Selected Publications


Park T.J.; Reznick J.; Peterson B.L.; Blass G.; Omerbasic D.; Bennett N.C.; Kuich P.H.J.L.; Zasada C.; Browe B.M.; Hamann W.; Applegate D.T.; Radke M.H.; Kosten T.; Lutermann H.; Gavaghan V.; Eigenbrod O.; Begay V.; Amoroso V. G.; Govind V.; Minshall R.D.; Smith E.S.J.; Larson J.; Gotthardt M.; Kempa S.; Lewin G.R.
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Science 356 (6335): 307-311 (2017-04-21)


Brandenburg S.; Kohl T.; Williams G.S.B.; Gusev K.; Wagner E.; Rog-Zielinska E.A.; Hebisch E.; Dura M.; Didie M.; Gotthardt M.; Nikolaev V.O.; Hasenfuss G.; Kohl P.; Ward C.W.; Lederer W.J.; Lehnart S.E.
Axial tubule junctions control rapid calcium signaling in atria
Journal of Clinical Investigation 126 (10): 3999-4015 (2016-10-03)


Roberts A.M.; Ware J.S.; Herman D.S.; Schafer S.; Baksi J.; Bick A.G.; Buchan R.J.; Walsh R.; John S.; Wilkinson S.; Mazzarotto F.; Felkin L.E.; Gong S.; MacArthur J.A.L.; Cunningham F.; Flannick J.; Gabriel S.B.; Altshuler D.M.; Macdonald P.S.; Heinig M.; Keogh A.M.; Hayward C.S.; Banner N.R.; Pennell D.J.; O'Regan D.P.; San T.R.; de Marvao A.; Dawes T.J.W.; Gulati A.; Birks E.J.; Yacoub M.H.; Radke M.; Gotthardt M.; Wilson J.G.; O'Donnell C.J.; Prasad S.K.; Barton P.J.R.; Fatkin D.; Hubner N.; Seidman J.G.; Seidman C.E.; Cook S.A.
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
Science Translational Medicine 7 (270): 270ra6 (2015-01-14)


Maatz H.; Jens M.; Liss M.; Schafer S.; Heinig M.; Kirchner M.; Adami E.; Rintisch C.; Dauksaite V.; Radke M.H.; Selbach M.; Barton P.J.R.; Cook S.A.; Rajewsky N.; Gotthardt M.; Landthaler M.; Hubner N.
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing
Journal of Clinical Investigation 124 (8): 3419-3430 (2014-08-01)

Marsman R.F.J.; Bezzina C.R.; Freiberg F.; Verkerk A.O.; Adriaens M.E.; Podliesna S.; Chen C.; Purfuerst B.; Spallek B.; Koopmann T.T.; Baczko I.; Dos Remedios C.G.; George A.L.; Bishopric N.H.; Lodder E.M.; de Bakker J.M.T.; Fischer R.; Coronel R.; Wilde A.A.M.; Gotthardt M.; Remme C.A.
Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia
Journal of the American College of Cardiology 63 (6): 549-559 (2014-02-18)


Schreier B.; Rabe S.; Schneider B.; Bretschneider M.; Rupp S.; Ruhs S.; Neumann J.; Rueckschloss U.; Sibilia M.; Gotthardt M.; Grossmann C.; Gekle M.
Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy
Hypertension 61 (2): 333-340 (2013-02)


Guo W.; Schafer S.; Greaser M.L.; Radke M.H.; Liss M.; Govindarajan T.; Maatz H.; Schulz H.; Lincoln S.E.; Parrish A.M.; Dauksaite V.; Vakeel P.; Klaassen S.; Gerull B.; Thierfelder L.; Regitz-Zagrosek V.; Hacker T.A.; Saupe K.W.; Dec G.W.; Ellinor P.T.; MacRae C.A.; Spallek B.; Fischer R.; Perrot A.; Ozcelik C.; Saar K.; Hubner N.; Gotthardt M.
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Nature Medicine 18 (5): 766-773 (2012-05)


da Silva Lopes K.; Pietas A.; Radke M.H.; Gotthardt M.
Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres
Journal of Cell Biology 193 (4): 785-798 (2011-05-16)


