Publications



2017

Pahle J.; Menzel L.; Niesler N.; Kobelt D.; Aumann J.; Rivera M.; Walther W.
Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy
BMC Cancer 17 (1): 129 (2017-02-13)



Hoepken U.E.
Targeting HDAC3 in CREBBP-mutant lymphomas counterstrikes unopposed enhancer deacetylation of B-cell signaling and immune response genes
Cancer Discovery 7 (1): 14-16 (2017-01)



2016

Gaetjen M.; Brand F.; Grau M.; Gerlach K.; Kettritz R.; Westermann J.; Anagnostopoulos I.; Lenz P.; Lenz G.; Hoepken U.E.; Rehm A.
Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia.
Cancer Research 76 (18): 5253-5265 (2016-09)



Stauss D.; Brunner C.; Berberich-Siebelt F.; Hoepken U.E.; Lipp M.; Mueller G.
The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6
EMBO Journal 35 (8): 881-898 (2016-04-15)



Wichner K.; Stauss D.; Kampfrath B.; Krueger K.; Mueller G.; Rehm A.; Lipp M.; Hoepken U.E.
Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of ROR{gamma}t
FASEB Journal 30 (2): 761-774 (2016-02)



2015

Schachtner H.; Weimershaus M.; Stache V.; Plewa N.; Legler D.F.; Hoepken U.E.; Maritzen T.
Loss of Gadkin affects dendritic cell migration in vitro
PLoS ONE 10 (12): e0143883 (2015-12-01)



Oden F.; Marino S.F.; Brand J.; Scheu S.; Kriegel C.; Olal D.; Takvorian A.; Westermann J.; Yilmaz B.; Hinz M.; Daumke O.; Hoepken U.E.; Mueller G.; Lipp M.
Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma
Molecular Oncology 9 (7): 1348-1358 (2015-08)



2014

Heinig K.; Gaetjen M.; Grau M.; Stache V.; Anagnostopoulos I.; Gerlach K.; Niesner R.A.; Cseresnyes Z.; Hauser A.E.; Lenz P.; Hehlgans T.; Brink R.; Westermann J.; Doerken B.; Lipp M.; Lenz G.; Rehm A.; Hoepken U.E.
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation
Cancer Discovery 4: 1448-1465 (2014-12)



Hoepken U.E.
Lymphotoxin-{alpha} keeps the gate open for T-cell infiltration in cHL
Blood 124 (19): 2897-2898 (2014-11-06)



Rehm A.; Gaetjen M.; Gerlach K.; Scholz F.; Mensen A.; Gloger M.; Heinig K.; Lamprecht B.; Mathas S.; Begay V.; Leutz A.; Lipp M.; Doerken B.; Hoepken U.E.
Dendritic cell-mediated survival signals in E{my}-Myc B-cell lymphoma depend on the transcription factor C/EBP{beta}
Nature Communications 5: 5057 (2014-09-30)



Turqueti-Neves A.; Otte M.; da Costa O.P.; Hoepken U.E.; Lipp M.; Buch T.; Voehringer D.
B-cell-intrinsic STAT6 signaling controls germinal center formation
European Journal of Immunology 44 (7): 2130-2138 (2014-07)



Halvorsen B.; Dahl T.B.; Smedbakken L.M.; Singh A.; Michelsen A.E.; Skjelland M.; Krohg-Sorensen K.; Russell D.; Hoepken U.E.; Lipp M.; Damas J.K.; Holm S.; Yndestad A.; Biessen E.A.; Aukrust P.
Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells
Cardiovascular Research 102 (1): 148-156 (2014-04-01)



2013

Wichner K.; Fischer A.; Winter S.; Tetzlaff S.; Heimesaat M.M.; Bereswill S.; Rehm A.; Lipp M.; Hoepken U.E.
Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and ROR{gamma}t double-deficient mice is dependent on gut microbiota
Journal of Autoimmunity 47: 58-72 (2013-12)



2012

Herda S.; Raczkowski F.; Mittruecker H.W.; Willimsky G.; Gerlach K.; Kuehl A.A.; Breiderhoff T.; Willnow T.E.; Doerken B.; Hoepken U.E.; Rehm A.
The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-{gamma} and granzyme A in T cells
Immunity 37 (5): 854-866 (2012-11-16)



