Publications



2017

Ferreira M.A.; Vonk J.M.; Baurecht H.; Marenholz I.; Tian C.; Hoffman J.D.; Helmer Q.; Tillander A.; Ullemar V.; van Dongen J.; Lu Yi; Rueschendorf F.; Esparza-Gordillo J.; Medway C.W.; Mountjoy E.; Burrows K.; Hummel O.; Grosche S.; Brumpton B.M.; Witte J.S.; Hottenga J.J.; Willemsen G.; Zheng J.; Rodriguez E.; Hotze M.; Franke A.; Revez J.A.; Beesley J.; Matheson M.C.; Dharmage S.C.; Bain L.M.; Fritsche L.G.; Gabrielsen M.E.; Balliu B.; Nielsen J.B.; Zhou W.; Hveem K.; Langhammer A.; Holmen O.L.; Loset M.; Abecasis G.R.; Willer C.J.; Arnold A.; Homuth G.; Schmidt C.O.; Thompson P.J.; Martin N.G.; Duffy D.L.; Novak N.; Schulz H.; Karrasch S.; Gieger C.; Strauch K.; Melles R.B.; Hinds D.A.; Huebner N.; Weidinger S.; Magnusson P.K.E.; Jansen R.; Jorgenson E.; Lee Y.A.; Boomsma D.I.; Almqvist C.; Karlsson R.; Koppelman G.H.; Paternoster L.
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Nature Genetics : (2017-10-30)



Marenholz I.; Grosche S.; Kalb B.; Rueschendorf F.; Bluemchen K.; Schlags R.; Harandi N.; Price M.; Hansen G.; Seidenberg J.; Roeblitz H.; Yuerek S.; Tschirner S.; Hong X.; Wang X.; Homuth G.; Schmidt C.O.; Noethen M.M.; Huebner N.; Niggemann B.; Beyer K.; Lee Y.A.
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy
Nature Communications 8 (1): 1056 (2017-10-20)



Nimptsch K.; Song M.; Aleksandrova K.; Katsoulis M.; Freisling H.; Jenab M.; Gunter M.J.; Tsilidis K.K.; Weiderpass E.; Bueno-De-Mesquita H.B.; Chong D.Q.; Jensen M.K.; Wu C.; Overvad K.; Kuehn T.; Barrdahl M.; Melander O.; Jirstrom K.; Peeters P.H.; Sieri S.; Panico S.; Cross A.J.; Riboli E.; Van Guelpen B.; Myte R.; Huerta J.M.; Rodriguez-Barranco M.; Quiros J.R.; Dorronsoro M.; Tjonneland A.; Olsen A.; Travis R.; Boutron-Ruault M.C.; Carbonnel F.; Severi G.; Bonet C.; Palli D.; Janke J.; Lee Y.A.; Boeing H.; Giovannucci E.L.; Ogino S.; Fuchs C.S.; Rimm E.; Wu K.; Chan A.T.; Pischon T.
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies
European Journal of Epidemiology 32 (5): 419-430 (2017-05)



Martino D.J.; Ashley S.; Koplin J.; Ellis J.; Saffery R.; Dharmage S.C.; Gurrin L.; Matheson M.C.; Kalb B.; Marenholz I.; Beyer K.; Lee Y.A.; Hong X.; Wang X.; Vukevic D.; Motyer A.; Leslie S.; Allen K.J.; Ferreira M.A.R.
Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1
Clinical and Experimental Allergy 47 (2): 217-223 (2017-02)



2016

Sarnowski C.; Laprise C.; Malerba G.; Moffatt M.F.; Dizier M.H.; Morin A.; Vincent Q.B.; Rohde K.; Esparza-Gordillo J.; Margaritte-Jeannin P.; Liang L.; Lee Y.A.; Bousquet J.; Siroux V.; Pignatti P.F.; Cookson W.O.; Lathrop M.; Pastinen T.; Demenais F.; Bouzigon E.
DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis
Journal of Allergy and Clinical Immunology 138 (3): 748-753 (2016-09)



Schmitt J.; Schwarz K.; Baurecht H.; Hotze M.; Foelster-Holst R.; Rodriguez E.; Lee Y.A.E.; Franke A.; Degenhardt F.; Lieb W.; Gieger C.; Kabesch M.; Noethen M.M.; Irvine A.D.; McLean W.H.I.; Deckert S.; Stephan V.; Schwarz P.; Aringer M.; Novak N.; Weidinger S.
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes
Journal of Allergy and Clinical Immunology 137 (1): 130-136 (2016-01)



