Publications



2017

Oz S.; Pankonien I.; Belkacemi A.; Flockerzi V.; Klussmann E.; Haase H.; Dascal N.
Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the {alpha}1C subunit
Journal of Physiology : (2017-02-14)



Dworatzek Elke; Mahmoodzadeh S.
Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system
Pharmacological Research : (2017-01-21)



Duft K.; Schanz M.; Pham H.; Abdelwahab A.; Schriever C.; Kararigas G.; Dworatzek E.; Davidson M.M.; Regitz-Zagrosek V.; Morano I.; Mahmoodzadeh S.
17{beta}-estradiol-induced interaction of estrogen receptor {alpha} and human atrial essential myosin light chain modulates cardiac contractile function
Basic Research in Cardiology 112 (1): 1 (2017-01)



2016

Mahmoodzadeh S.; Haase H.; Sporbert A.; Rharass T.; Panakova D.; Morano I.
Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17{beta}-estradiol
Journal of Molecular and Cellular Cardiology 97: 226-234 (2016-08)



Lodka D.; Pahuja A.; Geers-Knoerr C.; Scheibe R.; Nowak M.; Hamati J.; Koehncke C.; Purfuerst B.; Kanashova T.; Schmidt S.; Glass D.J.; Morano I.; Heuser A.; Kraft T.; Bassel-Duby R.; Olson E.N.; Dittmar G.; Sommer T.; Fielitz J.
Muscle RING-finger 2 and 3 maintain striated-muscle structure and function
Journal of Cachexia Sarcopenia and Muscle 7 (2): 165-180 (2016-05)



Chagin V.O.; Casas-Delucchi C.S.; Reinhart M.; Schermelleh L.; Markaki Y.; Maiser A.; Bolius J.J.; Bensimon A.; Fillies M.; Domaing P.; Rozanov Y.M.; Leonhardt H.; Cardoso M.C.
4D visualization of replication foci in mammalian cells corresponding to individual replicons
Nature Communications 7: 11231 (2016-04-07)



Schuster I.; Mahmoodzadeh S.; Dworatzek E.; Jaisser F.; Messaoudi S.; Morano I.; Regitz-Zagrosek V.
Cardiomyocyte-specific overexpression of estrogen receptor beta improves survival and cardiac function after myocardial infarction in female and male mice
Clinical Science 130 (5): 365-376 (2016-01-26)



Morano I.
The contractile apparatus of the heart
Congenital Heart Diseases: The Broken Heart : Clinical Features, Human Genetics and Molecular Pathways : 237-250 (2016)



2015

Lamounier-Zepter V.; Look C.; Schunck W.H.; Schlottmann I.; Woischwill C.; Bornstein S.R.; Xu A.; Morano I.
Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility
International Journal of Obesity 39 (5): 755-761 (2015-05)



Brodarac A.; Saric T.; Oberwallner B.; Mahmoodzadeh S.; Neef K.; Albrecht J.; Burkert K.; Oliverio M.; Nguemo F.; Choi Y.H.; Neiss W.F.; Morano I.; Hescheler J.; Stamm C.
Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation
Stem Cell Research & Therapy 6 (1): 83 (2015-04-23)



Kusch A.; Schmidt M.; Guergen D.; Postpieszala D.; Catar R.; Hegner B.; Davidson M.M.; Mahmoodzadeh S.; Dragun D.
17{beta}-estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling
PLoS ONE 10 (4): e0123385 (2015-04-16)



2014

Lossie J.; Koehncke C.; Mahmoodzadeh S.; Steffen W.; Canepari M.; Maffei M.; Taube M.; Larcheveque O.; Baumert P.; Haase H.; Bottinelli R.; Regitz-Zagrosek V.; Morano I.
Molecular mechanism regulating myosin and cardiac functions by ELC
Biochemical and Biophysical Research Communications 450 (1): 464-469 (2014-07-18)



Petzhold D.; Simsek B.; Meissner R.; Mahmoodzadeh S.; Morano I.
Distinct interactions between actin and essential myosin light chain isoforms
Biochemical and Biophysical Research Communications 449 (3): 284-288 (2014-07-04)



Rozmaritsa N.; Christ T.; Van Wagoner D.R.; Haase H.; Stasch J.P.; Matschke K.; Ravens U.
Attenuated response of ICa,L to nitric oxide in atrial fibrillation
Cardiovascular Research 101 (3): 533-542 (2014-03-01)



Mahmoodzadeh S.; Leber J.; Zhang X.; Jaisser F.; Messaoudi S.; Morano I.; Furth P.A.; Dworatzek E.; Regitz-Zagrosek V.
Cardiomyocyte-specific estrogen receptor alpha increases angiogenesis, lymphangiogenesis and reduces fibrosis in the female mouse heart post-myocardial infarction
Journal of Cell Science & Therapy 5 (1): 153 (2014-01-30)



2013

Haase N.; Herse F.; Spallek B.; Haase H.; Morano I.; Qadri F.; Szijarto I.A.; Rohm I.; Yilmaz A.; Warrington J.P.; Ryan M.J.; Gollasch M.; Mueller D.N.; Dechend R.; Wallukat G.
Amyloid-{beta} peptides activate {alpha}1-adrenergic cardiovascular receptors
Hypertension 62 (5): 966-972 (2013-11)



