Publications



2017

Stope M.B.; Dansranjavin T.; Erb H.; Erdmann K.; Fendler A.; Hoelters S.; Juengel E.; Nitschke K.; Salomo K.; Seidel P.; Skowron M.A.; Wach S.; Becker C.
UroFors: Konstituierung eines Interessensverbundes fuer Naturwissenschaftler in der urologischen Forschung [UroFors: establishment of an interest group for natural scientists in urological research]
Urologe : (2017-02-20)



Valenti G.; Quinn H.M.; Heynen G.J.J.E.; Lan L.; Holland J.D.; Vogel R.; Wulf-Goldenberg A.; Birchmeier W.
Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors
Cancer Research : (2017-02-15)



2016

Fendler A.; Stephan C.; Yousef G.M.; Kristiansen G.; Jung K.
The translational potential of microRNAs as biofluid markers of urological tumours
Nature Reviews Urology 13 (12): 734-752 (2016-12)



Qi J.; Yu Y.; Akilli Oeztuerk O.; Holland J.D.; Besser D.; Fritzmann J.; Wulf-Goldenberg A.; Eckert K.; Fichtner I.; Birchmeier W.
New Wnt/{beta}-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals
Gut 65 (10): 1690-1701 (2016-10)



Thomas J.J.; Abed M.; Heuberger J.; Novak R.; Zohar Y.; Beltra-Lopez A.P.; Trausch-Azar J.S.; Ilagan M.X.G.; Benhamou D.; Dittmar G.; Kopan R.; Birchmeier W.; Schwartz A.L.; Orian A.
RNF4-dependent oncogene activation by protein stabilization
Cell Reports 16 (12): 3388-3400 (2016-09-20)



Dema A.; Schroeter M.F.; Perets E.; Skroblin P.; Moutty M.C.; Deak V.A.; Birchmeier W.; Klussmann E.
The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3{beta} interaction protein (GSKIP) regulates {beta}-catenin through its interactions with both protein kinase A (PKA) and GSK3{beta}
Journal of Biological Chemistry 291 (37): 19618-19630 (2016-09-09)



Birchmeier W.
Orchestrating Wnt signalling for metabolic liver zonation
Nature Cell Biology 18 (5): 463-465 (2016-05)



Momeny M.; Ghasemi R.; Valenti G.; Miranda M.; Zekri A.; Zarrinrad G.; Javadikooshesh S.; Yaghmaie M.; Alimoghaddam K.; Ghavamzadeh A.; Ghaffari S.H.
Effects of silibinin on growth and invasive properties of human ovarian carcinoma cells through suppression of heregulin/HER3 pathway
Tumor Biology 37 (3): 3913-3923 (2016-03)



Fang L.; Zhu Q.; Neuenschwander M.; Specker E.; Wulf-Goldenberg A.; Weis W.I.; von Kries J.P.; Birchmeier W.
A small-molecule antagonist of the {beta}-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis
Cancer Research 76 (4): 891-901 (2016-02-15)



Winter A.; Sigurdardottir A.G.; DiCara D.; Valenti G.; Blundell T.L.; Gherardi E.
Developing antagonists for the Met-HGF/SF protein-protein interaction using a fragment-based approach
Molecular Cancer Therapeutics 15 (1): 3-14 (2016-01)



2015

Akilli Oeztuerk O.; Pakula H.; Chmielowiec J.; Qi J.; Stein S.; Lan L.; Sasaki Y.; Rajewsky K.; Birchmeier W.
Gab1 and Mapk signaling are essential in the hair cycle and hair follicle stem cell quiescence
Cell Reports 13 (3): 561-572 (2015-10-20)



Busch J.; Ralla B.; Jung M.; Wotschofsky Z.; Trujillo-Arribas E.; Schwabe P.; Kilic E.; Fendler A.; Jung K.
Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas
Journal of Experimental & Clinical Cancer Research 34 (1): 61 (2015-06-14)



Lan L.; Holland J.D.; Qi J.; Grosskopf S.; Rademann J.; Vogel R.; Gyoerffy B.; Wulf-Goldenberg A.; Birchmeier W.
Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice
EMBO Journal 34 (11): 1493-1508 (2015-06-03)



Grigoryan T.; Birchmeier W.
Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system
BioEssays 37 (5): 502-513 (2015-05)



Grosskopf S.; Eckert C.; Arkona C.; Radetzki S.; Boehm K.; Heinemann U.; Wolber G.; von Kries J.P.; Birchmeier W.; Rademann J.
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo
ChemMedChem 10 (5): 815-826 (2015-05)



Momeny M.; Saunus J.M.; Marturana F.; McCart Reed A.E.; Black D.; Sala G.; Iacobelli S.; Holland J.D.; Yu D.; Da Silva L.; Simpson P.T.; Khanna K.K.; Chenevix-Trench G.; Lakhani S.R.
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines
Oncotarget 6 (6): 3932-3946 (2015-02-19)



Ueberham E.; Glockner P.; Gohler C.; Straub B.K.; Teupser D.; Schonig K.; Braeuning A.; Hohn A.K.; Jerchow B.; Birchmeier W.; Gaunitz F.; Arendt T.; Sansom O.; Gebhardt R.; Ueberham U.
Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a negative tumors
Molecular Cancer Research 13 (2): 239-249 (2015-02)



2014

Yoshida T.; Iwata T.; Takai Y.; Birchmeier W.; Yamato M.; Okano T.
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice
Genes to Cells 19 (11): 842-852 (2014-11)



Zatula N.; Wiese M.; Bunzendahl J.; Birchmeier W.; Perske C.; Bleckmann A.; Brembeck F.H.
The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis
Oncotarget 5 (16): 6770-6787 (2014-08-30)



Simonetti M.; Agarwal N.; Stoesser S.; Bali K.K.; Karaulanov E.; Kamble R.; Pospisilova B.; Kurejova M.; Birchmeier W.; Niehrs C.; Heppenstall P.; Kuner R.
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways
Neuron 83 (1): 104-121 (2014-07-02)



Heuberger J.; Kosel F.; Qi J.; Grossmann K.S.; Rajewsky K.; Birchmeier W.
Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine
Proceedings of the National Academy of Sciences of the United States of America 111 (9): 3472-3477 (2014-03-04)