2015

Paternoster L.; Standl M.; Waage J.; Baurecht H.; Hotze M.; Strachan D.P.; Curtin J.A.; Bonnelykke K.; Tian C.; Takahashi A.; Esparza-Gordillo J.; Alves A.C.; Thyssen J.P.; den Dekker H.T.; Ferreira M.A.; Altmaier E.; Sleiman P.M.A.; Xiao F.L.; Gonzalez J.R.; Marenholz I.; Kalb B.; Pino-Yanes M.; Xu C.J.; Carstensen L.; Groen-Blokhuis M.M.; Venturini C.; Pennell C.E.; Barton S.J.; Levin A.M.; Curjuric I.; Bustamante M.; Kreiner-Moller E.; Lockett G.A.; Bacelis J.; Bunyavanich S.; Myers R.A.; Matanovic A.; Kumar A.; Tung J.Y.; Hirota T.; Kubo M.; McArdle W.L.; Henderson A.J.; Kemp J.P.; Zheng J.; Smith G.D.; Rueschendorf F.; Bauerfeind A.; Lee-Kirsch M.A.; Arnold A.; Homuth G.; Schmidt C.O.; Mangold E.; Cichon S.; Keil T.; Rodriguez E.; Peters A.; Franke A.; Lieb W.; Novak N.; Foelster-Holst R.; Horikoshi M.; Pekkanen J.; Sebert S.; Husemoen L.L.; Grarup N.; de Jongste J.C.; Rivadeneira F.; Hofman A.; Jaddoe V.W.V.; Pasmans S.G.M.A.; Elbert N.J.; Uitterlinden A.G.; Marks G.B.; Thompson P.J.; Matheson M.C.; Robertson C.F.; Ried J.S.; Li J.; Zuo X.B.; Zheng X.D.; Yin X.Y.; Sun L.D.; McAleer M.A.; O'Regan G.M.; Fahy C.M.R.; Campbell L.E.; Macek M.; Kurek M.; Hu D.; Eng C.; Postma D.S.; Feenstra B.; Geller F.; Hottenga J.J.; Middeldorp C.M.; Hysi P.; Bataille V.; Spector T.; Tiesler C.M.T.; Thiering E.; Pahukasahasram B.; Yang J.J.; Imboden M.; Huntsman S.; Vilor-Tejedor N.; Relton C.L.; Myhre R.; Nystad W.; Custovic A.; Weiss S.T.; Meyers D.A.; Soederhaell C.; Melen E.; Ober C.; Raby B.A.; Simpson A.; Jacobsson B.; Holloway J.W.; Bisgaard H.; Sunyer J.; Probst-Hensch N.M.; Williams L.K.; Godfrey K.M.; Wang C.A.; Boomsma D.I.; Melbye M.; Koppelman G.H.; Jarvis D.; McLean W.H.I.; Irvine A.D.; Zhang X.J.; Hakonarson H.; Gieger C.; Burchard E.G.; Martin N.G.; Duijts L.; Linneberg A.; Jarvelin M.R.; Noethen M.M.; Lau S.; Huebner N.; Lee Y.A.; Tamari M.; Hinds D.A.; Glass D.; Brown S.J.; Heinrich J.; Evans D.M.; Weidinger S.
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Nature Genetics 47 (12): 1449-1456 (2015-12)



Marenholz I.; Esparza-Gordillo J.; Rueschendorf F.; Bauerfeind A.; Strachan D.P.; Spycher B.D.; Baurecht H.; Margaritte-Jeannin P.; Saeaef A.; Kerkhof M.; Ege M.; Baltic S.; Matheson M.C.; Li J.; Michel S.; Ang W.Q.; McArdle W.; Arnold A.; Homuth G.; Demenais F.; Bouzigon E.; Soederhaell C.; Pershagen G.; de Jongste J.C.; Postma D.S.; Braun-Fahrlaender C.; Horak E.; Ogorodova L.M.; Puzyrev V.P.; Bragina E.Y.; Hudson T.J.; Morin C.; Duffy D.L.; Marks G.B.; Robertson C.F.; Montgomery G.W.; Musk B.; Thompson P.J.; Martin N.G.; James A.; Sleiman P.; Toskala E.; Rodriguez E.; Foelster-Holst R.; Franke A.; Lieb W.; Gieger C.; Heinzmann A.; Rietschel E.; Keil T.; Cichon S.; Noethen M.M.; Pennell C.E.; Sly P.D.; Schmidt C.O.; Matanovic A.; Schneider V.; Heinig M.; Huebner N.; Holt P.G.; Lau S.; Kabesch M.; Weidinger S.; Hakonarson H.; Ferreira M.A.R.; Laprise C.; Freidin M.B.; Genuneit J.; Koppelman G.H.; Melen E.; Dizier M.H.; Henderson A.J.; Lee Y.A.
Meta-analysis identifies seven susceptibility loci involved in the atopic march
Nature Communications 6: 8804 (2015-11-06)



