Publications



2017

Oberheide K.; Puchkov D.; Jentsch T.J.
Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation
Journal of Biological Chemistry : (2017-05-05)



Lutter D.; Ullrich F.; Lueck J.C.; Kempa S.; Jentsch T.J.
Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels
Journal of Cell Science 130 (6): 1122-1133 (2017-03-15)



Hennings J.C.; Andrini O.; Picard N.; Paulais M.; Huebner A.K.; Cayuqueo I.K.L.; Bignon Y.; Keck M.; Corniere N.; Boehm D.; Jentsch T.J.; Chambrey R.; Teulon J.; Huebner C.A.; Eladari D.
The ClC-K2 chloride channel is critical for salt handling in the distal nephron
Journal of the American Society of Nephrology 28 (1): 209-217 (2017-01)



2016

Palmer E.E.; Stuhlmann T.; Weinert S.; Haan E.; Van Esch H.; Holvoet M.; Boyle J.; Leffler M.; Raynaud M.; Moraine C.; van Bokhoven H.; Kleefstra T.; Kahrizi K.; Najmabadi H.; Ropers H.H.; Delgado M.R.; Sirsi D.; Golla S.; Sommer A.; Pietryga M.P.; Chung W.K.; Wynn J.; Rohena L.; Bernardo E.; Hamlin D.; Faux B.M.; Grange D.K.; Manwaring L.; Tolmie J.; Joss S.; Cobben J.M.; Duijkers F.A.M.; Goehringer J.M.; Challman T.D.; Hennig F.; Fischer U.; Grimme A.; Suckow V.; Musante L.; Nicholl J.; Shaw M.; Lodh S.P.; Niu Z.; Rosenfeld J.A.; Stankiewicz P.; Jentsch T.J.; Gecz J.; Field M.; Kalscheuer V.M.
De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females
Molecular Psychiatry : (2016-08-23)



Ullrich F.; Reincke S.M.; Voss F.K.; Stauber T.; Jentsch T.J.
Inactivation and anion selectivity of volume-regulated VRAC channels depend on carboxy-terminal residues of the first extracellular loop
Journal of Biological Chemistry 291 (33): 17040-17048 (2016-08-12)



Goedde K.; Gschwend O.; Puchkov D.; Pfeffer C.K.; Carleton A.; Jentsch T.J.
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
Nature Communications 7: 12043 (2016-07-08)



Jentsch T.J.
VRACs and other ion channels and transporters in the regulation of cell volume and beyond
Nature Reviews Molecular Cell Biology 17 (5): 293-307 (2016-05)



Schuetze S.; Orozco I.J.; Jentsch T.J.
KCNQ potassium channels modulate sensitivity of skin D-hair mechanoreceptors
Journal of Biological Chemistry 291 (11): 5566-5575 (2016-03-11)



Jentsch T.J.; Lutter D.; Planells-Cases R.; Ullrich F.; Voss F.K.
VRAC: molecular identification as LRRC8 heteromers with differential functions
Pflugers Archiv 468 (3): 385-393 (2016-03)



Hu H.; Haas S.A.; Chelly J.; Van Esch H.; Raynaud M.; de Brouwer A.P.M.; Weinert S.; Froyen G.; Frints S.G.M.; Laumonnier F.; Zemojtel T.; Love M.I.; Richard H.; Emde A.K.; Bienek M.; Jensen C.; Hambrock M.; Fischer U.; Langnick C.; Feldkamp M.; Wissink-Lindhout W.; Lebrun N.; Castelnau L.; Rucci J.; Montjean R.; Dorseuil O.; Billuart P.; Stuhlmann T.; Shaw M.; Corbett M.A.; Gardner A.; Willis-Owen S.; Tan C.; Friend K.L.; Belet S.; van Roozendaal K.E.P.; Jimenez-Pocquet M.; Moizard M.P.; Ronce N.; Sun R.; O'Keeffe S.; Chenna R.; van Boemmel A.; Goeke J.; Hackett A.; Field M.; Christie L.; Boyle J.; Haan E.; Nelson J.; Turner G.; Baynam G.; Gillessen-Kaesbach G.; Mueller U.; Steinberger D.; Budny B.; Badura-Stronka M.; Latos-Bielenika A.; Ousager L.B.; Wieacker P.; Rodriguez Criado G.; Bondeson M.L.; Anneren G.; Dufke A.; Cohen M.; Van Maldergem L.; Vincent-Delorme C.; Echenne B.; Simon-Bouy B.; Kleefstra T.; Willemsen M.; Fryns J.P.; Devriendt K.; Ullmann R.; Vingron M.; Wrogemann K.; Wienker T.F.; Tzschach A.; van Bokhoven H.; Gecz J.; Jentsch T.J.; Chen W.; Ropers H.H.; Kalscheuer V.M.
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes
Molecular Psychiatry 21 (1): 133-148 (2016-01)



2015

Rost B.R.; Schneider F.; Grauel M.K.; Wozny C.; Bentz C.G.; Blessing A.; Rosenmund T.; Jentsch T.J.; Schmitz D.; Hegemann P.; Rosenmund C.
Optogenetic acidification of synaptic vesicles and lysosomes
Nature Neuroscience 18 (12): 1845-1852 (2015-12)



Planells-Cases R.; Lutter D.; Guyader C.; Gerhards N.M.; Ullrich F.; Elger D.A.; Kucukosmanoglu A.; Xu G.; Voss F.K.; Reincke S.M.; Stauber T.; Blomen V.A.; Vis D.J.; Wessels L.F.; Brummelkamp T.R.; Borst P.; Rottenberg S.; Jentsch T.J.
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs
EMBO Journal 34 (24): 2993-3008 (2015-12)



Jentsch T.J.
Discovery of CLC transport proteins: cloning, structure, function and pathophysiology
Journal of Physiology 593 (18): 4091-4109 (2015-09-15)



Varga R.E.; Khundadze M.; Damme M.; Nietzsche S.; Hoffmann B.; Stauber T.; Koch N.; Hennings J.C.; Franzka P.; Huebner A.K.; Kessels M.M.; Biskup C.; Jentsch T.J.; Qualmann B.; Braulke T.; Kurth I.; Beetz C.; Huebner C.A.
In vivo evidence for lysosome depletion and impaired autophagic clearance in hereditary spastic paraplegia type SPG11
PLoS Genetics 11 (8): e1005454 (2015-08-18)