Sheean M.E.; McShane E.; Cheret C.; Walcher J.; Mueller T.; Wulf-Goldenberg A.; Hoelper S.; Garratt A.N.; Krueger M.; Rajewsky K.; Meijer D.; Birchmeier W.; Lewin G.R.; Selbach M.; Birchmeier C.
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination
Genes & Development 28 (3): 290-303 (2014-02-01)



2013

Holland J.D.; Gyoerffy B.; Vogel R.; Eckert K.; Valenti G.; Fang L.; Lohneis P.; Elezkurtaj S.; Ziebold U.; Birchmeier W.
Combined Wnt/{beta}-catenin, met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome
Cell Reports 5 (5): 1214-1227 (2013-12-12)



Grigoryan T.; Stein S.; Qi J.; Wende H.; Garratt A.N.; Nave K.A.; Birchmeier C.; Birchmeier W.
Wnt/Rspondin/{beta}-catenin signals control axonal sorting and lineage progression in Schwann cell development
Proceedings of the National Academy of Sciences of the United States of America 110 (45): 18174-18179 (2013-11-05)



Lichner Z.; Fendler A.; Saleh C.; Nasser A.N.; Boles D.; Al-Haddad S.; Kupchak P.; Dharsee M.; Nuin P.S.; Evans K.R.; Jung K.; Stephan C.; Fleshner N.E.; Yousef G.M.
MicroRNA signature helps distinguish early from late biochemical failure in prostate cancer
Clinical Chemistry 59 (11): 1595-1603 (2013-11)



Augustin I.; Gross J.; Baumann D.; Korn C.; Kerr G.; Grigoryan T.; Mauch C.; Birchmeier W.; Boutros M.
Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis
Journal of Experimental Medicine 210 (9): 1761-1777 (2013-08-26)



Wend P.; Fang L.; Zhu Q.; Schipper J.H.; Loddenkemper C.; Kosel F.; Brinkmann V.; Eckert K.; Hindersin S.; Holland J.D.; Lehr S.; Kahn M.; Ziebold U.; Birchmeier W.
Wnt/{beta}-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours
EMBO Journal 32 (14): 1977-1989 (2013-07-17)



Holland J.D.; Klaus A.; Garratt A.N.; Birchmeier W.
Wnt signaling in stem and cancer stem cells
Current Opinion in Cell Biology 25 (2): 254-264 (2013-04)



2012

Cerrone M.; Noorman M.; Lin X.; Chkourko H.; Liang F.X.; van der Nagel R.; Hund T.; Birchmeier W.; Mohler P.; van Veen T.A.; van Rijen H.V.; Delmar M.
Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency
Cardiovascular Research 95 (4): 460-468 (2012-09-01)



Smith E.S.J.; Purfuerst B.; Grigoryan T.; Park T.J.; Bennett N.C.; Lewin G.R.
Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of bathyergidae
Journal of Comparative Neurology 520 (12): 2785-2803 (2012-08-15)



Rosario M.; Schuster S.; Juettner R.; Parthasarathy S.; Tarabykin V.; Birchmeier W.
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin
Genes & Development 26 (15): 1743-1757 (2012-08-01)



Klaus A.; Mueller M.; Schulz H.; Saga Y.; Martin J.F.; Birchmeier W.
Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells
Proceedings of the National Academy of Sciences of the United States of America 109 (27): 10921-10926 (2012-07-03)



Blackburn J.; Ohazama A.; Kawasaki K.; Otsuka-Tanaka Y.; Liu B.; Honda K.; Rountree R.B.; Hu Y.; Kawasaki M.; Birchmeier W.; Schmidt-Ullrich R.; Kinoshita A.; Schutte B.C.; Hammond N.L.; Dixon M.J.; Sharpe P.T.
The role of Irf6 in tooth epithelial invagination
Developmental Biology 365 (1): 61-70 (2012-05-01)



Gherardi E.; Birchmeier W.; Birchmeier C.; Woude G.V.
Targeting MET in cancer: rationale and progress
Nature Reviews Cancer 12 (2): 89-103 (2012-02)



Spagnoli F.M.; Besser D.; Benitah S.A.
Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells
EMBO Reports 13 (1): 9-11 (2012-01)



2011

Willecke R.; Heuberger J.; Grossmann K.; Michos O.; Schmidt-Ott K.; Walentin K.; Costantini F.; Birchmeier W.
The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney
Developmental Biology 360 (2): 310-307 (2011-12-15)



Brembeck F.H.; Wiese M.; Zatula N.; Grigoryan T.; Dai Y.; Fritzmann J.; Birchmeier W.
BCL9-2 promotes early stages of intestinal tumor progression
Gastroenterology 141 (4): 1359-1370 (2011-10)



Birchmeier W.
Stem cells: Orphan receptors find a home
Nature 476 (7360): 287-288 (2011-08-18)



Redmer T.; Diecke S.; Grigoryan T.; Quiroga-Negreira A.; Birchmeier W.; Besser D.
E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming
EMBO Reports 12 (7): 720-726 (2011-07-01)



Kuerbitz C.; Heise D.; Redmer T.; Goumas F.; Arlt A.; Lemke J.; Rimbach G.; Kalthoff H.; Trauzold A.
Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells
Cancer Science 102 (4): 728-734 (2011-04)



2010

Juerchott K.; Kuban R.J.; Krech T.; Bluethgen N.; Stein U.; Walther W.; Friese C.; Kielbasa S.M.; Ungethuem U.; Lund P.; Knoesel T.; Kemmner W.; Morkel M.; Fritzmann J.; Schlag P.M.; Birchmeier W.; Krueger T.; Sperling S.; Sers C.; Royer H.D.; Herzel H.; Schaefer R.
Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells
PLoS Genetics 6 (12): e1001231 (2010-12-02)



Wend P.; Holland J.D.; Ziebold U.; Birchmeier W.
Wnt signaling in stem and cancer stem cells
Seminars in Cell & Developmental Biology 21 (8): 855-863 (2010-10)



Chirasani S.R.; Sternjak A.; Wend P.; Momma S.; Campos B.; Herrmann I.M.; Graf D.; Mitsiadis T.; Herold-Mende C.; Besser D.; Synowitz M.; Kettenmann H.; Glass R.
Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells
Brain 133 (Pt 7): 1961-1972 (2010-07)



