Molecular Cardiovascular Research

embryo-2

Head of the Group

Prof. Dr. Thomas Willnow

Contact


Secretariat

Verona Kuhle

27: Walter-Friedrich House

Room 114

Tel. 9406-2387

Fax. 9406-3382

Contact


Receptor-mediated endocytosis is the main mechanism whereby cells take up essential metabolites and signaling molecules. Consequently, dysfunctions of endocytic receptors are the cause of many devastating diseases in humans.

Our group focuses on the functional characterization of endocytic receptors specifically expressed in neurons, elucidating the significance of these receptor pathways for embryonic development, for functional integrity, and for degenerative diseases of the central nervous system.

Mainly using transgenic cell and mouse models, we currently study the involvement of endocytic receptor pathways in two main projects.  In the first project, we characterize the role of endocytic receptors in developmental defects of the forebrain, an anomaly affecting as many as 1 in 250 human pregnancies. In the second major project, we explore endocytic pathways in neurons that are the underlying cause Alzheimer’s disease, a neurodegenerative disease that impacts millions of patients worldwide.

 

More detailed information about these projects can be found under “Research”

Some of our recent publications are listed here “Selected publications”

Here you get to know the people that do this work under “Team”


AFI BIH DFG ERC HGF Thyssen