Jentsch T.J.; Hoegg-Beiler M.B.; Vogt J.
Departure gate of acidic Ca2+ confirmed
EMBO Journal 34 (13): 1737-1739 (2015-07-02)



Fidzinski P.; Korotkova T.; Heidenreich M.; Maier N.; Schuetze S.; Kobler O.; Zuschratter W.; Schmitz D.; Ponomarenko A.; Jentsch T.J.
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations
Nature Communications 6: 6254 (2015-02-04)



2014

Schleifenbaum J.; Kassmann M.; Szijarto I.A.; Hercule H.C.; Tano J.Y.; Weinert S.; Heidenreich M.; Pathan A.R.; Anistan Y.M.; Alenina N.; Rusch N.J.; Bader M.; Jentsch T.J.; Gollasch M.
Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries
Circulation Research 115 (2): 263-272 (2014-07-07)



Weinert S.; Jabs S.; Hohensee S.; Chan W.L.; Kornak U.; Jentsch T.J.
Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions
EMBO Reports 15 (7): 784-791 (2014-07-01)



Voss F.K.; Ullrich F.; Muench J.; Lazarow K.; Lutter D.; Mah N.; Andrade-Navarro M.A.; von Kries J.P.; Stauber T.; Jentsch T.J.
Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC
Science 344 (6184): 634-638 (2014-05-09)



Barvencik F.; Kurth I.; Koehne T.; Stauber T.; Zustin J.; Tsiakas K.; Ludwig C.F.; Beil F.T.; Pestka J.M.; Hahn M.; Santer R.; Supanchart C.; Kornak U.; Del Fattore A.; Jentsch T.; Teti A.; Schulz A.; Schinke T.; Amling M.
CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals
Journal of Bone and Mineral Research 29 (4): 982-991 (2014-04)



Hoegg-Beiler M.B.; Sirisi S.; Orozco I.J.; Ferrer I.; Hohensee S.; Auberson M.; Goedde K.; Vilches C.; de Heredia M.L.; Nunes V.; Estevez R.; Jentsch T.J.
Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction
Nature Communications 5: 3475 (2014-03-19)



Sartelet A.; Stauber T.; Coppieters W.; Ludwig C.F.; Fasquelle C.; Druet T.; Zhang Z.; Ahariz N.; Cambisano N.; Jentsch T.J.; Charlier C.
A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle
Disease Models & Mechanisms 7 (1): 119-128 (2014-01)



Supanchart C.; Wartosch L.; Schlack C.; Kuehnisch J.; Giehl M.; Felsenberg D.; Fuhrmann J.C.; de Vernejoul M.C.; Jentsch T.J.; Kornak U.
ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion
Bone 58: 92-102 (2014-01)



2013

Ludwig C.F.; Ullrich F.; Leisle L.; Stauber T.; Jentsch T.J.
Common gating of both CLC subunits underlies voltage-dependent activation of the 2Cl-/1H+-exchanger ClC-7/Ostm1
Journal of Biological Chemistry 288 (40): 28611-28619 (2013-10-04)



Jentsch T.J.
From mice to man: chloride transport in leukoencephalopathy
Lancet Neurology 12 (7): 626-628 (2013-07)



Veeramah K.R.; Johnstone L.; Karafet T.M.; Wolf D.; Sprissler R.; Salogiannis J.; Barth-Maron A.; Greenberg M.E.; Stuhlmann T.; Weinert S.; Jentsch T.J.; Pazzi M.; Restifo L.L.; Talwar D.; Erickson R.P.; Hammer M.F.
Exome sequencing reveals new causal mutations in children with epileptic encephalopathies
Epilepsia 54 (7): 1270-1281 (2013-07)



Spitzmaul G.; Tolosa L.; Winkelman B.H.J.; Heidenreich M.; Frens M.A.; Chabbert C.; de Zeeuw C.I.; Jentsch T.J.
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models
Journal of Biological Chemistry 288 (13): 9334-9344 (2013-03-29)



Stauber T.; Jentsch T.J.
Chloride in vesicular trafficking and function
Annual Review of Physiology 75: 453-477 (2013-02-10)



2012

Hennings J.C.; Picard N.; Huebner A.K.; Stauber T.; Maier H.; Brown D.; Jentsch T.J.; Vargas-Poussou R.; Eladari D.; Huebner C.A.
A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule
EMBO Molecular Medicine 4 (10): 1057-1071 (2012-10)



Stauber T.; Weinert S.; Jentsch T.J.
Cell biology and physiology of CLC chloride channels and transporters
Comprehensive Physiology 2 (3): 1701-1744 (2012-07-01)



Jeworutzki E.; Lopez-Hernandez T.; Capdevila-Nortes X.; Sirisi S.; Bengtsson L.; Montolio M.; Zifarelli G.; Arnedo T.; Mueller C.S.; Schulte U.; Nunes V.; Martinez A.; Jentsch T.J.; Gasull X.; Pusch M.; Estevez R.
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit
Neuron 73 (5): 951-961 (2012-03-08)



Seja P.; Schonewille M.; Spitzmaul G.; Badura A.; Klein I.; Rudhard Y.; Wisden W.; Huebner C.A.; De Zeeuw C.I.; Jentsch T.J.
Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning
EMBO Journal 31 (5): 1217-1230 (2012-01-17)



Heidenreich M.; Lechner S.G.; Vardanyan V.; Wetzel C.; Cremers C.W.; De Leenheer E.M.; Aranguez G.; Moreno-Pelayo M.A.; Jentsch T.J.; Lewin G.R.
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man
Nature Neuroscience 15 (1): 138-145 (2012)



2011

Khalilov I.; Chazal G.; Chudotvorova I.; Pellegrino C.; Corby S.; Ferrand N.; Gubkina O.; Nardou R.; Tyzio R.; Yamamoto S.; Jentsch T.J.; Huebner C.A.; Gaiarsa J.L.; Ben-Ari Y.; Medina I.
Enhanced synaptic activity and epileptiform events in the embryonic KCC2 deficient hippocampus
Frontiers in Cellular Neuroscience 5: 23 (2011-11-01)



Nomura N.; Tajima M.; Sugawara N.; Morimoto T.; Kondo Y.; Ohno M.; Uchida K.; Mutig K.; Bachmann S.; Soleimani M.; Ohta E.; Ohta A.; Sohara E.; Okado T.; Rai T.; Jentsch T.J.; Sasaki S.; Uchida S.
Generation and analyses of R8L barttin knockin mouse
American Journal of Physiology Renal Physiology 301 (2): F297-F307 (2011-08)