Han Y.; Yu G.; Sarioglu H.; Caballero-Martinez A.; Schlott F.; Ueffing M.; Haase H.; Peschel C.; Krackhardt A.M.
Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity
Journal of Proteomics 78: 72-82 (2013-01-14)



2012

Weiss S.; Keren-Raifman T.; Oz S.; Ben Mocha A.; Haase H.; Dascal N.
Modulation of distinct isoforms of L-type calcium channels by Gq-coupled receptors in Xenopus oocytes: Antagonistic effects of G{beta}{gamma} and protein kinase C
Channels 6 (6): 426-437 (2012-11-01)



Pankonien I.; Otto A.; Dascal N.; Morano I.; Haase H.
Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cav{beta}(2)
Biochemical and Biophysical Research Communications 421 (2): 184-189 (2012-05-04)



Lossie J.; Ushakov D.S.; Ferenczi M.A.; Werner S.; Keller S.; Haase H.; Morano I.
Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting
Cardiovascular Research 93 (3): 390-396 (2012-03-01)



Bal M.S.; Castro V.; Piontek J.; Rueckert C.; Walter J.K.; Shymanets A.; Kurig B.; Haase H.; Nuernberg B.; Blasig I.E.
The hinge region of the scaffolding protein of cell contacts, zonula occludens protein 1, regulates interacting with various signaling proteins
Journal of Cellular Biochemistry 113 (3): 934-945 (2012-03)



Alvarez Gonzalez J.; Haase H.; Vassort G.; Morano I.
Impaired modulation of the cardiac L-type Ca2+ channel activity by ahnak-1 after myocardial infarction
Revista Cubana de Cardiologia y Cirugia Cardiovascular 18 (3): 142-148 (2012)



Carnevale D.; Vecchione C.; Mascio G.; Esposito G.; Cifelli G.; Martinello K.; Landolfi A.; Selvetella G.; Grieco P.; Damato A.; Franco E.; Haase H.; Maffei A.; Ciraolo E.; Fucile S.; Frati G.; Mazzoni O.; Hirsch E.; Lembo G.
PI3k{gamma} inhibition reduces blood pressure by a vasorelaxant Akt/LTCC mechanism
Cardiovascular Research 93 (1): 200-209 (2012-01-01)



2011

Zacharias U.; Purfuerst B.; Schoewel V.; Morano I.; Spuler S.; Haase H.
Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release
Journal of Muscle Research and Cell Motility 32 (4-5): 271-280 (2011-12)



Petzhold D.; da Costa-Goncalves A.C.; Gross V.; Morano I.
Spinophilin is required for normal morphology, Ca(2+) homeostasis and contraction but dispensable for beta-adrenergic stimulation of adult cardiomyocytes
Journal of Muscle Research and Cell Motility 32 (4-5): 243-248 (2011-12)



Pankonien I.; Alvarez J.L.; Doller A.; Koehncke C.; Rotte D.; Regitz-Zagrosek V.; Morano I.; Haase H.
Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity
Journal of Muscle Research and Cell Motility 32 (4-5): 281-290 (2011-12)



Look C.; Morano I.; Ehrhart-Bornstein M.; Bornstein S.R.; Lamounier-Zepter V.
BMS309403 directly suppresses cardiac contractile function
Naunyn Schmiedebergs Archives of Pharmacology 384 (3): 255-263 (2011-09)



Laettig-Tuennemann G.; Prinz M.; Hoffmann D.; Behlke J.; Palm-Apergi C.; Morano I.; Herce H.D.; Cardoso M.C.
Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
Nature Communications 2: 453 (2011-08-30)



Hoppmann C.; Schmieder P.; Domaing P.; Vogelreiter G.; Eichhorst J.; Wiesner B.; Morano I.; Rueck-Braun K.; Beyermann M.
Photocontrol of contracting muscle fibers
Angewandte Chemie International Edition 50 (33): 7699-7702 (2011-08-08)



Wenzel K.; Rajakumar A.; Haase H.; Geusens N.; Hubner N.; Schulz H.; Brewer J.; Roberts L.; Hubel C.A.; Herse F.; Hering L.; Qadri F.; Lindschau C.; Wallukat G.; Pijnenborg R.; Heidecke H.; Riemekasten G.; Luft F.C.; Muller D.N.; Lamarca B.; Dechend R.
Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats
Hypertension 58 (1): 77-84 (2011-07)



Petzhold D.; Lossie J.; Keller S.; Werner S.; Haase H.; Morano I.
Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity
Cardiovascular Research 90 (3): 513-520 (2011-06-01)



Christian F.; Szaszak M.; Friedl S.; Drewianka S.; Lorenz D.; Goncalves A.; Furkert J.; Vargas C.; Schmieder P.; Goetz F.; Zuehlke K.; Moutty M.; Goettert H.; Joshi M.; Reif B.; Haase H.; Morano I.; Grossmann S.; Klukovits A.; Verli J.; Gaspar R.; Noack C.; Bergmann M.; Kass R.; Hampel K.; Kashin D.; Genieser H.G.; Herberg F.W.; Willoughby D.; Cooper D.M.; Baillie G.S.; Houslay M.D.; von Kries J.P.; Zimmermann B.; Rosenthal W.; Klussmann E.
Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes
Journal of Biological Chemistry 286 (11): 9079-9096 (2011-03-18)