Grabenhenrich L.B.; Keil T.; Reich A.; Gough H.; Beschorner J.; Hoffmann U.; Bauer C.P.; Forster J.; Schuster A.; Schramm D.; Nitsche O.; Zepp F.; Lee Y.A.; Bergmann R.; Bergmann K.; Wahn U.; Lau S.
Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years
Journal of Allergy and Clinical Immunology 136 (4): 932–940.e12 (2015-10)



Marenholz I.; Esparza-Gordillo J.; Lee Y.A.
The genetics of the skin barrier in eczema and other allergic disorders
Current Opinion in Allergy and Clinical Immunology 15 (5): 426-434 (2015-10)



Schaarschmidt H.; Ellinghaus D.; Rodriguez E.; Kretschmer A.; Baurecht H.; Lipinski S.; Meyer-Hoffert U.; Harder J.; Lieb W.; Novak N.; Foelster-Holst R.; Esparza-Gordillo J.; Marenholz I.; Ruschendorf F.; Hubner N.; Reischl E.; Waldenberger M.; Gieger C.; Illig T.; Kabesch M.; Zhang X.J.; Xiao F.L.; Lee Y.A.; Franke A.; Weidinger S.
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis
Journal of Allergy and Clinical Immunology 136 (3): 802-806 (2015-09)



Nimptsch K.; Aleksandrova K.; Boeing H.; Janke J.; Lee Y.A.; Jenab M.; Yeon Kong S.; Tsilidis K.K.; Weiderpass E.; Bueno-De-Mesquita B.H.; Siersema P.D.; Jansen E.H.J.M.; Trichopoulou A.; Tjonneland A.; Olsen A.; Wu C.; Overvad K.; Boutron-Ruault M.C.; Racine A.; Freisling H.; Katzke V.; Kaaks R.; Lagiou P.; Trichopoulos D.; Severi G.; Naccarati A.; Mattiello A.; Palli D.; Grioni S.; Tumino R.; Peeters P.H.; Ljuslinder I.; Nystroem H.; Braendstedt J.; Sanchez M.J.; Barricarte Gurrea A.; Bonet Bonet C.; Chirlaque M.D.; Dorronsoro M.; Quiros J.R.; Travis R.C.; Khaw K.T.; Wareham N.; Riboli E.; Gunter M.J.; Pischon T.
Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer
International Journal of Cancer 137 (4): 911-920 (2015-08-15)



Gough H.; Grabenhenrich L.; Reich A.; Eckers N.; Nitsche O.; Schramm D.; Beschorner J.; Hoffmann U.; Schuster A.; Bauer C.P.; Forster J.; Zepp F.; Lee Y.A.; Bergmann R.L.; Bergmann K.E.; Wahn U.; Lau S.; Keil T.
Allergic multimorbidity of asthma, rhinitis, and eczema over 20 years in the German birth cohort MAS
Pediatric Allergy and Immunology 26 (5): 431-437 (2015-08)



Huang J.; Chen J.; Esparza J.; Ding J.; Elder J.T.; Abecasis G.R.; Lee Y.A.; Lathrop G.M.; Moffatt M.F.; Cookson W.O.C.; Liang L.
eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues
Nature Communications 6: 6821 (2015-05-08)



Esparza-Gordillo J.; Matanovic A.; Marenholz I.; Bauerfeind A.; Rohde K.; Nemat K.; Lee-Kirsch M.A.; Nordenskjoeld M.; Winge M.C.G.; Keil T.; Krueger R.; Lau S.; Beyer K.; Kalb B.; Niggemann B.; Huebner N.; Cordell H.J.; Bradley M.; Lee Y.A.
Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance
PLoS Genetics 11 (3): e1005076 (2015-03-10)



Nimptsch K.; Aleksandrova K.; Boeing H.; Janke J.; Lee Y.A.; Jenab M.; Bueno-De-Mesquita B.H.; Jansen E.H.J.M.; Tsilidis K.K.; Trichopoulou A.; Weiderpass E.; Wu C.; Overvad K.; Tjonneland A.; Boutron-Ruault M.C.; Dossus L.; Racine A.; Kaaks R.; Canzian F.; Lagiou P.; Trichopoulos D.; Palli D.; Agnoli C.; Tumino R.; Vineis P.; Panico S.; Johansson A.; VanGuelpen B.; Khaw K.T.; Wareham N.; Peeters P.H.; Quiros J.R.; Garcia A.V.; Molina-Montes E.; Dorronsoro M.; Chirlaque M.D.; Gurrea A.B.; Key T.J.; Duarte-Salles T.; Stepien M.; Gunter M.J.; Riboli E.; Pischon T.
Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk
International Journal of Cancer 136 (5): 1181-1192 (2015-03-01)