Leisle L.; Ludwig C.F.; Wagner F.A.; Jentsch T.J.; Stauber T.
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity
EMBO Journal 30 (11): 2140-2152 (2011-06-01)



Billig G.M.; Pal B.; Fidzinski P.; Jentsch T.J.
Ca(2+)-activated Cl(-) currents are dispensable for olfaction
Nature Neuroscience 14 (6): 763-769 (2011-06)



2010

Pressey S.N.; O'Donnell K.J.; Stauber T.; Fuhrmann J.C.; Tyynelae J.; Jentsch T.J.; Cooper J.D.
Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1
Journal of Neuropathology and Experimental Neurology 69 (12): 1228-1246 (2010-12)



Stauber T.; Jentsch T.J.
Sorting motifs of the endosomal/lysosomal CLC chloride transporters
Journal of Biological Chemistry 285 (45): 34537-34548 (2010-11-05)



Jentsch T.J.; Maritzen T.; Keating D.J.; Zdebik A.A.; Thevenod F.
ClC-3-A granular anion transporter involved in insulin secretion?
Cell Metabolism 12 (4): 307-308 (2010-10-06)



Neagoe I.; Stauber T.; Fidzinski P.; Bergsdorf E.Y.; Jentsch T.J.
The late endosomal CLC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression
Journal of Biological Chemistry 285 (28): 21689-21697 (2010-07-09)



Steinberg B.E.; Huynh K.K.; Brodovitch A.; Jabs S.; Stauber T.; Jentsch T.J.; Grinstein S.
A cation counterflux supports lysosomal acidification
Journal of Cell Biology 189 (7): 1171-1186 (2010-06-28)



Weinert S.; Jabs S.; Supanchart C.; Schweizer M.; Gimber N.; Richter M.; Rademann J.; Stauber T.; Kornak U.; Jentsch T.J.
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation
Science 328 (5984): 1401-1403 (2010-06-11)



Novarino G.; Weinert S.; Rickheit G.; Jentsch T.J.
Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis
Science 328 (5984): 1398-1401 (2010-06-11)



Rickheit G.; Wartosch L.; Schaffer S.; Stobrawa S.; Novarino G.; Weinert S.; Jentsch T.J.
Role of CLC-5 in renal endocytosis is unique among CLC exchangers and does not require py-motif-dependent ubiquitylation
Journal of Biological Chemistry 285 (23): 17595-17603 (2010-06-04)



Tzingounis A.V.; Heidenreich M.; Kharkovets T.; Spitzmaul G.; Jensen H.S.; Nicoll R.A.; Jentsch T.J.
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus
Proceedings of the National Academy of Sciences of the United States of America 107 (22): 10232-10237 (2010-06-01)



Scheper G.C.; van Berkel C.G.; Leisle L.; de Groot K.E.; Errami A.; Jentsch T.J.; Van der Knaap M.S.
Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts
Genetic Testing and Molecular Biomarkers 14 (2): 255-257 (2010-04)



Preston P.; Wartosch L.; Guenzel D.; Fromm M.; Kongsuphol P.; Ousingsawat J.; Kunzelmann K.; Barhanin J.; Warth R.; Jentsch T.J.
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport
Journal of Biological Chemistry 285 (10): 7165-7175 (2010-03-05)



Stauber T.; Novarino G.; Jentsch T.J.
The CLC family of chloride channels and transporters
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System : From Molecules to Diseases : 209-231 (2010)



2009

Wartosch L.; Fuhrmann J.C.; Schweizer M.; Stauber T.; Jentsch T.J.
Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7
FASEB Journal 23 (12): 4056-4068 (2009-12)



Zdebik A.A.; Wangemann P.; Jentsch T.J.
Potassium ion movement in the inner ear: insights from genetic disease and mouse models
Physiology 24 (5): 307-316 (2009-10)



Plans V.; Rickheit G.; Jentsch T.J.
Physiological roles of CLC Cl(-)/H (+) exchangers in renal proximal tubules
Pfluegers Archiv European Journal of Physiology 458 (1): 23-37 (2009-05)



Bergsdorf E.Y.; Zdebik A.A.; Jentsch T.J.
Residues important for nitrate/proton coupling in plant and mammalian CLC transporters
Journal of Biological Chemistry 284 (17): 11184-11193 (2009-04-24)



Pfeffer C.K.; Stein V.; Keating D.J.; Maier H.; Rinke I.; Rudhard Y.; Hentschke M.; Rune G.M.; Jentsch T.J.; Huebner C.A.
NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development
Journal of Neuroscience 29 (11): 3419-3430 (2009-03-18)



Planells-Cases R.; Jentsch T.J.
Chloride channelopathies
Biochimica et Biophysica Acta - Molecular Basis of Disease 1792 (3): 173-189 (2009-03)



2008

Rickheit G.; Maier H.; Strenzke N.; Andreescu C.E.; De Zeeuw C.I.; Muenscher A.; Zdebik A.A.; Jentsch T.J.
Endocochlear potential depends on Cl(-) channels: mechanism underlying deafness in Bartter syndrome IV
EMBO Journal 27 (21): 2907-2917 (2008-11-05)



Maritzen T.; Keating D.J.; Neagoe I.; Zdebik A.A.; Jentsch T.J.
Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue
Journal of Neuroscience 28 (42): 10587-10598 (2008-10-15)



Zdebik A.A.; Zifarelli G.; Bergsdorf E.Y.; Soliani P.; Scheel O.; Jentsch T.J.; Pusch M.
Determinants of anion-proton coupling in mammalian endosomal CLC proteins
Journal of Biological Chemistry 283 (7): 4219-4227 (2008-02-15)



Jentsch T.J.
CLC chloride channels and transporters: from genes to protein structure, pathology and physiology
Critical Reviews in Biochemistry and Molecular Biology 43 (1): 3-36 (2008-01)



2007

Blanz J.; Schweizer M.; Auberson M.; Maier H.; Muenscher A.; Huebner C.A.; Jentsch T.J.
Leukoencephalopathy upon disruption of the chloride channel ClC-2
Journal of Neuroscience 27 (24): 6581-9 (2007-06-13)



Rust M.B.; Alper S.L.; Rudhard Y.; Shmukler B.E.; Vicente R.; Brugnara C.; Trudel M.; Jentsch T.J.; Huebner C.A.
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice
Journal of Clinical Investigation 117 (6): 1708-1717 (2007-06-01)