Haurie V.; Durrieu-Gaillard S.; Dumay-Odelot H.; Da Silva D.; Rey C.; Prochazkova M.; Roeder R.G.; Besser D.; Teichmann M.
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation
Proceedings of the National Academy of Sciences of the United States of America 107 (9): 4176-4181 (2010-03-02)



Heuberger J.; Birchmeier W.
Interplay of cadherin-mediated cell adhesion and canonical wnt signaling
Cold Spring Harbor Perspectives in Biology 2 (2): a002915 (2010-02)



Talamillo A.; Delgado I.; Nakamura T.; de-Vega S.; Yoshitomi Y.; Unda F.; Birchmeier W.; Yamada Y.; Ros M.A.
Role of Epiprofin, a zinc-finger transcription factor, in limb development
Developmental Biology 337 (2): 363-374 (2010-01-15)



Grossmann K.S.; Rosario M.; Birchmeier C.; Birchmeier W.
The tyrosine phosphatase Shp2 in development and cancer
Advances in Cancer Research 106: 53-89 (2010)



2009

Wijk N.V.; Witte F.; Feike A.C.; Schambony A.; Birchmeier W.; Mundlos S.; Stricker S.
The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling
Biochemical and Biophysical Research Communications 390 (2): 211-216 (2009-12-11)



Grossmann K.S.; Wende H.; Paul F.E.; Cheret C.; Garratt A.N.; Zurborg S.; Feinberg K.; Besser D.; Schulz H.; Peles E.; Selbach M.; Birchmeier W.; Birchmeier C.
The tyrosine phosphatase Shp2 (PTPN11) directs neuregulin-1/ErbB signaling throughout schwann cell development
Proceedings of the National Academy of Sciences of the United States of America 106 (39): 16704-16709 (2009-09-29)



Zhang Y.; Tomann P.; Andl T.; Gallant N.M.; Huelsken J.; Jerchow B.; Birchmeier W.; Paus R.; Piccolo S.; Mikkola M.L.; Morrisey E.E.; Overbeek P.A.; Scheidereit C.; Millar S.E.; Schmidt-Ullrich R.
Reciprocal requirements for EDA/EDAR/NF-{kappa}B and Wnt/{beta}-catenin signaling pathways in hair follicle induction
Developmental Cell 17 (1): 49-61 (2009-07-21)



Fritzmann J.; Morkel M.; Besser D.; Budczies J.; Kosel F.; Brembeck F.H.; Stein U.; Fichtner I.; Schlag P.M.; Birchmeier W.
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential
Gastroenterology 137 (11): 165-175 (2009-07)



Klaus A.; Birchmeier W.
Developmental signaling in myocardial progenitor cells: A comprehensive view of Bmp- and Wnt/beta-catenin signaling
Pediatric Cardiology 30 (5): 609-616 (2009-07)



Suzuki K.; Yamaguchi Y.; Villacorte M.; Mihara K.; Akiyama M.; Shimizu H.; Taketo M.M.; Nakagata N.; Tsukiyama T.; Yamaguchi T.P.; Birchmeier W.; Kato S.; Yamada G.
Embryonic hair follicle fate change by augmented {beta}-catenin through Shh and Bmp signaling
Development 136 (3): 367-372 (2009-02)



Stein U.; Walther W.; Arlt F.; Schwabe H.; Smith J.; Fichtner I.; Birchmeier W.; Schlag P.M.
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
Nature Medicine 15 (1): 59-67 (2009-01)



2008

Kaufman W.L.; Kocman I.; Agrawal V.; Rahn H.P.; Besser D.; Gossen M.
Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation
Nucleic Acids Research 36 (17): e111 (2008-10)



Grigoryan T.; Wend P.; Klaus A.; Birchmeier W.
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice
Genes & Development 22 (17): 2308-2341 (2008-09-01)



Diecke S.; Quiroga-Negreira A.; Redmer T.; Besser D.
FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cells
Cells Tissues Organs 188 (1-2): 52-61 (2008-07)



Hellmuth K.; Grosskopf S.; Lum C.T.; Wuertele M.; Roeder N.; von Kries J.P.; Rosario M.; Rademann J.; Birchmeier W.
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
Proceedings of the National Academy of Sciences of the United States of America 105 (20): 7275-7280 (2008-05-20)



Klaus A.; Birchmeier W.
Wnt signalling and its impact on development and cancer
Nature Reviews Cancer 8 (5): 387-398 (2008-05)



Malanchi I.; Peinado H.; Kassen D.; Hussenet T.; Metzger D.; Chambon P.; Huber M.; Hohl D.; Cano A.; Birchmeier W.; Huelsken J.
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
Nature 452 (7187): 650-653 (2008-04-03)



Naerhi K.; Jaervinen E.; Birchmeier W.; Taketo M.M.; Mikkola M.L.; Thesleff I.
Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation
Development 135 (6): 1019-1028 (2008-03)



Jeannet G.; Scheller M.; Scarpellino L.; Duboux S.; Gardiol N.; Back J.; Kuttler F.; Malanchi I.; Birchmeier W.; Leutz A.; Huelsken J.; Held W.
Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
Blood 111 (1): 142-149 (2008-01-01)



2007

Klaus A.; Saga Y.; Taketo M.M.; Tzahor E.; Birchmeier W.
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis
Proceedings of the National Academy of Sciences of the United States of America 104 (47): 18531-18536 (2007-11-20)



Schaeper U.; Vogel R.; Chmielowiec J.; Huelsken J.; Rosario M.; Birchmeier W.
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
Proceedings of the National Academy of Sciences of the United States of America 104 (39): 15376-15381 (2007-09-25)



Rosario M.; Franke R.; Bednarski C.; Birchmeier W.
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
Journal of Cell Biology 178 (3): 503-516 (2007-07-30)



Koch A.; Hrychyk A.; Hartmann W.; Waha A.; Mikeska T.; Waha A.; Schueller U.; Soerensen N.; Berthold F.; Goodyer C.G.; Wiestler O.D.; Birchmeier W.; Behrens J.; Pietsch T.
Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
International Journal of Cancer 121 (2): 284-291 (2007-07-15)



Baurand A.; Zelarayan L.; Betney R.; Gehrke C.; Dunger S.; Noack C.; Busjahn A.; Huelsken J.; Taketo M.M.; Birchmeier W.; Dietz R.; Bergmann M.W.
Beta-catenin downregulation is required for adaptive cardiac remodeling
Circulation Research 100 (9): 1353-1362 (2007-05-11)



