening to lectures about how it is regulated. The fundamental kinase is present throughout the body with a role in countless processes. It's easy to think PKA is so well studied that we know everything about it, but scientists at the MDC have found a new layer of PKA regulation which was published this week in Nature Communications.


The life cycle of proteins

Some proteins behave in an unusual way: the older they become, the more stable they are. A research team at the MDC has now published this surprising finding in the journal Cell. Their work has traced the life cycle of thousands of proteins from synthesis to disposal. The results are relevant for diseases where there are surplus copies of certain genes.


Further research highlights


Three new guest scientists foster research at MDC and BIH

Excellent new people at the MDC: The Charité Foundation and the Einstein Foundation of Berlin are supporting three professors who will come to Berlin to collaborate with MDC groups under the framework of the BIH. The support is part of the BIH strategy to bring findings from basic research more quickly into clinical practice.


Genome editing: efficient CRISPR experiments in mouse cells

The new program “CrispRGold” program helps scientists to identify the most effective and specific RNA sequences for use genome editing experiments. It has been devised by a group of researchers headed by Prof. Klaus Rajewsky and is now described in the journal PNAS. The team has also developed a new mouse model that already carries the Cas9 protein.


BIMSB boosts cancer research with new research group on “Evolutionary and Cancer Genomics” headed by Roland Schwarz

Bioinformatician Roland Schwarz has been lead investigator of the new BIMSB junior research group on “Evolutionary and Cancer Genomics” since October 2016. Schwarz wants his work, particularly in the area of cancer research, to contribute towards ensuring that diseases are diagnosed earlier and treated more effectively.


Further news on MDC Insights