Jentsch T.J.
Chloride and the endosomal/lysosomal pathway: emerging roles of CLC chloride transporters
Journal of Physiology 578 (Pt 3): 633-640 (2007-02)



2006

Poet M.; Kornak U.; Schweizer M.; Zdebik A.A.; Scheel O.; Hoelter S.; Wurst W.; Schmitt A.; Fuhrmann J.C.; Planells-Cases R.; Mole S.E.; Huebner C.A.; Jentsch T.J.
Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6
Proceedings of the National Academy of Sciences of the United States of America 103 (37): 13854-13859 (2006-09-12)



Maritzen T.; Rickheit G.; Schmitt A.; Jentsch T.J.
Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice
Kidney International 70 (1): 79-87 (2006-07-01)



Schwake M.; Athanasiadu D.; Beimgraben C.; Blanz J.; Beck C.; Jentsch T.J.; Saftig P.; Friedrich T.
Structural determinants of M-type KCNQ (Kv7) K+ channel assembly
Journal of Neuroscience 26 (14): 3757-3766 (2006-04-05)



Lange P.F.; Wartosch L.; Jentsch T.J.; Fuhrmann J.C.
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function
Nature 440 (7081): 220-223 (2006-03-09)



Rust M.B.; Faulhaber J.; Budack M.K.; Pfeffer P.; Maritzen T.; Didie M.; Beck F.X.; Boettger T.; Schubert R.; Ehmke H.; Jentsch T.J.; Huebner C.A.
Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3
Circulation Research 98 (4): 549-556 (2006-03-03)



Kharkovets T.; Dedek K.; Maier H.; Schweizer M.; Khimich D.; Nouvian R.; Vardanyan V.; Leuwer R.; Moser T.; Jentsch T.J.
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness
EMBO Journal 25 (3): 642-652 (2006-02-08)



Hentschke M.; Wiemann M.; Hentschke S.; Kurth I.; Hermans-Borgmeyer I.; Seidenbecher T.; Jentsch T.J.; Gal A.; Huebner C.A.
Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold
Molecular and Cellular Biology 26 (1): 182-191 (2006-01)



2005

Jentsch T.J.; Maritzen T.; Zdebik A.A.
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function
Journal of Clinical Investigation 115 (8): 2039-2046 (2005-08)



Scheel O.; Zdebik A.A.; Lourdel S.; Jentsch T.J.
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins
Nature 436 (7049): 424-427 (2005-07-21)



Jentsch T.J.; Neagoe I.; Scheel O.
CLC chloride channels and transporters
Current Opinion in Neurobiology 15 (3): 319-325 (2005-06)



Schenzer A.; Friedrich T.; Pusch M.; Saftig P.; Jentsch T.J.; Groetzinger J.; Schwake M.
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine
Journal of Neuroscience 25 (20): 5051-5060 (2005-05-18)



Kasper D.; Planells-Cases R.; Fuhrmann J.C.; Scheel O.; Zeitz O.; Ruether K.; Schmitt A.; Poet M.; Steinfeld R.; Schweizer M.; Kornak U.; Jentsch T.J.
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration
EMBO Journal 24 (5): 1079-1091 (2005-03-09)



Jentsch T.J.; Poet M.; Fuhrmann J.C.; Zdebik A.A.
Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models
Annual Review of Physiology 67: 779-807 (2005-03)



Pusch M.; Jentsch T.J.
Unique structure and function of chloride transporting CLC proteins
IEEE Transactions on Nanobioscience 4 (1): 49-57 (2005-03)



2004

Jentsch T.J.; Huebner C.A.; Fuhrmann J.C.
Ion channels: function unravelled by dysfunction
Nature Cell Biology 6 (11): 1039-1047 (2004-11)



Huber S.M.; Duranton C.; Henke G.; Van De Sand C.; Heussler V.; Shumilina E.; Sandu C.D.; Tanneur V.; Brand V.; Kasinathan R.S.; Lang K.S.; Kremsner P.G.; Huebner C.A.; Rust M.B.; Dedek K.; Jentsch T.J.; Lang F.
Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte
Journal of Biological Chemistry 279 (40): 41444-41452 (2004-10-01)



Estevez R.; Pusch M.; Ferrer-Costa C.; Orozco M.; Jentsch T.J.
Functional and structural conservation of CBS domains from CLC chloride channels
Journal of Physiology 557 (Pt 2): 363-378 (2004-06-01)



Zdebik A.A.; Cuffe J.E.; Bertog M.; Korbmacher C.; Jentsch T.J.
Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models
Journal of Biological Chemistry 279 (21): 22276-22283 (2004-05-21)



Stein V.; Hermans-Borgmeyer I.; Jentsch T.J.; Huebner C.A.
Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride
Journal of Comparative Neurology 468 (1): 57-64 (2004-01-01)



2003

Boettger T.; Rust M.B.; Maier H.; Seidenbecher T.; Schweizer M.; Keating D.J.; Faulhaber J.; Ehmke H.; Pfeffer C.; Scheel O.; Lemcke B.; Horst J.; Leuwer R.; Pape H.C.; Voelkl H.; Huebner C.A.; Jentsch T.J.
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
EMBO Journal 22 (20): 5422-5434 (2003-10-15)



Estevez R.; Schroeder B.C.; Accardi A.; Jentsch T.J.; Pusch M.
Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1
Neuron 38 (1): 47-59 (2003-04-10)



Guenther W.; Piwon N.; Jentsch T.J.
The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease
Pfluegers Archiv European Journal of Physiology 445 (4): 456-462 (2003-01)



Schwake M.; Jentsch T.J.; Friedrich T.
A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly
EMBO Reports 4 (1): 76-81 (2003-01)



2002

Huebner C.A.; Jentsch T.J.
Ion channel diseases
Human Molecular Genetics 11 (20): 2435-2445 (2002-10-01)



Estevez R.; Jentsch T.J.
CLC chloride channels: correlating structure with function
Current Opinion in Structural Biology 12 (4): 531-539 (2002-08)



Boettger T.; Huebner C.A.; Maier H.; Rust M.B.; Beck F.X.; Jentsch T.J.
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4
Nature 416 (6883): 874-878 (2002-04-25)