Hosking C.R.; Ulloa F.; Hogan C.; Ferber E.; Figueroa A.; Gevaert K.; Birchmeier W.; Briscoe J.; Fujita Y.
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin
Molecular Biology of the Cell 18 (5): 1918-1927 (2007-05-01)



Chmielowiec J.; Borowiak M.; Morkel M.; Stradal T.; Munz B.; Werner S.; Wehland J.; Birchmeier C.; Birchmeier W.
c-Met is essential for wound healing in the skin
Journal of Cell Biology 177 (1): 151-162 (2007-04-09)



Faraldo M.M.; Teuliere J.; Deugnier M.A.; Birchmeier W.; Huelsken J.; Thiery J.P.; Cano A.; Glukhova M.A.
Beta-catenin regulates P-cadherin expression in mammary basal epithelial cells
FEBS Letters 581 (5): 831-836 (2007-03-06)



Zechner D.; Mueller T.; Wende H.; Walther I.; Taketo M.M.; Crenshaw E.B.; Treier M.; Birchmeier W.; Birchmeier C.
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons
Developmental Biology 303 (1): 181-190 (2007-03-01)



2006

Jaervinen E.; Salazar-Ciudad I.; Birchmeier W.; Taketo M.M.; Jernvall J.; Thesleff I.
Continuous tooth generation in mouse is induced by activated epithelial Wnt/{beta}-catenin signaling
Proceedings of the National Academy of Sciences of the United States of America 103 (49): 18627-18632 (2006-12-05)



Stein U.; Arlt F.; Walther W.; Smith J.; Waldman T.; Harris E.D.; Mertins S.D.; Heizmann C.W.; Allard D.; Birchmeier W.; Schlag P.M.; Shoemaker R.H.
The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer
Gastroenterology 131 (5): 1486-1500 (2006-11)



Moeller H.; Jenny A.; Schaeffer H.J.; Schwarz-Romond T.; Mlodzik M.; Hammerschmidt M.; Birchmeier W.
Diversin regulates heart formation and gastrulation movements in development
Proceedings of the National Academy of Sciences of the United States of America 103 (43): 15900-15905 (2006-10-24)



Scheller M.; Huelsken J.; Rosenbauer F.; Taketo M.M.; Birchmeier W.; Tenen D.G.; Leutz A.
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
Nature Immunology 7 (10): 1037-1047 (2006-10)



Hadjihannas M.V.; Brueckner M.; Jerchow B.; Birchmeier W.; Dietmaier W.; Behrens J.
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer
Proceedings of the National Academy of Sciences of the United States of America 103 (28): 10747-10752 (2006-07-11)



MacRae C.A.; Birchmeier W.; Thierfelder L.
Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism
Journal of Clinical Investigation 116 (7): 1825-1828 (2006-07)



Hill T.P.; Taketo M.M.; Birchmeier W.; Hartmann C.
Multiple roles of mesenchymal beta-catenin during murine limb patterning
Development 133 (7): 1219-1229 (2006-04-01)



Brembeck F.H.; Rosario M.; Birchmeier W.
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin
Current Opinion in Genetics & Development 16 (1): 51-59 (2006-02)



Soshnikova N.; Birchmeier W.
Limb development
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1 : 976-981 (2006)



Schaeper U.; Grossmann K.S.
Tyrosine kinases
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1951-1959 (2006)



2005

Hirrlinger J.; Moeller H.; Kirchhoff F.; Dringen R.
Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell rt-PCR study
Neurochemical Research 30 (10): 1237-1244 (2005-10-01)



Stelzl U.; Worm U.; Lalowski M.; Haenig C.; Brembeck F.H.; Goehler H.; Stroedicke M.; Zenkner M.; Schoenherr A.; Koeppen S.; Timm J.; Mintzlaff S.; Abraham C.; Bock N.; Kietzmann S.; Goedde A.; Toksoez E.; Droege A.; Krobitsch S.; Korn B.; Birchmeier W.; Lehrach H.; Wanker E.E.
A human protein-protein interaction network: a resource for annotating the proteome
Cell 122 (6): 957-968 (2005-09-23)



Pullikuth A.; McKinnon E.; Schaeffer H.J.; Catling A.D.
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals
Molecular and Cellular Biology 25 (12): 5119-5133 (2005-06-01)



Hill T.P.; Spaeter D.; Taketo M.M.; Birchmeier W.; Hartmann C.
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
Developmental Cell 8 (5): 727-738 (2005-05-01)



Shu W.; Guttentag S.; Wang Z.; Andl T.; Ballard P.; Lu M.M.; Piccolo S.; Birchmeier W.; Whitsett J.A.; Millar S.E.; Morrisey E.E.
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
Developmental Biology 283 (1): 226-239 (2005-01-01)



Birchmeier W.
Cell adhesion and signal transduction in cancer
EMBO Reports 6 (5): 413-417 (2005-01-01)



Yu H.M.; Jerchow B.; Sheu T.J.; Liu B.; Costantini F.; Puzas J.E.; Birchmeier W.; Hsu W.
The role of Axin2 in calvarial morphogenesis and craniosynostosis
Development 132 (8): 1995-2005 (2005-01-01)



Sharma C.; Vomastek T.; Tarcsafalvi A.; Catling A.D.; Schaeffer H.J.; Eblen S.T.; Weber M.J.
MEK Partner 1 (MP1): Regulation of oligomerization in MAP kinase signaling
Journal of Cellular Biochemistry 94 (4): 708-719 (2005-01-01)



Schaeper U.; Birchmeier W.
HGF/SF c-Met signaling in the epithelial-mesenchymal transition and migration of muscle progenitor cells
Cell Migration in Development and Disease : 191-204 (2005-01-01)



2004

Schuetz G.; Rosario M.; Grimm J.; Boeckers T.M.; Gundelfinger E.D.; Birchmeier W.
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
Journal of Cell Biology 167 (5): 945-952 (2004-12-06)



Gerull B.; Heuser A.; Wichter T.; Paul M.; Basson C.T.; McDermott D.A.; Lerman B.B.; Markowitz S.M.; Ellinor P.T.; MacRae C.A.; Peters S.; Grossmann K.S.; Drenckhahn J.; Michely B.; Sasse-Klaassen S.; Birchmeier W.; Dietz R.; Breithardt G.; Schulze-Bahr E.; Thierfelder L.
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy
Nature Genetics 36 (11): 1162-1164 (2004-11)