Baurecht H.; Hotze M.; Brand S.; Buening C.; Cormican P.; Corvin A.; Ellinghaus D.; Ellinghaus E.; Esparza-Gordillo J.; Foelster-Holst R.; Franke A.; Gieger C.; Hubner N.; Illig T.; Irvine A.D.; Kabesch M.; Lee Y.A.E.; Lieb W.; Marenholz I.; McLean W.H.I.; Morris D.W.; Mrowietz U.; Nair R.; Noethen M.M.; Novak N.; O'Regan G.M.; Schreiber S.; Smith C.; Strauch K.; Stuart P.E.; Trembath R.; Tsoi L.C.; Weichenthal M.; Barker J.; Elder J.T.; Weidinger S.; Cordell H.J.; Brown S.J.
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
American Journal of Human Genetics 96 (1): 104-120 (2015-01-08)



Guenther C.; Kind B.; Reijns M.A.M.; Berndt N.; Martinez-Bueno M.; Wolf C.; Tuengler V.; Chara O.; Lee Y.A.; Huebner N.; Bicknell L.; Blum S.; Krug C.; Schmidt F.; Kretschmer S.; Koss S.; Astell K.R.; Ramantani G.; Bauerfeind A.; Morris D.L.; Cunninghame Graham D.S.; Bubeck D.; Leitch A.; Ralston S.H.; Blackburn E.A.; Gahr M.; Witte T.; Vyse T.J.; Melchers I.; Mangold E.; Noethen M.M.; Aringer M.; Kuhn A.; Luethke K.; Unger L.; Bley A.; Lorenzi A.; Isaacs J.D.; Alexopoulou D.; Conrad K.; Dahl A.; Roers A.; Alarcon-Riquelme M.E.; Jackson A.P.; Lee-Kirsch M.A.
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
Journal of Clinical Investigation 125 (1): 413-424 (2015-01-02)



2014

Scholtens S.; Postma D.S.; Moffatt M.F.; Panasevich S.; Granell R.; Henderson A.J.; Melen E.; Nyberg F.; Pershagen G.; Jarvis D.; Ramasamy A.; Wjst M.; Svanes C.; Bouzigon E.; Demenais F.; Kauffmann F.; Siroux V.; von Mutius E.; Ege M.J.; Braun-Fahrlaender C.; Genuneit J.; Brunekreef B.; Smit H.A.; Wijga A.H.; Kerkhof M.; Curjuric I.; Imboden M.; Thun G.A.; Probst-Hensch N.; Freidin M.B.; Bragina E.I.; Deev I.A.; Puzyrev V.P.; Daley D.; Park J.; Becker A.; Chan-Yeung M.; Kozyrskyj A.L.; Pare P.; Marenholz I.; Lau S.; Keil T.; Lee Y.A.; Kabesch M.; Wijmenga C.; Franke L.; Nolte I.M.; Vonk J.; Kumar A.; Farrall M.; Cookson W.O.C.M.; Strachan D.P.; Koppelman G.H.; Boezen H.M.
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure
Journal of Allergy and Clinical Immunology 133 (3): 885-888 (2014-03)



2013

Saunders S.P.; Goh C.S.M.; Brown S.J.; Palmer C.N.A.; Porter R.M.; Cole C.; Campbell L.E.; Gierlinski M.; Barton G.J.; Schneider G.; Balmain A.; Prescott A.R.; Weidinger S.; Baurecht H.; Kabesch M.; Gieger C.; Lee Y.A.; Tavendale R.; Mukhopadhyay S.; Turner S.W.; Madhok V.B.; Sullivan F.M.; Relton C.; Burn J.; Meggitt S.; Smith C.H.; Allen M.A.; Barker J.N.W.N.; Reynolds N.J.; Cordell H.J.; Irvine A.D.; McLean W.H.I.; Sandilands A.; Fallon P.G.
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
Journal of Allergy and Clinical Immunology 132 (5): 1121-1129 (2013-11)



Marenholz I.; Esparza-Gordillo J.; Lee Y.A.
Shared genetic determinants between eczema and other immune-related diseases
Current Opinion in Allergy and Clinical Immunology 13 (5): 478-486 (2013-10)



Esparza-Gordillo J.; Schaarschmidt H.; Liang L.; Cookson W.; Bauerfeind A.; Lee-Kirsch M.A.; Nemat K.; Henderson J.; Paternoster L.; Harper J.L.; Mangold E.; Nothen M.M.; Rueschendorf F.; Kerscher T.; Marenholz I.; Matanovic A.; Lau S.; Keil T.; Bauer C.P.; Kurek M.; Ciechanowicz A.; Macek M.; Franke A.; Kabesch M.; Hubner N.; Abecasis G.; Weidinger S.; Moffatt M.; Lee Y.A.
A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis
Journal of Allergy and Clinical Immunology 132 (2): 371-377 (2013-08)