Jentsch T.J.; Stein V.; Weinreich F.; Zdebik A.A.
Molecular structure and physiological function of chloride channels
Physiological Reviews 82 (2): 503-568 (2002-04)



Jentsch T.J.
Chloride channels are different
Nature 415 (6869): 276-277 (2002-01-17)



2001

Estevez R.; Boettger T.; Stein V.; Birkenhaeger R.; Otto E.; Hildebrandt F.; Jentsch T.J.
Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion
Nature 414 (6863): 558-561 (2001-11-29)



Dedek K.; Kunath B.; Kananura C.; Reuner U.; Jentsch T.J.; Steinlein O.K.
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel
Proceedings of the National Academy of Sciences of the United States of America 98 (21): 12272-12277 (2001-10-09)



Betz R.C.; Schoser B.G.H.; Kasper D.; Ricker K.; Ramirez A.; Stein V.; Torbergsen T.; Lee Y.A.; Nothen M.M.; Wienker T.F.; Malin J.P.; Propping P.; Reis A.; Mortier W.; Jentsch T.J.; Vorgerd M.; Kubisch C.
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease
Nature Genetics 28 (3): 218-219 (2001-07)



Schwake M.; Friedrich T.; Jentsch T.J.
An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease
Journal of Biological Chemistry 276 (15): 12049-12054 (2001-04-13)



Boesl M.R.; Stein V.; Huebner C.A.; Zdebik A.A.; Jordt S.E.; Mukhopadhyay A.K.; Davidoff M.S.; Holstein A.F.; Jentsch T.J.
Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption
EMBO Journal 20 (6): 1289-1299 (2001-03-15)



Huebner C.A.; Stein V.; Hermans-Borgmeyer I.; Meyer T.; Ballanyi K.; Jentsch T.J.
Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition
Neuron 30 (2): 515-524 (2001-03)



Vandewalle A.; Cluzeaud F.; Peng K.C.; Bens M.; Luechow A.; Guenther W.; Jentsch T.J.
Tissue distribution and subcellular localization of the ClC-5 chloride channel in rat intestinal cells
American Journal of Physiology Cell Physiology 280 (2): C373-C381 (2001-02)



Weinreich F.; Jentsch T.J.
Pores formed by single subunits in mixed dimers of different CLC chloride channels
Journal of Biological Chemistry 276 (4): 2347-2353 (2001-01-26)



Kornak U.; Kasper D.; Boesl M.R.; Kaiser E.; Schweizer M.; Schulz A.; Friedrich W.; Delling G.; Jentsch T.J.
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man
Cell 104 (2): 205-215 (2001-01-26)



Stobrawa S.M.; Breiderhoff T.; Takamori S.; Engel D.; Schweizer M.; Zdebik A.A.; Boesl M.R.; Ruether K.; Jahn H.; Draguhn A.; Jahn R.; Jentsch T.J.
Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus
Neuron 29 (1): 185-196 (2001-01)



2000

Piwon N.; Guenther W.; Schwake M.; Boesl M.R.; Jentsch T.J.
ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease
Nature 408 (6810): 369-373 (2000-11-16)



Jentsch T.J.
Neuronal KCNQ potassium channels: physiology and role in disease
Nature Reviews Neuroscience 1 (1): 21-30 (2000-10)



Kornak U.; Schulz A.; Friedrich W.; Uhlhaas S.; Kremens B.; Voit T.; Hasan C.; Bode U.; Jentsch T.J.; Kubisch C.
Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis
Human Molecular Genetics 9 (13): 2059-2063 (2000-08-12)



Waldegger S.; Jentsch T.J.
Functional and structural analysis of ClC-K chloride channels involved in renal disease
Journal of Biological Chemistry 275 (32): 24527-24533 (2000-08-11)



Schroeder B.C.; Hechenberger M.; Weinreich F.; Kubisch C.; Jentsch T.J.
KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
Journal of Biological Chemistry 275 (31): 24089-24095 (2000-08-04)



Yamamoto K.; Cox J.P.; Friedrich T.; Christie P.T.; Bald M.; Houtman P.N.; Lapsley M.J.; Patzer L.; Tsimaratos M.; Van'T Hoff W.G.; Yamaoka K.; Jentsch T.J.; Thakker R.V.
Characterization of renal chloride channel (CLCN5) mutations in Dent's disease
Journal of the American Society of Nephrology 11 (8): 1460-1468 (2000-08)



Jentsch T.J.; Schroeder B.C.; Kubisch C.; Friedrich T.; Stein V.
Pathophysiology of KCNQ channels: neonatal epilepsy and progressive deafness
Epilepsia 41 (8): 1068-1069 (2000-08)



Weinreich F.; Jentsch T.J.
Neurological diseases caused by ion-channel mutations
Current Opinion in Neurobiology 10 (3): 409-415 (2000-06)



Schwake M.; Pusch M.; Kharkovets T.; Jentsch T.J.
Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy
Journal of Biological Chemistry 275 (18): 13343-13348 (2000-05-05)



Kharkovets T.; Hardelin J.P.; Safieddine S.; Schweizer M.; El-Amraoui A.; Petit C.; Jentsch T.J.
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway
Proceedings of the National Academy of Sciences of the United States of America 97 (8): 4333-4338 (2000-04-11)



Selyanko A.A.; Hadley J.K.; Wood I.C.; Abogadie F.C.; Jentsch T.J.; Brown D.A.
Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors
Journal of Physiology 522 (Pt 3): 349-355 (2000-02-01)



Schroeder B.C.; Waldegger S.; Fehr S.; Bleich M.; Warth R.; Greger R.; Jentsch T.J.
A constitutively open potassium channel formed by KCNQ1 and KCNE3
Nature 403 (6766): 196-199 (2000-01-13)



1999

Schriever A.M.; Friedrich T.; Pusch M.; Jentsch T.J.
CLC chloride channels in Caenorhabditis elegans
Journal of Biological Chemistry 274 (48): 34238-34244 (1999-11-26)



Jentsch T.J.; Friedrich T.; Schriever A.; Yamada H.
The CLC chloride channel family
Pfluegers Archiv European Journal of Physiology 437 (6): 783-795 (1999-05)



Pusch M.; Jordt S.E.; Stein V.; Jentsch T.J.
Chloride dependence of hyperpolarization-activated chloride channel gates
Journal of Physiology 515 (Pt 2): 341-353 (1999-03-01)