Grossmann K.S.; Grund C.; Huelsken J.; Behrend M.; Erdmann B.; Franke W.W.; Birchmeier W.
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Journal of Cell Biology 167 (1): 149-160 (2004-10-11)



Teuliere J.; Faraldo M.M.; Shtutman M.; Birchmeier W.; Huelsken J.; Thiery J.P.; Glukhova M.A.
beta-catenin-dependent and -independent effects of deltaN-plakoglobin on epidermal growth and differentiation
Molecular and Cellular Biology 24 (19): 8649-8661 (2004-10-01)



Brembeck F.H.; Schwarz-Romond T.; Bakkers J.; Wilhelm S.; Hammerschmidt M.; Birchmeier W.
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions
Genes & Development 18 (18): 2225-2230 (2004-09-15)



Rosario M.; Birchmeier W.
Making tubes: Step by step
Developmental Cell 7 (1): 3-5 (2004-07-01)



Zechner D.; Soshnikova N.; Birchmeier W.
Deciphering the function of signaling pathways by tissue specific gene modification in mice
Zellbiologie Aktuell 30 (1): 6-8 (2004-01)



Besser D.
Expression of nodal, lefty-A, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3
Journal of Biological Chemistry 279 (43): 45076-45084 (2004-01-01)



Hogan C.; Serpente N.; Cogram P.; Hosking C.R.; Bialucha C.U.; Feller S.M.; Braga V.M.M.; Birchmeier W.; Fujita Y.
Rap1 regulates the formation of E-cadherin-based cell-cell contacts
Molecular and Cellular Biology 24 (15): 6690-6700 (2004-01-01)



van den Akker E.; van Dijk T.; Parren-van Amelsvoort M.; Grossmann K.S.; Schaeper U.; Toney-Earley K.; Waltz S.E.; Loewenberg B.; von Lindern M.
Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors
Blood 103 (12): 4457-4465 (2004-01-01)



Lamothe B.; Yamada M.; Schaeper U.; Birchmeier W.; Lax I.; Schlessinger J.
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway
Molecular and Cellular Biology 24 (13): 5657-5666 (2004-01-01)



Koch A.; Weber N.; Waha A.; Hartmann W.; Denkhaus D.; Behrens J.; Birchmeier W.; von Schweinitz D.; Pietsch T.
Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas
Journal of Pathology 204 (5): 546-554 (2004-01-01)



2003

Birchmeier C.; Birchmeier W.; Gherardi E.; Vande Woude G.F.
Met, metastasis, motility and more
Nature Reviews Molecular Cell Biology 4 (12): 915-925 (2003-12)



Bamji S.X.; Shimazu K.; Kimes N.; Huelsken J.; Birchmeier W.; Lu B.; Reichardt L.F.
Role of {beta}-catenin in synaptic vesicle localization and presynaptic assembly
Neuron 40 (4): 719-731 (2003-11)



Mucenski M.L.; Wert S.E.; Nation J.M.; Loudy D.E.; Huelsken J.; Birchmeier W.; Morrisey E.E.; Whitsett J.A.
{beta}-catenin is required for specification of proximal/distal cell fate during lung morphogenesis
Journal of Biological Chemistry 278 (41): 40231-40238 (2003-10-10)



Zechner D.; Fujita Y.; Huelsken J.; Mueller T.; Walther I.; Taketo M.M.; Crenshaw E.B.; Birchmeier W.; Birchmeier C.
beta-catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
Developmental Biology 258 (2): 406-418 (2003-06-15)



Rosario M.; Birchmeier W.
How to make tubes: signaling by the Met receptor tyrosine kinase
Trends in Cell Biology 13 (6): 328-335 (2003-06)



Churin Y.; Al Ghoul L.; Kepp O.; Meyer T.E.; Birchmeier W.; Naumann M.
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
Journal of Cell Biology 161 (2): 249-255 (2003-04-28)



Soshnikova N.; Zechner D.; Huelsken J.; Mishina Y.; Behringer R.R.; Taketo M.M.; Crenshaw E.B.; Birchmeier W.
Genetic interaction between Wnt/{beta}-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Genes & Development 17 (16): 1963-1968 (2003-01-01)



Morkel M.; Huelsken J.; Wakamiya M.; Ding J.; van de Wetering M.; Clevers H.; Taketo M.M.; Behringer R.R.; Shen M.M.; Birchmeier W.
{beta}-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Development 130 (25): 6283-6294 (2003-01-01)



Xu Y.; Banerjee D.; Huelsken J.; Birchmeier W.; Sen J.M.
Deletion of beta-catenin impairs T cell development
Nature Immunology 4 (12): 1177-1182 (2003-01-01)



2002

Schwarz-Romond T.; Asbrand C.; Bakkers J.; Kuehl M.; Schaeffer H.J.; Huelsken J.; Behrens J.; Hammerschmidt M.; Birchmeier W.
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling
Genes & Development 16 (16): 2073-2084 (2002-08-15)



Wong M.H.; Huelsken J.; Birchmeier W.; Gordon J.I.
Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuehn is perturbed by stimulation of Lef-1/{beta}-catenin signaling
Journal of Biological Chemistry 277 (18): 15843-15850 (2002-05-03)



Fujita Y.; Krause G.; Scheffner M.; Zechner D.; Leddy H.E.M.; Behrens J.; Sommer T.; Birchmeier W.
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
Nature Cell Biology 4 (3): 222-231 (2002-03-01)



Lustig B.; Jerchow B.; Sachs M.; Weiler S.; Pietsch T.; Karsten U.; van de Wetering M.; Clevers H.; Schlag P.M.; Birchmeier W.; Behrens J.
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
Molecular and Cellular Biology 22 (4): 1184-1193 (2002-02-01)



Niemann C.; Owens D.M.; Huelsken J.; Birchmeier W.; Watt F.M.
Expression of deltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Development 129: 95-109 (2002-01-01)



Kurz S.M.; Diebold S.S.; Hieronymus T.; Gust T.C.; Bartunek P.; Sachs M.; Birchmeier W.; Zenke M.
The impact of c-met/scatter factor receptor on dendritic cell migration
European Journal of Immunology 32 (7): 1832-1838 (2002-01-01)