Baud A.; Hermsen R.; Guryev V.; Stridh P.; Graham D.; McBride M.W.; Foroud T.; Calderari S.; Diez M.; Ockinger J.; Beyeen A.D.; Gillett A.; Abdelmagid N.; Guerreiro-Cacais A.O.; Jagodic M.; Tuncel J.; Norin U.; Beattie E.; Huynh N.; Miller W.H.; Koller D.L.; Alam I.; Falak S.; Osborne-Pellegrin M.; Martinez-Membrives E.; Canete T.; Blazquez G.; Vicens-Costa E.; Mont-Cardona C.; Diaz-Moran S.; Tobena A.; Hummel O.; Zelenika D.; Saar K.; Patone G.; Bauerfeind A.; Bihoreau M.T.; Heinig M.; Lee Y.A.; Rintisch C.; Schulz H.; Wheeler D.A.; Worley K.C.; Muzny D.M.; Gibbs R.A.; Lathrop M.; Lansu N.; Toonen P.; Ruzius F.P.; de Bruijn E.; Hauser H.; Adams D.J.; Keane T.; Atanur S.S.; Aitman T.J.; Flicek P.; Malinauskas T.; Jones E.Y.; Ekman D.; Lopez-Aumatell R.; Dominiczak A.F.; Johannesson M.; Holmdahl R.; Olsson T.; Gauguier D.; Hubner N.; Fernandez-Teruel A.; Cuppen E.; Mott R.; Flint J.
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
Nature Genetics 45 (7): 767-775 (2013-07)



Ellinghaus D.; Baurecht H.; Esparza-Gordillo J.; Rodriguez E.; Matanovic A.; Marenholz I.; Huebner N.; Schaarschmidt H.; Novak N.; Michel S.; Maintz L.; Werfel T.; Meyer-Hoffert U.; Hotze M.; Prokisch H.; Heim K.; Herder C.; Hirota T.; Tamari M.; Kubo M.; Takahashi A.; Nakamura Y.; Tsoi L.C.; Stuart P.; Elder J.T.; Sun L.; Zuo X.; Yang S.; Zhang X.; Hoffmann P.; Noethen M.M.; Foelster-Holst R.; Winkelmann J.; Illig T.; Boehm B.O.; Duerr R.H.; Buening C.; Brandt S.; Glas J.; McAleer M.A.; Fahy C.M.; Kabesch M.; Brown S.; McLean W.H.I.; Irvine A.D.; Schreiber S.; Lee Y.A.; Franke A.; Weidinger S.
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
Nature Genetics 45 (7): 808-812 (2013-07)



Melen E.; Granell R.; Kogevinas M.; Strachan D.; Gonzalez J.R.; Wjst M.; Jarvis D.; Ege M.; Braun-Fahrlaender C.; Genuneit J.; Horak E.; Bouzigon E.; Demenais F.; Kauffmann F.; Siroux V.; Michel S.; von Berg A.; Heinzmann A.; Kabesch M.; Probst-Hensch N.M.; Curjuric I.; Imboden M.; Rochat T.; Henderson J.; Sterne J.A.C.; McArdle W.L.; Hui J.; James A.L.; William Musk A.; Palmer L.J.; Becker A.; Kozyrskyj A.L.; Chan-Young M.; Park J.E.; Leung A.; Daley D.; Freidin M.B.; Deev I.A.; Ogorodova L.M.; Puzyrev V.P.; Celedon J.C.; Brehm J.M.; Cloutier M.M.; Canino G.; Acosta-Perez E.; Soto-Quiros M.; Avila L.; Bergstroem A.; Magnusson J.; Soederhaell C.; Kull I.; Scholtens S.; Marike Boezen H.; Koppelman G.H.; Wijga A.H.; Marenholz I.; Esparza-Gordillo J.; Lau S.; Lee Y.A.; Standl M.; Tiesler C.M.; Flexeder C.; Heinrich J.; Myers R.A.; Ober C.; Nicolae D.L.; Farrall M.; Kumar A.; Moffatt M.F.; Cookson W.O.; Lasky-Su J.
Genome-wide association study of body mass index in 23 000 individuals with and without asthma
Clinical and Experimental Allergy 43 (4): 463-474 (2013-04)