Kubisch C.; Schroeder B.C.; Friedrich T.; Luetjohann B.; El-Amraoui A.; Marlin S.; Petit C.; Jentsch T.J.
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
Cell 96 (3): 437-446 (1999-02-05)



Friedrich T.; Breiderhoff T.; Jentsch T.J.
Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents
Journal of Biological Chemistry 274 (2): 896-902 (1999-01-08)



1998

Schroeder B.C.; Kubisch C.; Stein V.; Jentsch T.J.
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy
Nature 396 (6712): 687-690 (1998-12-17)



Igarashi T.; Guenther W.; Sekine T.; Inatomi J.; Shiraga H.; Takahashi S.; Suzuki J.; Tsuru N.; Yanagihara T.; Shimazu M.; Jentsch T.J.; Thakker R.V.
Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent'sJapan disease
Kidney International 54 (6): 1850-1856 (1998-12)



Steinlein O.K.; Jentsch T.J.
KCNQ2, the first gene found to be mutated in human generalized idiopathic epilepsy
Pathologie Biologie 46 (9): 683-684 (1998-11)



Kubisch C.; Schmidt-Rose T.; Fontaine B.; Bretag A.H.; Jentsch T.J.
ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence
Human Molecular Genetics 7 (11): 1753-1760 (1998-10)



Steinmeyer K.; Jentsch T.J.
Molecular physiology of renal chloride channels
Current Opinion in Nephrology and Hypertension 7 (5): 497-502 (1998-09)



Guenther W.; Luechow A.; Cluzeaud F.; Vandewalle A.; Jentsch T.J.
ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells
Proceedings of the National Academy of Sciences of the United States of America 95 (14): 8075-8080 (1998-07-07)



Schwappach B.; Stobrawa S.; Hechenberger M.; Steinmeyer K.; Jentsch T.J.
Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p
Journal of Biological Chemistry 273 (24): 15110-15108 (1998-06-12)



Rychkov G.Y.; Pusch M.; Roberts M.L.; Jentsch T.J.; Bretag A.H.
Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions
Journal of General Physiology 111 (5): 653-665 (1998-05)



Fong P.; Rehfeldt A.; Jentsch T.J.
Determinants of slow gating in ClC-0, the voltage-gated chloride channel of Torpedo marmorata
American Journal of Physiology 274 (4 Pt 1): C966-C973 (1998-04)



Plassart-Schiess E.; Gervais A.; Eymard B.; Lagueny A.; Pouget J.; Warter J.M.; Fardeau M.; Jentsch T.J.; Fontaine B.
Novel muscle chloride channel (CLCN1) mutations in myotonia congenita with various modes of inheritance including incomplete dominance and penetrance
Neurology 50 (4): 1176-1179 (1998-04)



Clark S.; Jordt S.E.; Jentsch T.J.; Mathie A.
Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons
Journal of Physiology 506 (Pt 3): 665-678 (1998-02-01)



Biervert C.; Schroeder B.C.; Kubisch C.; Berkovic S.F.; Propping P.; Jentsch T.J.; Steinlein O.K.
A potassium channel mutation in neonatal human epilepsy
Science 279 (5349): 403-406 (1998-01-16)



Kubisch C.; Wicklein E.M.; Jentsch T.J.
Molecular diagnosis of McArdle disease: revised genomic structure of the myophosphorylase gene and identification of a novel mutation
Human Mutation 12 (1): 27-32 (1998)



1997

Wollnik B.; Schroeder B.C.; Kubisch C.; Esperer H.D.; Wieacker P.; Jentsch T.J.
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias
Human Molecular Genetics 6 (11): 1943-1949 (1997-10)



Schmidt-Rose T.; Jentsch T.J.
Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1
Journal of Biological Chemistry 272 (33): 20515-20521 (1997-08-15)



Lloyd S.E.; Gunther W.; Pearce S.H.; Thomson A.; Bianchi M.L.; Bosio M.; Craig I.W.; Fisher S.E.; Scheinman S.J.; Wrong O.; Jentsch T.J.; Thakker R.V.
Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders
Human Molecular Genetics 6 (8): 1233-1239 (1997-08)



Ludewig U.; Pusch M.; Jentsch T.J.
Independent gating of single pores in CLC-0 chloride channels
Biophysical Journal 73 (2): 789-797 (1997-08)



Ludewig U.; Jentsch T.J.; Pusch M.
Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions
Journal of General Physiology 110 (2): 165-171 (1997-08)



Schmidt-Rose T.; Jentsch T.J.
Transmembrane topology of a CLC chloride channel
Proceedings of the National Academy of Sciences of the United States of America 94 (14): 7633-7638 (1997-07-08)



Vandewalle A.; Cluzeaud F.; Bens M.; Kieferle S.; Steinmeyer K.; Jentsch T.J.
Localization and induction by dehydration of ClC-K chloride channels in the rat kidney
American Journal of Physiology 272 (5 Pt 2): F678-F688 (1997-05)



Jordt S.E.; Jentsch T.J.
Molecular dissection of gating in the ClC-2 chloride channel
EMBO Journal 16 (7): 1582-1592 (1997-04-01)



Lloyd S.E.; Pearce S.H.; Guenther W.; Kawaguchi H.; Igarashi T.; Jentsch T.J.; Thakker R.V.
Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5)
Journal of Clinical Investigation 99 (5): 967-974 (1997-03-01)



Ludewig U.; Jentsch T.J.; Pusch M.
Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0
Journal of Physiology 498 (Pt 3): 691-702 (1997-02-01)



Pusch M.; Ludewig U.; Jentsch T.J.
Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels
Journal of General Physiology 109 (1): 105-116 (1997-01)



1996

Hechenberger M.; Schwappach B.; Fischer W.N.; Frommer W.B.; Jentsch T.J.; Steinmeyer K.
A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption
Journal of Biological Chemistry 271 (52): 33632-33638 (1996-12-27)



Rychkov G.Y.; Pusch M.; Astill D.S.; Roberts M.L.; Jentsch T.J.; Bretag A.H.
Concentration and pH dependence of skeletal muscle chloride channel ClC-1
Journal of Physiology 497 (Pt 2): 423-435 (1996-12-01)



Lorenz C.; Pusch M.; Jentsch T.J.
Heteromultimeric CLC chloride channels with novel properties
Proceedings of the National Academy of Sciences of the United States of America 93 (23): 13362-13366 (1996-11-12)



Ludewig U.; Pusch M.; Jentsch T.J.
Two physically distinct pores in the dimeric ClC-0 chloride channel
Nature 383 (6598): 340-343 (1996-09-26)