2001

Huelsken J.; Birchmeier W.
New aspects of Wnt signaling pathways in higher vertebrates
Current Opinion in Genetics & Development 11 (5): 547-553 (2001-10-01)



Grimm J.; Sachs M.; Britsch S.; Di Cesare S.; Schwarz-Romond T.; Birchmeier W.
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation
Journal of Cell Biology 154 (2): 345-354 (2001-07-23)



Huelsken J.; Vogel R.; Erdmann B.; Cotsarelis G.; Birchmeier W.
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Cell 105 (4): 533-545 (2001-05-18)



Keilhack H.; Mueller M.; Boehmer S.A.; Frank C.; Weidner K.M.; Birchmeier W.; Ligensa T.; Berndt A.; Kosmehl H.; Gunther B.; Mueller T.; Birchmeier C.; Boehmer F.D.
Negative regulation of Ros receptor tyrosine kinase signaling: An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1
Journal of Cell Biology 152 (2): 325-334 (2001-01-22)



Schmidt-Ullrich R.; Aebischer T.; Huelsken J.; Birchmeier W.; Klemm U.; Scheidereit C.
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
Development 128 (19): 3843-3853 (2001-01-01)



Dahmen R.P.; Koch A.; Denkhaus D.; Tonn J.C.; Soerensen N.; Berthold F.; Behrens J.; Birchmeier W.; Wiestler O.D.; Pietsch T.
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas
Cancer Research 61: 7039-7043 (2001-01-01)



Lewitzky M.; Kardinal C.; Gehring N.H.; Schmidt E.K.; Konkol B.; Eulitz M.; Birchmeier W.; Schaeper U.; Feller S.M.
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif
Oncogene 20 (9): 1052-1062 (2001-01-01)



2000

Smits R.; Ruiz P.; Diaz-Cano S.; Luz A.; Jagmohan-Changur S.; Breukel C.; Birchmeier C.; Birchmeier W.; Fodde R.
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice
Gastroenterology 119 (4): 1045-1053 (2000-10-01)



Honeck H.; Gross V.; Erdmann B.; Kaergel E.; Neunaber R.; Milia A.F.; Schneider W.; Luft F.C.; Schunck W.H.
Cytochrome P450-dependent renal arachidonic acid metabolism in desoxycorticosterone acetate-salt hypertensive mice
Hypertension 36: 610-616 (2000-10-01)



Sachs M.; Brohmann H.; Zechner D.; Mueller T.; Huelsken J.; Walther I.; Schaeper U.; Birchmeier C.; Birchmeier W.
Essential role of Gab1 for signaling by the c-Met receptor in vivo
Journal of Cell Biology 150 (6): 1375-1384 (2000-09-18)



Schaeper U.; Gehring N.H.; Fuchs K.P.; Sachs M.; Kempkes B.; Birchmeier W.
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
Journal of Cell Biology 149 (7): 1419-1432 (2000-06-26)



Behrens J.
Control of beta-catenin signaling in tumor development
Annals of the New York Academy of Sciences 910: 21-35 (2000-06)



Sakkab D.; Lewitzky M.; Posern G.; Schaeper U.; Sachs M.; Birchmeier W.; Feller S.M.
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
Journal of Biological Chemistry 275 (15): 10772-10778 (2000-04-14)



Huelsken J.; Vogel R.; Brinkmann V.; Erdmann B.; Birchmeier C.; Birchmeier W.
Requirement for beta-catenin in anterior-posterior axis formation in mice
Journal of Cell Biology 148 (3): 567-578 (2000-02-07)



Niemann C.; Brinkmann V.; Birchmeier W.
Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis
Advances in Experimental Medicine and Biology 480: 9-18 (2000-01-01)



von Kries J.P.; Winbeck G.; Asbrand C.; Schwarz-Romond T.; Sochnikova N.; Dell'Oro A.; Behrens J.; Birchmeier W.
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
Nature Structural Biology 7: 800-807 (2000-01-01)



1999

Lichtner R.B.; Parczyk K.; Birchmeier W.; Schneider M.R.
Differential cross-talk of estrogen and growth factor receptors in two human mammary tumor cell lines
Journal of Steroid Biochemistry and Molecular Biology 71 (5-6): 181-189 (1999-12-31)



Handschuh G.; Candidus S.; Luber B.; Reich U.; Schott C.; Oswald S.; Becke H.; Hutzler P.; Birchmeier W.; Hoefler H.; Becker K.F.
Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility
Oncogene 18: 4301-4312 (1999-07-29)



Birchmeier W.
Hot papers in cell biology - J. Behrens, J.P. von Kries, M. Kuehl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier: "Functional interaction of beta-catenin with the transcription factor LEF-1" - Comments by Walter Birchmeier
Scientist 13(8): 15 (1999-04-12)



Birchmeier W.
Introduction
Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins : 121-125 (1999)



Birchmeier W.; Birchmeier C.
Epithelial Morphogenesis in Development and Disease
: (1999-01-01)



Birchmeier W.; Birchmeier C.; Brinkmann V.; Niemann C.
10. Tyrosine kinase receptors as driving forces for growth, motility and differentiation of epithelial cells
Epithelial Morphogenesis in Development and Disease : 217-231 (1999-01-01)



Ghadimi B.M.; Behrens J.; Hoffmann I.; Haensch W.; Birchmeier W.; Schlag P.M.
Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: Implications for cell adhesion and signaling
European Journal of Cancer 35 (1): 60-65 (1999-01)



Isac C.M.; Ruiz P.; Pfitzmaier B.; Haase H.; Birchmeier W.; Morano I.
Plakoglobin is essential for myocardial compliance but dispensable for myofibril insertion into adherens junctions
Journal of Cellular Biochemistry 72 (1): 8-15 (1999-01-01)



1998

Niemann C.; Brinkmann V.; Spitzer E.; Hartmann G.; Sachs M.; Naundorf H.; Birchmeier W.
Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis
Journal of Cell Biology 143 (2): 533-545 (1998-10-19)



Behrens J.; Jerchow B.A.; Wuertele M.; Grimm J.; Asbrand C.; Wirtz R.; Kuehl M.; Wedlich D.; Birchmeier W.
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
Science 280 (5363): 596-599 (1998-04-24)