2012

Dizier M.H.; Margaritte-Jeannin P.; Madore A.M.; Esparza-Gordillo J.; Moffatt M.F.; Corda E.; Monier F.; Guilloud-Bataille M.; Franke A.; Weidinger S.; Annesi-Maesano I.; Just J.; Pin I.; Kauffmann F.; Cookson W.; Lee Y.A.; Laprise C.; Lathrop M.; Bouzigon E.; Demenais F.
The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma
Journal of Allergy and Clinical Immunology 129 (6): 1547-1553 (2012-06)



Kuehnen P.; Mischke M.; Wiegand S.; Sers C.; Horsthemke B.; Lau S.; Keil T.; Lee Y.A.; Grueters A.; Krude H.
An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity
PLoS Genetics 8 (3): e1002543 (2012-03-15)



Knuppel S.; Esparza-Gordillo J.; Marenholz I.; Holzhutter H.; Bauerfeind A.; Ruether A.; Weidinger S.; Lee Y.A.; Rohde K.
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis
BMC Medical Genetics 13 (1): 8 (2012-01-27)



2011

Marenholz I.; Rivera V.A.; Esparza-Gordillo J.; Bauerfeind A.; Lee-Kirsch M.A.; Ciechanowicz A.; Kurek M.; Piskackova T.; Macek M.; Lee Y.A.
Association screening in the epidermal differentiation complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema
Journal of Investigative Dermatology 131 (8): 1644-1649 (2011-08)



Marenholz I.; Bauerfeind A.; Esparza-Gordillo J.; Kerscher T.; Granell R.; Nickel R.; Lau S.; Henderson J.; Lee Y.A.
The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever
Human Molecular Genetics 20 (12): 2443-2449 (2011-06-15)



2010

Esparza-Gordillo J.; Marenholz I.; Lee Y.A.
Genome-wide approaches to the etiology of eczema
Current Opinion in Allergy and Clinical Immunology 10 (5): 418-426 (2010-10)



Heinig M.; Petretto E.; Wallace C.; Bottolo L.; Rotival M.; Lu H.; Li Y.; Sarwar R.; Langley S.R.; Bauerfeind A.; Hummel O.; Lee Y.A.; Paskas S.; Rintisch C.; Saar K.; Cooper J.; Buchan R.; Gray E.E.; Cyster J.G.; Braund P.; Gracey J.; Krishnan U.; Moore J.S.; Nelson C.P.; Pollard H.; Attwood T.; Crisp-Hihn A.; Foad N.; Jolley J.; Lloyd-Jones H.; Muir D.; Murray E.; O'Leary K.; Rankin A.; Sambrook J.; Godfroy T.; Brocheton J.; Proust C.; Schmitz G.; Heimerl S.; Lugauer I.; Belz S.; Gulde S.; Linsel-Nitschke P.; Sager H.; Schroeder L.; Lundmark P.; Syvannen A.C.; Neudert J.; Scholz M.; Deloukas P.; Gray E.; Gwilliams R.; Niblett D.; Erdmann J.; Hengstenberg C.; Maouche S.; Ouwehand W.H.; Rice C.M.; Samani N.J.; Schunkert H.; Goodall A.H.; Schulz H.; Roider H.G.; Vingron M.; Blankenberg S.; Muenzel T.; Zeller T.; Szymczak S.; Ziegler A.; Tiret L.; Smyth D.J.; Pravenec M.; Aitman T.J.; Cambien F.; Clayton D.; Todd J.A.; Huebner N.; Cook S.A.
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Nature 467 (7314): 460-464 (2010-09-23)



2009

Marenholz I.; Lee Y.A.
Genetik des atopischen Ekzems: Neue Gene und Pathomechanismen [The genetics of atopic eczema: New genes and pathomechanisms]
Medizinische Genetik 21 (4): 493-497 (2009-12)



Dibbens L.M.; Mullen S.; Helbig I.; Mefford H.C.; Bayly M.A.; Bellows S.; Leu C.; Trucks H.; Obermeier T.; Wittig M.; Franke A.; Caglayan H.; Yapici Z.; Sander T.; Eichler E.E.; Scheffer I.E.; Mulley J.C.; Berkovic S.F.
Familial and sporadic 15q13.3 microdeletions in idiopathic generalized epilepsy: precedent for disorders with complex inheritance
Human Molecular Genetics 18 (19): 3626-3631 (2009-10-01)



Zitnik S.E.; Rueschendorf F.; Mueller S.; Sengler C.; Lee Y.A.; Griffioen R.W.; Meglio P.; Wahn U.; Witt H.; Nickel R.
IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis
Pediatric Allergy and Immunology 20 (6): 551-555 (2009-09)