Siegert R.; Perrot A.; Keller S.; Behlke J.; Michalewska-Wludarczyk A.; Wycisk A.; Tendera M.; Morano I.; Oezcelik C.
A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties
Biochemical and Biophysical Research Communications 405 (3): 473-479 (2011-02-18)



Look C.; Morano I.; Ehrhart-Bornstein M.; Bornstein S.R.; Lamounier-Zepter V.
Adipocyte-derived factors suppress heart contraction
International Journal of Obesity 35 (1): 84-90 (2011-01)



2010

Marg A.; Haase H.; Neumann T.; Kouno M.; Morano I.
AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness
Biochemical and Biophysical Research Communications 401 (1): 143-148 (2010-10-08)



Alvarez J.L.; Petzhold D.; Pankonien I.; Behlke J.; Kouno M.; Vassort G.; Morano I.; Haase H.
Ahnak1 modulates L-type Ca(2+) channel inactivation of rodent cardiomyocytes
Pfluegers Archiv European Journal of Physiology 460 (4): 719-730 (2010-09)



Petzhold D.; Lossie J.; Behlke J.; Keller S.; Haase H.; Morano I.
Auto-inhibitory effects of an IQ motif on protein structure and function
Biochemical and Biophysical Research Communications 396 (4): 939-943 (2010-06-11)



Karczewski P.; Haase H.; Hempel P.; Bimmler M.
Agonistic antibody to the alpha(1)-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa protein
Molecular and Cellular Biochemistry 333 (1-2): 233-242 (2010-01)



2009

Panek A.N.; Posch M.G.; Alenina N.; Ghadge S.K.; Erdmann B.; Popova E.; Perrot A.; Geier C.; Dietz R.; Morano I.; Bader M.; Oezcelik C.
Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload
PLoS ONE 4 (8): e6743 (2009-08-25)



Lamounier-Zepter V.; Look C.; Alvarez J.; Christ T.; Ravens U.; Schunck W.H.; Ehrhart-Bornstein M.; Bornstein S.R.; Morano I.
Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction. A new link between obesity and heart disease
Circulation Research 105 (4): 326-334 (2009-08-14)



Ciobanasu C.; Harms E.; Tuennemann G.; Cardoso M.C.; Kubitscheck U.
Cell-penetrating HIV1 TAT peptides float on model lipid bilayers
Biochemistry 48 (22): 4728-4737 (2009-06-09)



Tintu A.; Rouwet E.; Verlohren S.; Brinkmann J.; Ahmad S.; Crispi F.; van Bilsen M.; Carmeliet P.; Staff A.C.; Tjwa M.; Cetin I.; Gratacos E.; Hernandez-Andrade E.; Hofstra L.; Jacobs M.; Lamers W.H.; Morano I.; Safak E.; Ahmed A.; le Noble F.
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences
PLoS ONE 4 (4): e5155 (2009-04-09)



2008

Marg A.; Meyer T.; Vigneron M.; Vinkemeier U.
Microinjected antibodies interfere with protein nucleocytoplasmic shuttling by distinct molecular mechanisms
Cytometry Part A 73A (12): 1128-1140 (2008-12)



Look C.; Morano I.; Lamounier-Zepter V.
Human adipocyte-derived factors directly inhibit cardiac contraction
Journal of Muscle Research and Cell Motility 29 (6-8): 181-184 (2008-12)



Wenzel K.; Haase H.; Wallukat G.; Derer W.; Bartel S.; Homuth V.; Herse F.; Huebner N.; Schulz H.; Janczikowski M.; Lindschau C.; Schroeder C.; Verlohren S.; Morano I.; Mueller D.N.; Luft F.C.; Dietz R.; Dechend R.; Karczewski P.
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension
PLoS ONE 3 (11): e3742 (2008-11-17)



Veninga H.; Becker S.; Hoek R.M.; Wobus M.; Wandel E.; van der Kaa J.; van der Valk M.; de Vos A.F.; Haase H.; Owens B.; van der Poll T.; van Lier R.A.; Verbeek J.S.; Aust G.; Hamann J.
Analysis of CD97 expression and manipulation: Antibody treatment but not gene targeting curtails granulocyte migration
Journal of Immunology 181 (9): 6574-6583 (2008-11-01)



2007

Tuennemann G.; Karczewski P.; Haase H.; Cardoso M.C.; Morano I.
Modulation of muscle contraction by a cell-permeable peptide
Journal of Molecular Medicine 85 (12): 1405-1412 (2007-12)



Carnes C.A.; Janssen P.M.L.; Ruehr M.L.; Nakayama H.; Nakayama T.; Haase H.; Bauer J.A.; Chung M.K.; Fearon I.M.; Gillinov A.M.; Hamlin R.L.; van Wagoner D.R.
Atrial glutathione content, calcium current, and contractility
Journal of Biological Chemistry 282 (38): 28063-28073 (2007-09-21)



Aydt E.M.; Wolff G.; Morano I.
Molecular modeling of the myosin-S1(A1) isoform
Journal of Structural Biology 159 (1): 158-163 (2007-07)