Ruiz P.; Birchmeier W.
The plakoglobin knock-out mouse: A paradigm for the molecular analysis of cardiac cell junction formation
Trends in Cardiovascular Medicine 8 (3): 97-101 (1998-04)



Hartmann G.; Prospero T.; Brinkmann V.; Ozcelik O.; Winter G.; Hepple J.; Batley S.; Bladt F.; Sachs M.; Birchmeier C.; Birchmeier W.; Gherardi E.
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo
Current Biology 8 (3): 125-134 (1998-01-29)



Sommer W.; Cui X.; Erdmann B.; Wiklund L.; Bricca G.; Heilig M.; Fuxe K.
The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain
Antisense and Nucleic Acid Drug Development 8: 75-85 (1998-01-01)



Lin S.; Rusciano D.; Lorenzoni P.; Hartmann G.; Birchmeier W.; Giordano S.; Comoglio P.; Burger M.M.
C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells
Clinical and Experimental Metastasis 16: 253-265 (1998-01-01)



Schwechheimer K.; Zhou L.; Birchmeier W.
E-Cadherin in human brain tumours: loss of immunoreactivity in malignant meningiomas
Virchows Archiv 432: 163-167 (1998-01-01)



Meiners S.; Brinkmann V.; Naundorf H.; Birchmeier W.
Role of morphogenetic factors in metastasis of mammary carcinoma cells
Oncogene 16: 9-20 (1998-01-01)



1997

Drab M.; Haller H.; Bychkov R.; Erdmann B.; Lindschau C.; Haase H.; Morano I.; Luft F.C.; Wobus A.M.
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model
FASEB Journal 11 (11): 905-915 (1997-09)



Schoenborn I.; Zschiesche W.; Behrens J.; Herrenknecht K.; Birchmeier W.
Expression of E-cadherin/catenin complexes in breast cancer: correlation with favourable prognostic factors and survival
International Journal of Oncology 11: 1327-1334 (1997-01-01)



Birchmeier W.; Brinkmann V.; Niemann C.; Meiners S.; Dicesare S.; Naundorf H.; Sachs M.
Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells
Ciba Foundation Symposia 212: 230-240 (1997-01-01)



Schaper F.; Siewert E.; Gomez-Lechon M.J.; Gatsios P.; Sachs M.; Birchmeier W.; Heinrich P.C.; Castell J.
Hepatocyte growth factor/ scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes
FEBS Letters 405: 99-103 (1997-01-01)



Zschiesche W.; Schoenborn I.; Behrens J.; Herrenknecht K.; Hartveit F.; Lilleng P.; Birchmeier W.
Expression of E-cadherin and catenins in invasive mammary carcinomas
Anticancer Research 17: 561-567 (1997-01-01)



Faraldo M.L.M.; Rodrigo I.; Behrens J.; Birchmeier W.; Cano A.
Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis
Molecular Carcinogenesis 20: 33-47 (1997-01-01)



1996

Weidner K.M.; Dicesare S.; Sachs M.; Brinkmann V.; Behrens J.; Birchmeier W.
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
Nature 384 (6605): 173-176 (1996-11-14)



Haller H.; Lindschau C.; Erdmann B.; Quass P.; Luft F.C.
Effects of intracellular angiotensin II in vascular smooth muscle cells
Circulation Research 79 (4): 765-772 (1996-10-01)



Ruiz P.; Brinkmann V.; Ledermann B.; Behrend M.; Grund C.; Thalhammer C.; Vogel F.; Birchmeier C.; Guenthert U.; Franke W.W.; Birchmeier W.
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
Journal of Cell Biology 135 (1): 215-225 (1996-10)



Behrens J.; von Kries J.P.; Kuehl M.; Bruhn L.; Wedlich D.; Grosschedl R.; Birchmeier W.
Functional interaction of beta-catenin with the transcription factor LEF-1
Nature 382 (6592): 638-642 (1996-08-15)



Sachs M.; Weidner K.M.; Brinkmann V.; Walther I.; Obermeier A.; Ullrich A.; Birchmeier W.
Motogenic and morphogenic activity of epithelial receptor tyrosine kinases
Journal of Cell Biology 133 (5): 1095-1107 (1996-06-03)



Birchmeier W.; Behrens J.; Weidner K.M.; Huelsken J.; Birchmeier C.
Epithelial differentiation and the control of metastasis in carcinomas
Current Topics in Microbiology and Immunology : 117-135 (1996-01-01)



Birchmeier C.; Birchmeier W.; Brand-Saberi B.
Epithelial-mesenchymal transitions in cancer progression
Acta Anatomica 156: 217-226 (1996-01-01)



Gabbert H.E.; Mueller W.; Schneiders A.; Meier S.; Moll R.; Birchmeier W.; Hommel G.
Prognostic value of E-cadherin expression in 413 gastric carcinomas
International Journal of Cancer 69: 184-189 (1996-01-01)



Erdmann B.; Fuxe K.; Ganten D.
Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex
Hypertension 28: 818-824 (1996-01-01)



Guenthert U.; Schlag P.M.; Birchmeier W.
Attempts to Understand Metastasis Formation I - III. Part 3: Therapeutic Approaches to Metastasis Treatment
: (1996-01-01)



Guenthert U.; Birchmeier W.
Attempts to Understand Metastasis Formation I - III. Part 1: Metastasis-Related Molecules
: (1996-01-01)



Erdmann B.; Gerst H.; Lippoldt A.; Buelow H.; Ganten D.; Fuxe K.; Bernhardt R.
Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats
Brain Research 733: 73-82 (1996-01-01)



Guenthert U.; Birchmeier W.
Attempts to Understand Metastasis Formation I - III. Part 2: Regulatory Factors
: (1996-01-01)



Hennig G.; Loewrick O.; Birchmeier W.; Behrens J.
Mechanisms identified in the transcriptional control of epithelial gene expression
Journal of Biological Chemistry 271: 595-602 (1996-01-01)



1995

Brinkmann V.; Foroutan H.; Sachs M.; Weidner K.M.; Birchmeier W.
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells
Journal of Cell Biology 131 (6 Pt. 1): 1573-1586 (1995-12)



Takeda H.; Nagafuchi A.; Yonemura S.; Tsukita S.; Behrens J.; Birchmeier W.; Tsukita S.
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift
Journal of Cell Biology 131 (6 Pt. 2): 1839-1847 (1995-12)