Zucchelli M.; Torkvist L.; Bresso F.; Halfvarson J.; Soederhaell C.; Lee Y.A.; Loefberg R.; Kere J.; D'Amato M.
No association between the eczema genes COL29A1 and IL31 and inflammatory bowel disease
Inflammatory Bowel Diseases 15 (7): 961-962 (2009-07)



Mueller S.; Marenholz I.; Lee Y.A.; Sengler C.; Zitnik S.E.; Griffioen R.W.; Meglio P.; Wahn U.; Nickel R.
Association of filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the early treatment of the atopic child (ETAC) population
Pediatric Allergy and Immunology 20 (4): 358-361 (2009-06)



Esparza-Gordillo J.; Weidinger S.; Foelster-Holst R.; Bauerfeind A.; Rueschendorf F.; Patone G.; Rohde K.; Marenholz I.; Schulz F.; Kerscher T.; Huebner N.; Wahn U.; Schreiber S.; Franke A.; Vogler R.; Heath S.; Baurecht H.; Novak N.; Rodriguez E.; Illig T.; Lee-Kirsch M.A.; Ciechanowicz A.; Kurek M.; Piskackova T.; Macek M.; Lee Y.A.; Ruether A.
A common variant on chromosome 11q13 is associated with atopic dermatitis
Nature Genetics 41 (5): 596-601 (2009-05)



Beier K.C.; Humberdros S.; Witt H.; Illi S.; Rueschendorf F.; Nickel R.; Lee Y.A.; Lau S.; Wahn U.; Hamelmann E.
ICOS-gene variants are not associated with atopic disease susceptibility in European children
Pediatric Allergy and Immunology 20 (3): 242-245 (2009-05)



Marenholz I.; Kerscher T.; Bauerfeind A.; Esparza-Gordillo J.; Nickel R.; Keil T.; Lau S.; Rohde K.; Wahn U.; Lee Y.A.
An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma
Journal of Allergy and Clinical Immunology 123 (4): 911-916 (2009-04)



2008

Saar K.; Beck A.; Bihoreau M.T.; Birney E.; Brocklebank D.; Chen Y.; Cuppen E.; Demonchy S.; Dopazo J.; Flicek P.; Foglio M.; Fujiyama A.; Gut I.G.; Gauguier D.; Guigo R.; Guryev V.; Heinig M.; Hummel O.; Jahn N.; Klages S.; Kren V.; Kube M.; Kuhl H.; Kuramoto T.; Kuroki Y.; Lechner D.; Lee Y.A.; Lopez-Bigas N.; Lathrop G.M.; Mashimo T.; Medina I.; Mott R.; Patone G.; Perrier-Cornet J.A.; Platzer M.; Pravenec M.; Reinhardt R.; Sakaki Y.; Schilhabel M.; Schulz H.; Serikawa T.; Shikhagaie M.; Tatsumoto S.; Taudien S.; Toyoda A.; Voigt B.; Zelenika D.; Zimdahl H.; Huebner N.
SNP and haplotype mapping for genetic analysis in the rat
Nature Genetics 40 (5): 560-566 (2008-05)



Pasternack S.M.; von Kuegelgen I.; Aboud K.A.; Lee Y.A.; Rueschendorf F.; Voss K.; Hillmer A.M.; Molderings G.J.; Franz T.; Ramirez A.; Nuernberg P.; Noethen M.M.; Betz R.C.
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Nature Genetics 40 (3): 329-334 (2008-03)



2007

Schulz F.; Marenholz I.; Foelster-Holst R.; Chen C.; Sternjak A.; Baumgrass R.; Esparza-Gordillo J.; Grueber C.; Nickel R.; Schreiber S.; Stoll M.; Kurek M.; Rueschendorf F.; Huebner N.; Wahn U.; Lee Y.A.
A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
Journal of Allergy and Clinical Immunology 120 (5): 1097-1102 (2007-11)



Lee-Kirsch M.A.; Gong M.; Chowdhury D.; Senenko L.; Engel K.; Lee Y.A.; de Silva U.; Bailey S.L.; Witte T.; Vyse T.J.; Kere J.; Pfeiffer C.; Harvey S.; Wong A.; Koskenmies S.; Hummel O.; Rohde K.; Schmidt R.E.; Dominiczak A.F.; Gahr M.; Hollis T.; Perrino F.W.; Lieberman J.; Huebner N.
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Nature Genetics 39 (9): 1065-1067 (2007-09)



Soederhaell C.; Marenholz I.; Kerscher T.; Rueschendorf F.; Esparza-Gordillo J.; Worm M.; Gruber C.; Mayr G.; Albrecht M.; Rohde K.; Schulz H.; Wahn U.; Huebner N.; Lee Y.A.
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis
PLoS Biology 5 (9): e242 (2007-09)