Er F.; Michels G.; Brandt M.C.; Khan I.; Haase H.; Eicks M.; Lindner M.; Hoppe U.C.
Impact of testosterone on cardiac L-type calcium channels and Ca(2+) sparks: Acute actions antagonize chronic effects
Cell Calcium 41 (5): 467-477 (2007-05-01)



Jaiswal J.K.; Marlow G.; Summerill G.; Mahjneh I.; Mueller S.; Hill M.; Miyake K.; Haase H.; Anderson L.V.; Richard I.; Kiuru-Enari S.; McNeil P.L.; Simon S.M.; Bashir R.
Patients with a non-dysferlin Miyoshi myopathy have a novel membrane repair defect
Traffic 8 (1): 77-88 (2007-01)



Arner A.; Scott R.S.; Haase H.; Morano I.; Uvelius B.
Intracellular calcium in hypertrophic smooth muscle from rat urinary bladder
Scandinavian Journal of Urology and Nephrology 41 (4): 270-277 (2007)



Haase H.
Ahnak, a new player in beta-adrenergic regulation of the cardiac L-type Ca(2+) channel
Cardiovascular Research 73 (1): 19-25 (2007-01-01)



2006

Lamounier-Zepter V.; Ehrhart-Bornstein M.; Karczewski P.; Haase H.; Bornstein S.R.; Morano I.
Human adipocytes attenuate cardiomyocyte contraction: characterization of an adipocyte-derived negative inotropic activity
FASEB Journal 20 (10): 1653-1659 (2006-08)



Haase H.; Dobbernack G.; Tuennemann G.; Karczewski P.; Cardoso C.; Petzhold D.; Schlegel W.P.; Lutter S.; Pierschalek P.; Behlke J.; Morano I.
Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats
FASEB Journal 20 (7): 865-873 (2006-05)



Morano I.
Muscle contraction
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1215-1219 (2006)



Morano I.
Heart
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1 : 743-748 (2006)



2005

Patzak A.; Petzhold D.; Wronski T.; Martinka P.; Babu G.J.; Periasamy M.; Haase H.; Morano I.
Constriction velocities of renal afferent and efferent arterioles of mice are not related to SMB expression
Kidney International 68 (6): 2726-2734 (2005-12-01)



Haase H.; Alvarez J.; Petzhold D.; Doller A.; Behlke J.; Erdmann J.; Hetzer R.; Regitz-Zagrosek V.; Vassort G.; Morano I.
Ahnak is critical for cardiac Ca(v)1.2 calcium channel function and its beta-adrenergic regulation
FASEB Journal 19 (14): 1969-1977 (2005-12)



Abdelaziz A.I.; Pagel I.; Schlegel W.P.; Kott M.; Monti J.; Haase H.; Morano I.
Human atrial myosin light chain 1 expression attenuates heart failure
Advances in Experimental Medicine and Biology 565: 283-292 (2005-01-01)



Morano I.
Regulation of smooth muscle contraction
Interventions for Persisting Ductus Arteriosus in the Preterm Infant : 6-11 (2005)



Khalina Y.N.; Bartsch H.; Petzhold D.; Haase H.; Podlubnaya Z.A.; Shpagina M.D.; Morano I.
Reconstitution of ventricular myosin with atrial light chains-1 improves its functional properties
Acta Biochimica Polonica 52 (2): 443-448 (2005-01-01)



Woischwill C.; Karczewski P.; Bartsch H.; Luther H.P.; Kott M.; Haase H.; Morano I.
Regulation of the human atrial myosin light chain 1 promoter by Ca2+-calmodulin-dependent signaling pathways
FASEB Journal 19 (6): 503-511 (2005-01-01)



Luther H.P.; Bartsch H.; Morano I.; Podlowski S.; Baumann G.
Regulation of naturally occurring antisense RNA of myosin heavy chain (MyHC) in neonatal cardiomyocytes
Journal of Cellular Biochemistry 94: 848-855 (2005-01-01)



2004

Haase H.; Pagel I.; Khalina Y.; Zacharzowsky U.; Person V.; Lutsch G.; Petzhold D.; Kott M.; Schaper J.; Morano I.
The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction
FASEB Journal 18 (7): 839-841 (2004-05)



Alvarez J.; Hamplova J.; Hohaus A.; Morano I.; Haase H.; Vassort G.
Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain
Journal of Biological Chemistry 279 (13): 12456-12461 (2004-03-26)



Abdelaziz A.I.; Segaric J.; Bartsch H.; Petzhold D.; Schlegel W.; Kott M.; Seefeldt I.; Klose J.; Bader M.; Haase H.; Morano I.
Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model
Journal of Molecular Medicine 82 (4): 265-274 (2004-01-01)



Bartsch H.; Voigtsberger S.; Baumann G.; Morano I.; Luther H.P.
Detection of a novel sense-antisense RNA-hybrid structure by RACE experiments on endogenous troponin I antisense RNA
RNA 10 (8): 1215-1224 (2004-01-01)



Acosta L.; Haase H.; Morano I.; Moorman A.F.M.; Franco D.
Regional expression of L-type calcium channel subunits during cardiac development
Developmental Dynamics 230 (1): 131-136 (2004-01-01)