Granzier H.L.; Radke M.H.; Peng J.; Westermann D.; Nelson O.L.; Rost K.; King N.M.; Yu Q.; Tschoepe C.; McNabb M.; Larson D.F.; Labeit S.; Gotthardt M.
Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction
Circulation Research 105 (6): 557-564 (2009-09-11)

Shi Y.; Chen C.; Lisewski U.; Wrackmeyer U.; Radke M.; Westermann D.; Sauter M.; Tschoepe C.; Poller W.; Klingel K.; Gotthardt M.
Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo
Journal of the American College of Cardiology 53 (14): 1219-1226 (2009-04-07)


Lisewski U.; Shi Y.; Wrackmeyer U.; Fischer R.; Chen C.; Schirdewan A.; Juettner R.; Rathjen F.G.; Poller W.; Radke M.H.; Gotthardt M.
The tight junction protein CAR regulates cardiac conduction and cell-cell communication
Journal of Experimental Medicine 205 (10): 2369-2379 (2008-09-29)


Jansen P.; Giehl K.; Nyengaard J.R.; Teng K.; Lioubinski O.; Sjoegaard S.S.; Breiderhoff T.; Gotthardt M.; Lin F.; Eilers A.; Petersen C.M.; Lewin G.R.; Hempstead B.L.; Willnow T.E.; Nykjaer A.
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Nature Neuroscience 10 (11): 1449-1457 (2007-11)

Radke M.H.; Peng J.; Wu Y.; McNabb M.; Nelson O.L.; Granzier H.; Gotthardt M.
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy
Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3444-3449 (2007-02-27)

Peng J.; Raddatz K.; Molkentin J.D.; Wu Y.; Labeit S.; Granzier H.; Gotthardt M.
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region
Circulation 115 (6): 743-751 (2007-02-13)


Weinert S.; Bergmann N.; Luo X.; Erdmann B.; Gotthardt M.
M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere
Journal of Cell Biology 173 (4): 559-570 (2006-05-22)


Andersen O.M.; Reiche J.; Schmidt V.; Gotthardt M.; Spoelgen R.; Behlke J.; von Arnim C.A.F.; Breiderhoff T.; Jansen P.; Wu X.; Bales K.R.; Cappai R.; Masters C.L.; Gliemann J.; Mufson E.J.; Hyman B.T.; Paul S.M.; Nykjaer A.; Willnow T.E.
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466 (2005-09-07)


Boucher P.; Gotthardt M.; Li W.P.; Anderson R.G.; Herz J.
LRP: role in vascular wall integrity and protection from atherosclerosis
Science 300: 329-332 (2003-04-11)


Holtwick R.; Gotthardt M.; Skryabin B.; Steinmetz M.; Potthast R.; Zetsche B.; Hammer R.E.; Herz J.; Kuhn M.
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure
Proceedings of the National Academy of Sciences of the United States of America 99: 7142-7147 (2002-05-14)


Bang M.L.; Centner T.; Fornoff F.; Geach A.J.; Gotthardt M.; McNabb M.; Witt C.C.; Labeit D.; Gregorio C.C.; Granzier H.; Labeit S.
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system
Circulation Research 89: 1065-1072 (2001-11-23)


Stockinger W.; Brandes C.; Fasching D.; Hermann M.; Gotthardt M.; Herz J.; Schneider W.J.; Nimpf J.
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
Journal of Biological Chemistry 275 (33): 25625-25632 (2000-08-18)

Gotthardt M.; Trommsdorff M.; Nevitt M.F.; Shelton J.; Richardson J.A.; Stockinger W.; Nimpf J.; Herz J.
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
Journal of Biological Chemistry 275 (33): 25616-25624 (2000-08-18)

Schmitz C.; Gotthardt M.; Hinderlich S.; Leheste J.R.; Gross V.; Vorum H.; Christensen E.I.; Luft F.C.; Takahashi S.; Willnow T.E.
Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor
Journal of Biological Chemistry 275 (20): 15357-15362 (2000-05-19)


Trommsdorff M.; Gotthardt M.; Hiesberger T.; Shelton J.; Stockinger W.; Nimpf J.; Hammer R.E.; Richardson J.A.; Herz J.
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
Cell 97 (6): 689-701 (1999-06-11)


Rohlmann A.; Gotthardt M.; Hammer R.E.; Herz J.
Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
Journal of Clinical Investigation 101 (3): 689-695 (1998-02-01)