Hoepken U.E.; Rehm A.
Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs
Journal of Molecular Medicine 90 (11): 1237-1245 (2012-11)



Schumann M.; Winter S.; Wichner K.; May C.; Kuehl A.A.; Batra A.; Siegmund B.; Zeitz M.; Schulzke J.D.; Lipp M.; Hoepken U.E.
CCR7 deficiency causes diarrhea associated with altered ion transport in colonocytes in the absence of overt colitis
Mucosal Immunology 5 (4): 377-387 (2012-07)



2011

Winter S.; Rehm A.; Wichner K.; Scheel T.; Batra A.; Siegmund B.; Berek C.; Lipp M.; Hoepken U.E.
Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice
American Journal of Pathology 179 (2): 754-765 (2011-08)



Rehm A.; Mensen A.; Schradi K.; Gerlach K.; Wittstock S.; Winter S.; Buechner G.; Doerken B.; Lipp M.; Hoepken U.E.
Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs
Blood 118 (4): 1020-1033 (2011-07-28)



2010

Winter S.; Loddenkemper C.; Aebischer A.; Raebel K.; Hoffmann K.; Meyer T.F.; Lipp M.; Hoepken U.E.
The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation
Journal of Molecular Medicine 88 (11): 1169-1180 (2010-11)



Hoepken U.E.; Winter S.; Achtman A.H.; Krueger K.; Lipp M.
CCR7 regulates lymphocyte egress and recirculation through body cavities
Journal of Leukocyte Biology 87 (4): 671-682 (2010-04)



2009

Rehm A.; Anagnostopoulos I.; Gerlach K.; Broemer M.; Scheidereit C.; Joehrens K.; Huebler M.; Hetzer R.; Stein H.; Lipp M.; Doerken B.; Hoepken U.E.
Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma
International Journal of Cancer 125 (10): 2367-2374 (2009-11-15)



van de Pavert S.A.; Olivier B.J.; Goverse G.; Vondenhoff M.F.; Greuter M.; Beke P.; Kusser K.; Hoepken U.E.; Lipp M.; Niederreither K.; Blomhoff R.; Sitnik K.; Agace W.W.; Randall T.D.; de Jonge W.J.; Mebius R.E.
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
Nature Immunology 10 (11): 1193-1199 (2009-11)



Rueder C.; Hoepken U.E.; Wolf J.; Mittruecker H.W.; Engels B.; Erdmann B.; Wollenzin S.; Uckert W.; Doerken B.; Rehm A.
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells
Journal of Clinical Investigation 119 (8): 2184-2203 (2009-08)



Achtman A.H.; Hoepken U.E.; Bernert C.; Lipp M.
CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens
Journal of Leukocyte Biology 85 (3): 409-417 (2009-03)



2007

Wengner A.M.; Hoepken U.E.; Petrow P.K.; Hartmann S.; Schurigt U.; Braeuer R.; Lipp M.
CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis
Arthritis and Rheumatism 56 (10): 3271-3283 (2007-10)



Westermann J.; Nguyen-Hoai T.; Baldenhofer G.; Hoepken U.E.; Lipp M.; Doerken B.; Pezzutto A.
CCL19 (ELC) as an adjuvant for DNA vaccination: induction of a TH1-type T-cell response and enhancement of antitumor immunity
Cancer Gene Therapy 14 (6): 523-532 (2007-06)



Menning A.; Hoepken U.E.; Siegmund K.; Lipp M.; Hamann A.; Huehn J.
Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets
European Journal of Immunology 37 (6): 1575-1583 (2007-06)



Hoepken U.E.; Wengner A.M.; Loddenkemper C.; Stein H.; Heimesaat M.M.; Rehm A.; Lipp M.
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity
Blood 109 (3): 886-895 (2007-02-01)



Kahnert A.; Hoepken U.E.; Stein M.; Bandermann S.; Lipp M.; Kaufmann S.H.
Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs
Journal of Infectious Diseases 195 (1): 46-54 (2007-01-01)



2006

Zhao C.; Wood M.W.; Galyov E.E.; Hoepken U.E.; Lipp M.; Bodmer H.C.; Tough D.F.; Carter R.W.
Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo
European Journal of Immunology 36 (11): 2939-2950 (2006-11)