Petzhold D.; Bader M.; Bartsch H.; Hohaus A.; Morano I.; Haase H.
Mouse Ahnak (desmoyokin) homologous to human AHNAK [Accession: AY369977 / Locus: AY367634S2 / Organism: Mus musculus (house mouse)]
Nucleotide (GenBank) : (2004-01-01)



2003

Morano I.
Tuning smooth muscle contraction by molecular motors
Journal of Molecular Medicine 81 (8): 481-487 (2003-08)



Iliescu R.; Campos L.A.; Schlegel W.P.; Morano I.; Baltatu O.; Bader M.
Androgen receptor independent cardiovascular action of the antiandrogen flutamide
Journal of Molecular Medicine 81 (7): 420-427 (2003-07)



Schotten U.; Haase H.; Frechen D.; Greiser M.; Stellbrink C.; Vazguez-Jimenez J.F.; Morano I.; Allessie M.A.; Hanrath P.
The L-type Ca2+ channel subunits alpha1c and beta2 are not downregulated in atrial myocardium of patients with chronic atrial fibrillation
Journal of Molecular and Cellular Cardiology 35 (5): 437-443 (2003-05)



Arner A.; Loefgren M.; Morano I.
Smooth, slow and smart muscle motors
Journal of Muscle Research and Cell Motility 24 (2): 165-173 (2003-04)



Loefgren M.; Ekblad E.; Morano I.; Arner A.
Nonmuscle myosin motor of smooth muscle
Journal of General Physiology 121 (4): 301-310 (2003-03-31)



Bosch R.F.; Scherer C.R.; Rueb N.; Woehrl S.; Steinmeyer K.; Haase H.; Busch A.E.; Seipel L.; Kuehlkamp V.
Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces I(Ca,L) and I(to) in rapid atrial pacing in rabbits
Journal of the American College of Cardiology 41 (5): 858-869 (2003-03-05)



Wetzel K.; Baltatu O.; Nafz B.; Persson P.B.; Haase H.; Morano I.
Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats
American Journal of Physiology Regulatory Integrative and Comparative Physiology 284 (2): R607-R610 (2003-02-01)



Lamounier-Zepter V.; Baltas L.G.; Morano I.
Distinct contractile systems for electromechanical and pharmacomechanical coupling in smooth muscle
Advances in Experimental Medicine and Biology 538: 417-425 (2003-01-01)



2002

Gessner C.; Wirtz H.; Sack U.; Winkler J.; Stiehl P.; Schauer J.; Wolff G.
BALF N-acetylglucosaminidase and {beta}-galactosidase activities in idiopathic pulmonary fibrosis
Respiratory Medicine 96 (9): 751-756 (2002-09)



Hohaus A.; Person V.; Behlke J.; Schaper J.; Morano I.; Haase H.
The C-terminal region of ahnak provides a link between cardiac L-type Ca2+ calcium channels and the actin-based cytoskeleton
FASEB Journal 16 (10): 1205-1216 (2002-08)



Zacharzowsky U.B.; Wolff G.; Kott M.; Haase H.; Bartsch H.; Nuessler A.K.; Baltas L.G.; Karawajew L.; Morano I.
Analysis of the energetic state of heart cells after adenovirus-mediated expression of hALC-1
Journal of Cellular Biochemistry 86 (3): 422-431 (2002-06-20)



Serikov V.; Bodi I.; Koch S.E.; Muth J.N.; Mikala G.; Martinov S.G.; Haase H.; Schwartz A.
Mice with cardiac-specific sequestration of the {beta}-subunit of the L-type calcium channel
Biochemical and Biophysical Research Communications 293 (5): 1405-1411 (2002-05-24)



Gompf H.; Luft F.C.; Morano I.
Nitric oxide synthase upregulation and the predelivery blood pressure decrease in spontaneously hypertensive rats
Journal of Hypertension 20: 255-261 (2002-01-01)



Podlowski S.; Bramlage P.; Baumann G.; Morano I.; Luther H.P.
Cardiac troponin I sense-antisense RNA duplexes in the myocardium
Journal of Cellular Biochemistry 85 (1): 198-207 (2002-01-01)



Gessner C.; Liebers U.; Kuhn H.; Stiehl P.; Witt C.; Schauer J.; Wolff G.
BAX and p16INK4A are independent positive prognostic markers for advance tumour stage of nonsmall cell lung cancer
European Respiratory Journal 19: 134-140 (2002-01-01)



2001

Sjuve R.; Haase H.; Ekblad E.; Malmqvist U.; Morano I.; Arner A.
Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder
Cell and Tissue Research 304 (2): 271-278 (2001-01-01)



2000

Hohaus A.; Poteser M.; Romanin C.; Klugbauer N.; Hofmann F.; Morano I.; Haase H.; Groschner K.
Modulation of the smooth-muscle L-type Ca2+ channel alpha1 subunit (alpha1C-b) by the beta2a subunit: a peptide which inhibits binding of beta to the I-II linker of alpha1 induces functional uncoupling
Biochemical Journal 348 (3): 657-665 (2000-06-15)



Morano I.; Chai G.X.; Baltas L.G.; Lamounier-Zepter V.; Lutsch G.; Kott M.; Haase H.; Bader M.
Smooth-muscle contraction without smooth-muscle myosin
Nature Cell Biology 2 (6): 371-375 (2000-06-01)