Staley K.; Smith R.; Schaack J.; Wilcox C.; Jentsch T.J.
Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel
Neuron 17 (3): 543-551 (1996-09)



Steinmeyer K.; Jentsch T.J.
Chloride Channel Myotonias
Neuroscientist 2 (4): 225-232 (1996-07)



Lloyd S.E.; Pearce S.H.; Fisher S.E.; Steinmeyer K.; Schwappach B.; Scheinman S.J.; Harding B.; Bolino A.; Devoto M.; Goodyer P.; Rigden S.P.; Wrong O.; Jentsch T.J.; Craig I.W.; Thakker R.V.
A common molecular basis for three inherited kidney stone diseases
Nature 379 (6564): 445-449 (1996-02-01)



1995

Steinmeyer K.; Schwappach B.; Bens M.; Vandewalle A.; Jentsch T.J.
Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease
Journal of Biological Chemistry 270 (52): 31172-31177 (1995-12-29)



Brandt S.; Jentsch T.J.
ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family
FEBS Letters 377 (1): 15-20 (1995-12-11)



Pusch M.; Steinmeyer K.; Koch M.C.; Jentsch T.J.
Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel
Neuron 15 (6): 1455-1463 (1995-12)



Meyer-Kleine C.; Steinmeyer K.; Ricker K.; Jentsch T.J.; Koch M.C.
Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia
American Journal of Human Genetics 57 (6): 1325-1334 (1995-12)



Lengeling A.; Gronemeier M.; Ronsiek M.; Thiemann A.; Jentsch T.J.; Jockusch H.
Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q
Genetical Research 66 (2): 175-178 (1995-10)



Fong P.; Jentsch T.J.
Molecular basis of epithelial Cl channels
Journal of Membrane Biology 144 (3): 189-197 (1995-04)



Pusch M.; Ludewig U.; Rehfeldt A.; Jentsch T.J.
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion
Nature 373 (6514): 527-531 (1995-02-09)



Jentsch T.J.; Guenther W.; Pusch M.; Schwappach B.
Properties of voltage-gated chloride channels of the ClC gene family
Journal of Physiology 482: 19S-25S (1995-01)



Jentsch T.J.; Lorenz C.; Pusch M.; Steinmeyer K.
Myotonias due to CLC-1 chloride channel mutations
Society of General Physiologists Series 50: 149-159 (1995)



1994

Klocke R.; Steinmeyer K.; Jentsch T.J.; Jockusch H.
Role of innervation, excitability, and myogenic factors in the expression of the muscular chloride channel ClC-1. A study on normal and myotonic muscle
Journal of Biological Chemistry 269 (44): 27635-27639 (1994-11-04)



Pusch M.; Jentsch T.J.
Molecular physiology of voltage-gated chloride channels
Physiological Reviews 74 (4): 813-827 (1994-10)



Jentsch T.J.
Molecular physiology of anion channels
Current Opinion in Cell Biology 6 (4): 600-606 (1994-08)



Kieferle S.; Fong P.; Bens M.; Vandewalle A.; Jentsch T.J.
Two highly homologous members of the ClC chloride channel family in both rat and human kidney
Proceedings of the National Academy of Sciences of the United States of America 91 (15): 6943-6947 (1994-07-19)



Lorenz C.; Meyer-Kleine C.; Steinmeyer K.; Koch M.C.; Jentsch T.J.
Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia
Human Molecular Genetics 3 (6): 941-946 (1994-06)



Gronemeier M.; Condie A.; Prosser J.; Steinmeyer K.; Jentsch T.J.; Jockusch H.
Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice
Journal of Biological Chemistry 269 (8): 5963-5967 (1994-02-25)



Steinmeyer K.; Lorenz C.; Pusch M.; Koch M.C.; Jentsch T.J.
Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen)
EMBO Journal 13 (4): 737-743 (1994-02-15)



Jentsch T.J.
Trinity of cation channels
Nature 367 (6462): 412-413 (1994-02-03)



Pusch M.; Steinmeyer K.; Jentsch T.J.
Low single channel conductance of the major skeletal muscle chloride channel, ClC-1
Biophysical Journal 66 (1): 149-152 (1994-01)



Jentsch T.J.
Structure and function of ClC chloride channels
Japanese Journal of Physiology 44 (Suppl 2): S1-S2 (1994)



Jentsch T.J.
Molecular biology of voltage-gated chloride channels
Current Topics in Membranes 42: 35-57 (1994)



1993

Jentsch T.J.; Pusch M.; Rehfeldt A.; Steinmeyer K.
The ClC family of voltage-gated chloride channels: structure and function
Annals of the New York Academy of Sciences 707: 285-293 (1993-12-20)



Koch M.C.; Ricker K.; Otto M.; Wolf F.; Zoll B.; Lorenz C.; Steinmeyer K.; Jentsch T.J.
Evidence for genetic homogeneity in autosomal recessive generalised myotonia (Becker)
Journal of Medical Genetics 30 (11): 914-917 (1993-11)



Jentsch T.J.
Chloride channels
Current Opinion in Neurobiology 3 (3): 316-321 (1993-06)



1992

Gruender S.; Thiemann A.; Pusch M.; Jentsch T.J.
Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume
Nature 360 (6406): 759-762 (1992-12-24)



Koch M.C.; Steinmeyer K.; Lorenz C.; Ricker K.; Wolf F.; Otto M.; Zoll B.; Lehmann-Horn F.; Grzeschik K.H.; Jentsch T.J.
The skeletal muscle chloride channel in dominant and recessive human myotonia
Science 257 (5071): 797-800 (1992-08-07)



Thiemann A.; Gruender S.; Pusch M.; Jentsch T.J.
A chloride channel widely expressed in epithelial and non-epithelial cells
Nature 356 (6364): 57-60 (1992-03-05)



1991

Bauer C.K.; Steinmeyer K.; Schwarz J.R.; Jentsch T.J.
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA
Proceedings of the National Academy of Sciences of the United States of America 88 (24): 11052-11056 (1991-12-15)



Steinmeyer K.; Klocke R.; Ortland C.; Gronemeier M.; Jockusch H.; Gruender S.; Jentsch T.J.
Inactivation of muscle chloride channel by transposon insertion in myotonic mice
Nature 354 (6351): 304-308 (1991-11-28)