2006

Ackermann G.E.; Marenholz I.; Wolfer D.P.; Chan W.Y.; Schaefer B.; Erne P.; Heizmann C.W.
S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses
Biochimica et Biophysica Acta - Molecular Cell Research 1763 (11): 1307-1319 (2006-11)



Marenholz I.; Nickel R.; Rueschendorf F.; Schulz F.; Esparza-Gordillo J.; Kerscher T.; Grueber C.; Lau S.; Worm M.; Keil T.; Kurek M.; Zaluga E.; Wahn U.; Lee Y.A.
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march
Journal of Allergy and Clinical Immunology 118 (4): 866-871 (2006-10)



Bu L.M.; Bradley M.; Soederhaell C.; Wahlgren C.F.; Kockum I.; Nordenskjoeld M.
Susceptibility loci for atopic dermatitis on chromosome 21 in a Swedish population
Allergy 61 (5): 617-621 (2006-05)



Bu L.M.; Bradley M.; Soederhaell C.; Wahlgren C.F.; Kockum I.; Nordenskjoeld M.
Genome-wide linkage analysis of allergic rhinoconjunctivitis in a Swedish population
Clinical and Experimental Allergy 36 (2): 204-210 (2006-02)



2005

Schumacher J.; Kaneva R.; Jamra R.A.; Diaz G.O.; Ohlraun S.; Milanova V.; Lee Y.A.; Rivas F.; Mayoral F.; Fuerst R.; Flaquer A.; Windemuth C.; Gay E.; Sanz S.; Gonzalez M.J.; Gil S.; Cabaleiro F.; del Rio F.; Perez F.; Haro J.; Kostov C.; Chorbov V.; Nikolova-Hill A.; Stoyanova V.; Onchev G.; Kremensky I.; Strauch K.; Schulze T.G.; Nuernberg P.; Gaebel W.; Klimke A.; Auburger G.; Wienker T.F.; Kalaydjieva L.; Propping P.; Cichon S.; Jablensky A.; Rietschel M.; Noethen M.M.
Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24
American Journal of Human Genetics 77 (6): 1102-1111 (2005-12-01)



Altmueller J.; Seidel C.; Lee Y.A.; Loesgen S.; Bulle D.; Friedrichs F.; Jellouschek H.; Kelber J.; Keller A.; Schuster A.; Silbermann M.; Wahlen W.; Wolff P.; Rueschendorf F.; Schlenvoigt G.; Nuernberg P.; Wjst M.
Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families
BMC Pulmonary Medicine 5: 1 (2005-01-05)



Soederhaell C.; Marenholz I.; Nickel R.; Grueber C.; Kehrt R.; Rohde K.; Griffioen R.W.; Meglio P.; Tarani L.; Gustafsson D.; Hoffmann U.; Gerstner B.; Mueller S.; Wahn U.; Lee Y.A.
Lack of association of the G protein-coupled receptor for asthma susceptibility gene with atopic dermatitis
Journal of Allergy and Clinical Immunology 116 (1): 220-221 (2005-01-01)



2004

Zimdahl H.; Nyakatura G.; Brandt P.; Schulz H.; Hummel O.; Fartmann B.; Brett D.; Droege M.; Monti J.; Lee Y.A.; Sun Y.Y.; Zhao S.Y.; Winter E.E.; Ponting C.P.; Chen Y.; Kasprzyk A.; Birney E.; Ganten D.; Huebner N.
A SNP map of the rat genome generated from cDNA sequences
Science 303 (5659): 807-807 (2004-01-01)



2003

Gong M.; Zhang H.Y.; Schulz H.; Lee Y.A.; Sun K.; Baehring S.; Luft F.C.; Nuernberg P.; Reis A.; Rohde K.; Ganten D.; Hui R.T.; Huebner N.
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p
Human Molecular Genetics 12 (11): 1273-1277 (2003-06-01)



2001

Betz R.C.; Schoser B.G.H.; Kasper D.; Ricker K.; Ramirez A.; Stein V.; Torbergsen T.; Lee Y.A.; Nothen M.M.; Wienker T.F.; Malin J.P.; Propping P.; Reis A.; Mortier W.; Jentsch T.J.; Vorgerd M.; Kubisch C.
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease
Nature Genetics 28 (3): 218-219 (2001-07)



1997

Lee M.A.; Cai L.; Huebner N.; Lee Y.A.; Lindpaintner K.
Tissue and development specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase
Journal of Clinical Investigation 100 (6): 1507-1512 (1997-09-15)



1995

Lee Y.A.; Huebner N.; Ganten D.
Genetische Analyse des Bluthochdrucks
Jahrbuch 1995 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale) : 323-333 (1995-01-01)