Reimer D.; Huber I.G.; Garcia M.L.; Haase H.; Striessnig J.
beta Subunit heterogeneity of L-type Ca2+ channels in smooth muscle tissues
FEBS Letters 467 (1): 65-69 (2000-02-04)



Wendel B.; Reinhard R.; Wachtendorf U.; Zacharzowsky U.B.; Osterziel K.J.; Schulte H.D.; Haase H.; Hoehe M.R.; Morano I.
The human beta-myosin heavy chain gene: Sequence diversity and functional characteristics of the protein
Journal of Cellular Biochemistry 79 (4): 566-575 (2000-01-01)



Haase H.; Pfitzmaier B.; McEnery M.W.; Morano I.
Expression of Ca2+ channel subunits during cardiac ontogeny in mice and rats: Identification of fetal alpha1C and beta subunit isoforms
Journal of Cellular Biochemistry 76 (4): 695-703 (2000-01-01)



Morano I.
Modulation of cardiac function by essential myosin light chains in health and disease
Molecular Approaches to Heart Failure Therapy : 285-297 (2000-01-01)



1999

Haase H.; Podzuweit T.; Lutsch G.; Hohaus A.; Kostka S.; Lindschau C.; Kott M.; Kraft R.; Morano I.
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK
FASEB Journal 13 (15): 2161-2172 (1999-12)



Ritter O.; Haase H.; Schulte H.D.; Lange P.E.; Morano I.
Remodeling of the hypertrophied human myocardium by cardiac bHLH transcription factors
Journal of Cellular Biochemistry 74: 551-561 (1999-09-15)



Ritter O.; Luther H.P.; Haase H.; Baltas L.G.; Baumann G.; Schulte H.D.; Morano I.
Expression of atrial myosin light chains but not alpha-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy
Journal of Molecular Medicine 77 (9): 677-685 (1999-09)



Zacharzowsky U.B.; Shah A.M.; Haase H.; Morano I.
Inhibition of crossbridge function in the normal human heart by hypoxic endothelial superfusate
Biochemical and Biophysical Research Communications 262: 64-67 (1999-08-19)



Morano I.
Tuning the human heart molecular motors by myosin light chains
Journal of Molecular Medicine 77: 544-555 (1999-07-01)



Ritter O.; Haase H.; Morano I.
Regulation of Limulus skeletal muscle contraction
FEBS Letters 446: 233-235 (1999-03-12)



Isac C.M.; Ruiz P.; Pfitzmaier B.; Haase H.; Birchmeier W.; Morano I.
Plakoglobin is essential for myocardial compliance but dispensable for myofibril insertion into adherens junctions
Journal of Cellular Biochemistry 72 (1): 8-15 (1999-01-01)



1998

Wetzel U.; Lutsch G.; Haase H.; Ganten U.; Morano I.
Expression of smooth muscle myosin heavy chain B in cardiac vessels of normotensive and hypertensive rats
Circulation Research 83 (2): 204-209 (1998-07-27)



Kott M.; Haberland A.; Zaitsev S.; Buchberger B.; Morano I.; Boettger M.
A new efficient method for transfection of neonatal cardiomyocytes using histone H1 in combination with DOSPER liposomal transfection reagent
Somatic Cell and Molecular Genetics 24 (4): 257-261 (1998-07)



Vance C.L.; Begg C.M.; Lee W.L.; Haase H.; Copeland T.D.; McEnery M.W.
Differential expression and association of calcium channel alpha1B and beta subunits during rat brain ontogeny
Journal of Biological Chemistry 273 (23): 14495-14502 (1998-06-05)



Schaub M.C.; Hefti M.A.; Zuellig R.A.; Morano I.
Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms
Cardiovascular Research 37 (2): 381-404 (1998-02)



Morano M.; Boels P.; Haworth S.G.; Haase H.; Morano I.
Expression and function of atrial myosin light chain 1 in the porcine right ventricle of normal and pulmonary hypertensive animals
Advances in Experimental Medicine and Biology 453: 481-489 (1998)



Gollasch M.; Haase H.; Ried C.; Lindschau C.; Morano I.; Luft F.C.; Haller H.
L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells
FASEB Journal 12: 593-601 (1998-01-01)



Luther H.P.; Haase H.; Hohaus A.; Beckmann G.; Reich J.; Morano I.
Characterization of naturally occurring myosin heavy chain antisense mRNA in rat heart
Journal of Cellular Biochemistry 70: 110-120 (1998-01-01)



Karczewski P.; Hendrischke T.; Wolf W.P.; Morano I.; Bartel S.; Schrader J.
Phosphorylation of phospholamban correlates with relaxation of coronary artery induced by nitric oxide, adenosine, and prostacyclin in the pig
Journal of Cellular Biochemistry 70: 49-59 (1998-01-01)



Wolf W.P.; Spicher K.; Haase H.; Schulze W.
Immunocytochemical localization of the G-protein sub-unit, Goalpha in rat heart. Implications for a role of Goalpha in secretion of cardiac hormones
Journal of Molecular and Cellular Cardiology 30: 1149-1162 (1998-01-01)