2005

Hoepken U.E.; Lehmann I.; Droese J.; Lipp M.; Schueler T.; Rehm A.
The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion
European Journal of Immunology 35 (10): 2851-2863 (2005-09-23)



Kursar M.; Hoepken U.E.; Koch M.; Koehler A.; Lipp M.; Kaufmann S.H.; Mittruecker H.W.
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection
Journal of Experimental Medicine 201 (9): 1447-1457 (2005-05-02)



2004

Droese J.; Mokros T.; Hermosilla R.; Schuelein R.; Lipp M.; Hoepken U.E.; Rehm A.
HCMV-encoded chemokine receptor US28 employs multiple routes for internalization
Biochemical and Biophysical Research Communications 322 (1): 42-49 (2004-09-10)



Hoepken U.E.; Achtman A.H.; Krueger K.; Lipp M.
Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens
Journal of Leukocyte Biology 76 (3): 709-718 (2004-09)



Hoepken U.E.; Lipp M.
All roads lead to rome: triggering dendritic cell migration
Immunity 20 (3): 244-246 (2004-03)



Hoepken U.E.; Droese J.; Li J.P.; Joergensen J.; Breitfeld D.; Zerwes H.G.; Lipp M.
The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses
European Journal of Immunology 34 (2): 461-470 (2004-01-01)



2003

Mueller G.; Hoepken U.E.; Lipp M.
The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity
Immunological Reviews 195 (1): 117-135 (2003-10)



Martin-Fontecha A.; Sebastiani S.; Hoepken U.E.; Uguccioni M.; Lipp M.; Lanzavecchia A.; Sallusto F.
Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming
Journal of Experimental Medicine 198 (4): 615-621 (2003-08-18)



Mueller G.; Reiterer P.; Hoepken U.E.; Golfier S.; Lipp M.
Role of homeostatic chemokine and sphingosine-1-phosphate receptors in the organization of lymphoid tissue
Annals of the New York Academy of Sciences 987: 107-116 (2003-04)



2002

Mueller G.; Hoepken U.E.; Stein H.; Lipp M.
Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors
Journal of Leukocyte Biology 72 (1): 1-8 (2002-07)



Hoepken U.E.; Foss H.D.; Meyer D.; Hinz M.; Leder K.; Stein H.; Lipp M.
Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs
Blood 99 (4): 1109-1116 (2002-01-01)



Mokros T.; Rehm A.; Droese J.; Oppermann M.; Lipp M.; Hoepken U.E.
Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation
Journal of Biological Chemistry 277 (47): 45122-45128 (2002-01-01)



Ueno T.; Hara K.; Willis M.S.; Malin M.A.; Hoepken U.E.; Gray D.H.D.; Matsushima K.; Lipp M.; Springer T.A.; Boyd R.L.; Yoshie O.; Takahama Y.
Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus
Immunity 16 (2): 205-218 (2002-01-01)



1999

Osaka H.; McGinty A.; Hoepken U.E.; Lu B.; Gerard C.; Pasinetti G.M.
Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration
Neuroscience 88 (4): 1073-1082 (1999-02)



1998

Mohr M.; Hoepken U.; Oppermann M.; Mathes C.; Goldmann K.; Siever S.; Goetze O.; Burchardi H.
Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis
European Journal of Clinical Investigation 28 (3): 227-234 (1998-03)



1997

Hoepken U.E.; Lu B.; Gerard N.P.; Gerard C.
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor
Journal of Experimental Medicine 186 (5): 749-756 (1997-08-29)



Heesen M.; Berman M.A.; Hoepken U.E.; Gerard N.P.; Dorf M.E.
Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1{alpha} is a ligand for both CXC chemokine receptor-4 isoforms
Journal of Immunology 158 (8): 3561-3564 (1997-04-15)



1996

Bozic C.R.; Lu B.; Hoepken U.E.; Gerard C.; Gerard N.P.
Neurogenic amplification of immune complex inflammation
Science 273 (5282): 1722-1725 (1996-09-20)



Hoepken U.E.; Lu B.; Gerard N.P.; Gerard C.
The C5a chemoattractant receptor mediates mucosal defence to infection
Nature 383 (6595): 86-89 (1996-09-05)



Hoepken U.; Mohr M.; Strueber A.; Montz H.; Burchardi H.; Goetze O.; Oppermann M.
Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies
European Journal of Immunology 26 (5): 1103-1109 (1996-05)