Signal Transduction in Tumor Cells
Head of the Group
Prof. Dr. Claus Scheidereit
31.1: Max Delbrück House (Hochbau)
Our laboratory is interested in signal transduction processes that activate the inducible transcription factor nuclear factor-κB (NF-κB) as well as in regulatory mechanisms that control the activity of NF-κB in the nucleus.
NF-κB and its regulators provide an excellent model system with broad physiological and medical significance. The transcription factor controls important steps in immunity and inflammation, as well as cell death, proliferation or metabolism. Its activity is controlled by inhibitory IκB proteins and the IκB kinase (IKK) complex.
We wish to decipher mechanisms that underlie gene regulation by IKK and NF-κB in development and diseases. To reach these goals, we are utilizing a wide variety of approaches, including classical biochemistry, mouse-models, 3D optimal imaging, systems biology, genome-wide target gene determination and siRNA screening as well as mass spectrometry (MS)-based proteomics.