1997

Drab M.; Haller H.; Bychkov R.; Erdmann B.; Lindschau C.; Haase H.; Morano I.; Luft F.C.; Wobus A.M.
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model
FASEB Journal 11 (11): 905-915 (1997-09)



Pichler M.; Cassidy T.N.; Reimer D.; Haase H.; Krause R.; Ostler D.; Striessnig J.
Beta subunit heterogeneity in neuronal L-type Ca2+ channels
Journal of Biological Chemistry 272 (21): 13877-13882 (1997-05-23)



Morano I.; Haedicke K.; Haase H.; Boehm M.; Erdmann E.; Schaub M.C.
Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart
Journal of Molecular and Cellular Cardiology 29 (4): 1177-1187 (1997-04)



Svensson C.; Morano I.; Arner A.
In vitro motility assay of atrial and ventricular myosin from pig
Journal of Cellular Biochemistry 67: 241-247 (1997-01-01)



Safayhi H.; Haase H.; Kramer U.; Bihlmayer A.; Roenfeldt M.; Ammon H.P.T.; Froschmayr M.; Cassidy T.N.; Morano I.; Ahlijanian M.K.; Striessnig J.
L- type calcium channels in insulin-secreting cells: biochemical characterization and phosphorylation in RINm5F cells
Molecular Endocrinology 11: 619-629 (1997-01-01)



McEnery M.W.; Haase H.; Vance C.L.; Dubel S.J.; Morano I.; Copeland T.D.; Choi Y.
beta1B subunit of voltage-dependent Ca2+ channels is predominant isoform expressed in human neuroblastoma cell line IMR32
FEBS Letters 420: 74-78 (1997-01-01)



Morano I.; Koehlen S.; Haase H.; Erb G.; Baltas L.G.; Rimbach S.; Wallwiener D.; Bastert G.
Alternative splicing and cycling kinetics of myosin change during hypertrophy of human smooth muscle cells
Journal of Cellular Biochemistry 64: 171-181 (1997-01-01)



Siegman M.J.; Butler T.M.; Mooers S.U.; Trinklemulcahy L.; Narayan S.; Adam L.; Chacko S.; Haase H.; Morano I.
Hypertrophy of colonic smooth muscle: contractile proteins, shortening velocity, and regulation
American Journal of Physiology Gastrointestinal and Liver Physiology 272: G1571-G1580 (1997-01-01)



McConnell B.K.; Schomisch-Moravec C.; Morano I.; Bond M.
Troponin I phosphorylation in cardiac myocytes from the spontaneously hypertensive rat: effect of beta-adrenergic stimulation
American Journal of Physiology Heart and Circulatory Physiology 273: H1440-H1451 (1997-01-01)



Morano I.; Haase H.
Different actin affinities of human cardiac essential myosin light chain isoforms
FEBS Letters 408: 71-74 (1997-01-01)



Luther H.P.; Morwinski R.; Wallukat G.; Haase H.; Morano I.
Expression of sense and naturally occurring antisense mrna of myosin heavy chain in rat heart tissue and cultivated cardiomyocytes
Journal of Molecular and Cellular Cardiology 29: 27-35 (1997-01-01)



Luther H.P.; Hille S.; Haase H.; Morano I.
Influence of mechanical activity, adrenergic stimulation, and calcium on the expression of myosin heavy chains in cultivated neonatal cardiomyocytes
Journal of Cellular Biochemistry 64: 458-465 (1997-01-01)



1996

Morano M.; Zacharzowski U.; Maier M.; Lange P.E.; Alexi-Meskishvili V.; Haase H.; Morano I.
Regulation of human heart contractility by essential myosin light chain isoforms
Journal of Clinical Investigation 98 (2): 467-473 (1996-07-15)



Sjuve R.; Haase H.; Morano I.; Uvelius B.; Arner A.
Contraction kinetics and myosin isoform composition in smooth muscle from hypertrophied rat urinary bladder
Journal of Cellular Biochemistry 63: 86-93 (1996-01-01)



Morano I.
Molecular regulation of smooth muscle contraction
Molecular Reviews in Cardiovascular Medicine : 49-53 (1996-01-01)



Haase H.; Bartel S.; Karczewski P.; Morano I.; Krause E.G.
In-vivo phosphorylation of the cardiac L-type calcium channel beta-subunit in response to catecholamines
Molecular and Cellular Biochemistry 163-164: 99-106 (1996-01-01)



Haase H.; Kresse A.; Hohaus A.; Schulte H.; Maier M.; Osterziel K.J.; Lange P.; Morano I.
Expression of calcium channel subunits in the normal and diseased human myocardium
Journal of Molecular Medicine 74: 99-104 (1996-01-01)



Haase H.; Morano I.
Alternative splicing of smooth muscle myosin heavy chains and its functional consequences
Journal of Cellular Biochemistry 60: 521-528 (1996-01-01)



1995

Morano I.; Ritter O.; Bonz A.; Timek T.; Vahl C.F.; Michel G.
Myosin light chain-actin interaction regulates cardiac contractility
Circulation Research 76 (5): 720-725 (1995-05)



Bartel S.; Karczewski P.; Morano I.; Krause E.G.
Function of C-protein and troponin I phosphorylation in the heart
Annals of the New York Academy of Sciences 752: 243-245 (1995-03-27)