Steinmeyer K.; Ortland C.; Jentsch T.J.
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel
Nature 354 (6351): 301-304 (1991-11-28)



1990

Jentsch T.J.; Steinmeyer K.; Schwarz G.
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes
Nature 348 (6301): 510-514 (1990-12-06)



Wiederholt M.; Jentsch T.J.
Cell culture of bovine corneal endothelial cells and its application to transport studies
Methods in Enzymology 192: 571-582 (1990)



1989

Jentsch T.J.; Garcia A.M.; Lodish H.F.
Primary structure of a novel 4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid (SITS)-binding membrane protein highly expressed in Torpedo californica electroplax
Biochemical Journal 261 (1): 155-166 (1989-07-01)



1988

Jentsch T.J.; Korbmacher C.; Janicke I.; Fischer D.G.; Stahl F.; Helbig H.; Hollwede H.; Cragoe E.J.; Keller S.K.; Wiederholt M.
Regulation of cytoplasmic pH of cultured bovine corneal endothelial cells in the absence and presence of bicarbonate
Journal of Membrane Biology 103 (1): 29-40 (1988-07)



Keller S.K.; Jentsch T.J.; Janicke I.; Wiederholt M.
Regulation of intracellular pH in cultured bovine retinal pigment epithelial cells
Pfluegers Archiv European Journal of Physiology 411 (1): 47-52 (1988-01)



1986

Jentsch T.J.; Matthes H.; Keller S.K.; Wiederholt M.
Electrical properties of sodium bicarbonate symport in kidney epithelial cells (BSC-1)
American Journal of Physiology 251 (6 Pt 2): F954-F968 (1986-12)



Jentsch T.J.; Janicke I.; Sorgenfrei D.; Keller S.K.; Wiederholt M.
The regulation of intracellular pH in monkey kidney epithelial cells (BSC-1). Roles of Na+/H+ antiport, Na+-HCO3(-)-(NaCO3-) symport, and Cl-/HCO3- exchange
Journal of Biological Chemistry 261 (26): 12120-12127 (1986-09-15)



Jentsch T.J.; Schwartz P.; Schill B.S.; Langner B.; Lepple A.P.; Keller S.K.; Wiederholt M.
Kinetic properties of the sodium bicarbonate (carbonate) symport in monkey kidney epithelial cells (BSC-1). Interactions between Na+, HCO-3, and pH
Journal of Biological Chemistry 261 (23): 10673-10679 (1986-08-15)



Keller S.K.; Jentsch T.J.; Koch M.; Wiederholt M.
Interactions of pH and K+ conductance in cultured bovine retinal pigment epithelial cells
American Journal of Physiology 250 (1 Pt 1): C124-C137 (1986-01)



1985

Jentsch T.J.; Schill B.S.; Schwartz P.; Matthes H.; Keller S.K.; Wiederholt M.
Kidney epithelial cells of monkey origin (BSC-1) express a sodium bicarbonate cotransport. Characterization by 22Na+ flux measurements
Journal of Biological Chemistry 260 (29): 15554-15560 (1985-12-15)



Jentsch T.J.; von der Haar B.; Keller S.K.; Wiederholt M.
Response of the intracellular potentials of cultured bovine lens cells to ions and inhibitors
Experimental Eye Research 41 (2): 131-144 (1985-08)



Drachsel W.; Jentsch T.J.; Gingerich K.A.; Block J.H.
Observation of doubly charged triatomic cluster ions in field evaporation
Surface Science 156 (Pt 1): 173-182 (1985-06-03)



Jentsch T.J.; Keller S.K.; Wiederholt M.
Ion transport mechanisms in cultured bovine corneal endothelial cells
Current Eye Research 4 (4): 361-369 (1985-04)



Wiederholt M.; Jentsch T.J.; Keller S.K.
Electrogenic sodium-bicarbonate symport in cultured corneal endothelial cells
Pfluegers Archiv European Journal of Physiology 405 (Suppl 1): S167-S171 (1985-03)



Jentsch T.J.; Matthes H.; Keller S.K.; Wiederholt M.
Anion dependence of electrical effects of bicarbonate and sodium on cultured bovine corneal endothelial cells
Pfluegers Archiv European Journal of Physiology 403 (2): 175-185 (1985-02)



Jentsch T.J.; Stahlknecht T.R.; Hollwede H.; Fischer D.G.; Keller S.K.; Wiederholt M.
A bicarbonate-dependent process inhibitable by disulfonic stilbenes and a Na+/H+ exchange mediate 22Na+ uptake into cultured bovine corneal endothelium
Journal of Biological Chemistry 260 (2): 795-801 (1985-01-25)



1984

Jentsch T.J.; Keller S.K.; Koch M.; Wiederholt M.
Evidence for coupled transport of bicarbonate and sodium in cultured bovine corneal endothelial cells
Journal of Membrane Biology 81 (3): 189-204 (1984-10)



Wiederholt M.; Keller S.; Krolik A.; Jentsch T.J.
The calcium antagonist nisoldipine stimulates the electrolyte transport of the isolated frog skin
Biochemical Pharmacology 33 (18): 2926-2928 (1984-09-15)



Jentsch T.J.; Koch M.; Bleckmann H.; Wiederholt M.
Effect of bicarbonate, pH, methazolamide and stilbenes on the intracellular potentials of cultured bovine corneal endothelial cells
Journal of Membrane Biology 78 (2): 103-117 (1984-06)



1983

Drachsel W.; Jentsch T.J.; Block J.H.
New techniques in surface specific mass analysis by photon induced field desorption
International Journal of Mass Spectrometry and Ion Physics 46: 293-296 (1983-01)



1982

Jentsch T.J.; Drachsel W.; Block J.H.
Stability of doubly charged homonuclear trimeric metal clusters
Chemical Physics Letters 93 (2): 144-147 (1982-11-26)



1981

Ernst N.; Jentsch T.J.
Post-field ionization of singly charged rhodium: An experimental and theoretical study
Physical Review B 24 (11): 6234-6241 (1981-07)



Block J.H.; Jentsch T.J.; Drachsel W.
Signal shapes observed in photon-induced field ionization mass spectra
International Journal of Mass Spectrometry and Ion Physics 38 (2-3): 195-213 (1981-05)



Jentsch T.J.; Drachsel W.; Block J.H.
Copper cluster ions in photon-induced field ionization mass spectra
International Journal of Mass Spectrometry and Ion Physics 38 (2-3): 215-222 (1981-05)