Calovini T.; Haase H.; Morano I.
Steroid-hormone regulation of myosin subunit expression in smooth and cardiac muscle
Journal of Cellular Biochemistry 59: 69-78 (1995-01-01)



Morano I.; Oesterman A.; Arner A.
Rate of active tension development from rigor in skinned atrial and ventricular cardiac fibres from swine following photolytic release of ATP from caged ATP
Acta Physiologica Scandinavica 154 (3): 343-353 (1995-01-01)



Bartel S.; Willenbrock R.; Haase H.; Karczewski P.; Wallukat G.; Dietz R.; Krause E.G.
Cyclic GMP-mediated phospholamban phosphorylation in intact cardiomyocytes
Biochemical and Biophysical Research Communications 214 (1): 75-80 (1995-01-01)



Morano I.
Muskelphysiologie
Handbuch Sporttraumatologie Sportorthopaedie. Funktionelle Anatomie, Diagnostik, Therapie : 15-41 (1995-01-01)



1994

Goetz R.M.; Morano I.; Calovini T.; Studer R.; Holtz J.
Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy
Biochemical and Biophysical Research Communications 205 (1): 905-910 (1994-11-30)



Schwinger R.H.G.; Boehm M.; Koch A.; Schmidt U.; Morano I.; Eissner H.J.; Ueberfuhr P.; Reichart B.; Erdmann E.
The failing human heart is unable to use the frank- starling mechanism
Circulation Research 74 (5): 959-969 (1994-05-01)



Morano I.; Haedicke K.; Grom S.; Koch A.; Schwinger R.H.G.; Boehm M.; Bartel S.; Erdmann E.; Krause E.G.
Titin, myosin light chains, and c-protein in the developing and failing human heart
Journal of Molecular and Cellular Cardiology 26 (3): 361-368 (1994-03-01)



Bartel S.; Morano I.; Hunger H.D.; Katus H.; Pask H.; Karczewski P.; Krause E.G.
Cardiac troponin I and tension generation of skinned fibres in the developing rat heart
Journal of Molecular and Cellular Cardiology 26: 1123-1131 (1994-01-01)



Haase H.; Wallukat G.; Flockerzi V.; Nastainczyk W.; Hofmann F.
Detection of skeletal muscle calcium channel subunits in cultured neonatal rat cardiac myocytes
Receptors & Channels 2: 41-52 (1994-01-01)



Schwinger R.H.G.; Boehm M.; Koch A.; Morano I.; Rueegg J.C.; Erdmann E.
Inotropic effect of the cardioprotective agent 2,3- butanedione monoxime in failing and nonfailing human myocardium
Journal of Pharmacology and Experimental Therapeutics 269: 778-786 (1994-01-01)



1993

Haase H.; Karczewski P.; Beckert R.; Krause E.G.
Phosphorylation of the L-type calcium channel beta subunit is involved in beta-adrenergic signal transduction in canine myocardium
FEBS Letters 335 (2): 217-222 (1993-12-06)



Morano I.; Erb G.; Sogl B.
Expression of myosin heavy and light chains changes during pregnancy in the rat uterus
Pfluegers Archiv European Journal of Physiology 423: 434-441 (1993-01-01)



Morano I.
Myosin light chain phosphorylation and myosin isoenzyme expression regulate cardiac calcium sensitivity by modulation of cross-bridge cyclic kinetics
Modulation of cardiac calcium sensitivity. A new approach to increasing the strenght of the heart : 178-197 (1993-01-01)



Morano I.; Adler K.; Weismann K.; Knorr A.; Erdmann E.; Boehm M.
Correlation of myosin heavy chain expression in the rat with cAMP in different models of hypertension-induced cardiac hypertrophy
Journal of Molecular and Cellular Cardiology 25: 387-394 (1993-01-01)



Kaling M.; Morano I.
Androgene regulieren die Transkriptionsrate der schweren alpha -Myosinkette im Herzen
Zellulaere Mechanismen der Herz-Kreislaufregulation. Pharmakologische und klinische Konsequenzen : 151-158 (1993-01-01)



1992

Morano I.L.
Molecular biology of smooth muscle
Journal of Hypertension 10: 411-416 (1992-05-01)



Wiesner R.J.; Ruegg J.C.; Morano I.
Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues
Biochemical and Biophysical Research Communications 183 (2): 553-559 (1992-03-16)



Morano I.; Adler K.; Agostini B.; Hasselbach W.
Expression of myosin heavy and light chains and phosphorylation of the phosphorylatable myosin light chain in the heart ventricle of the European hamster during hibernation and in summer
Journal of Muscle Research and Cell Motility 13: 64-70 (1992-02-01)



1991

Adler K.; Boels P.; Ganten U.; Ganten D.; Morano I.
The influence of cold stress on the myosin heavy chain expression of cardiac and smooth muscle in normotensive and spontaneously hypertensive female rats
Circulation Research 69 (6): 1640-1644 (1991-12)



Gillardon F.; Morano I.; Ganten U.; Zimmermann M.
Regulation of calcitonin gene-related peptide mRNA expression in the hearts of spontaneously hypertensive rats by testosterone
Neuroscience Letters 125: 77-80 (1991-01-01)