Yang Y.; Spitzer E.; Meyer D.; Sachs M.; Niemann C.; Hartmann G.; Weidner K.M.; Birchmeier C.; Birchmeier W.
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland
Journal of Cell Biology 131 (1): 215-226 (1995-10)



Hennig G.; Behrens J.; Truss M.; Frisch S.; Reichmann E.; Birchmeier W.
Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo
Oncogene 11: 475-484 (1995-01-01)



Birchmeier W.; Huelsken J.; Behrens J.
E-cadherin as an invasion suppressor
Ciba Foundation Symposia 189: 124-136, discussion 136-41, 174-6 (1995-01-01)



Birchmeier W.; Birchmeier C.
Epithelial-mesenchymal transitions in development and tumor progression
Epithelial-Mesenchymal Interactions in Cancer : 1-15 (1995-01-01)



Scheumman G.F.W.; Hoangvu C.; Cetin Y.; Gimm O.; Behrens J.; von Wasielewski R.; Georgii A.; Birchmeier W.; von zur Muehlen A.; Dralle H.; Brabant G.
Clinical significance of e-cadherin as a prognostic marker in thyroid carcinomas
Journal of Clinical Endocrinology and Metabolism 80 (7): 2168-2172 (1995-01-01)



Schlag P.M.; Huenerbein M.; Hohenberger P.
Surgical and multimodal approaches to liver metastases
Attempts to Understand Metastasis Formation : 241-256 (1995-01-01)



Birchmeier W.; Huelsken J.; Behrens J.
Adherens junction proteins in tumour progression
Cancer Surveys 24: 129-140 (1995-01-01)



Weidner K.M.; Sachs M.; Riethmacher D.; Birchmeier W.
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells
Proceedings of the National Academy of Sciences of the United States of America 92: 2597-2601 (1995-01-01)



Birchmeier W.
E-cadherin as a tumor (invasion) suppressor gene
BioEssays 17: 97-99 (1995-01-01)



Plaschke-Schluetter A.; Behrens J.; Gherardi E.; Birchmeier W.
Characterization of the scatter factor/hepatocyte growth factor gene promoter - positive and negative regulatory elements direct gene expression to mesenchymal cells
Journal of Biological Chemistry 270: 830-836 (1995-01-01)



Erdmann B.; Denner K.; Gerst H.; Lenz D.; Bernhardt R.
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures
Endocrine Research 21: 425-435 (1995-01-01)



Erdmann B.; Gerst H.; Buelow H.; Lenz D.; Baehr V.; Bernhardt R.
Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes
Histochemistry and Cell Biology 104: 301-307 (1995-01-01)



Spitzer E.; Zschiesche W.; Binas B.; Grosse R.; Erdmann B.
EGF and TGFalpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: Possible role of the arachidomic pathway
Journal of Cellular Biochemistry 57: 495-508 (1995-01-01)



1994

Huelsken J.; Birchmeier W.; Behrens J.
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
Journal of Cell Biology 127 (6 Pt. 2): 2061-2069 (1994-12)



Otto T.; Birchmeier W.; Schmidt U.; Hinke A.; Schipper J.; Ruebben H.; Raz A.
Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas
Cancer Research 54 (12): 3120-3123 (1994-06-15)



Birchmeier W.; Behrens J.
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness
Biochimica et Biophysica Acta 1198 (1): 11-26 (1994-05-27)



Oda T.; Kanai Y.; Oyama T.; Yoshiura K.; Shimoyama Y.; Birchmeier W.; Sugimura T.; Hirohashi S.
E-cadherin gene mutations in human gastric carcinoma cell lines
Proceedings of the National Academy of Sciences of the United States of America 91 (5): 1858-1862 (1994-03-01)



Hartmann G.; Weidner K.M.; Schwarz H.; Birchmeier W.
The motility signal of scatter factor /hepatocyte growth factor mediated through the receptor tyrosine kinase Met requires intracellular action of Ras
Journal of Biological Chemistry 269: 21936-21939 (1994-01-01)



Kraus C.; Liehr T.; Huelsken J.; Behrens J.; Birchmeier W.; Grzeschik K.H.; Ballhausen W.G.
Localization of the human beta-catenin gene (CTNNB1) to 3p21: A region implicated in tumor development
Genomics 23: 272-274 (1994-01-01)



Huelsken J.; Behrens J.; Birchmeier W.
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection
Current Opinion in Cell Biology 6: 711-716 (1994-01-01)



Behrens J.; Birchmeier W.
Cell-cell adhesion in invasion and metastasis of carcinomas
Mammary Tumorigenesis and Malignant Progression : 251-266 (1994-01-01)



Birchmeier W.
Molecular aspects of the loss of cell adhesion and gain of invasiveness in carcinomas
Proceedings of the international symposium of the Princess Takamatsu Cancer Research Fund : 214-232 (1994-01-01)



Erdmann B.; Henning M.; Uhlmann H.; Beckert V.; Grunau C.; Bernhardt R.
Immunocytochemical localization of heterologously expressed adrenodoxin and its electron acceptor cytochrome P45011B1 in Escherichia coli
European Journal of Cell Biology 65: 220-228 (1994-01-01)



Birchmeier W.; Birchmeier C.
Mesenchymal-epithelial transitions
BioEssays 16: 305-307 (1994-01-01)



Boehm M.; Totzeck B.; Birchmeier W.; Wieland I.
Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer
Clinical and Experimental Metastasis 12: 55-62 (1994-01-01)



Breter H.; Erdmann B.
Localization of mammary-derived growth inhibitor in capillary endothelial cells of the bovine mammary gland
Cell and Tissue Research 277: 457-464 (1994-01-01)



1993

Moll R.; Mitze M.; Frixen U.H.; Birchmeier W.
Differential loss of E-Cadherin expression in infiltrating ductal and lobular breast carcinomas
American Journal of Pathology 143 (6): 1731-1742 (1993-12-01)



Slagle B.L.; Zhou Y.Z.; Birchmeier W.; Scorsone K.A.
Deletion of the e-Cadherin gene in hepatitis-B virus-positive chinese hepatocellular carcinomas
Hepatology 18 (4): 757-762 (1993-10-01)



Birchmeier W.; Weidner K.M.; Huelsken J.; Behrens J.
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
Seminars in Cancer Biology 4 (4): 231-239 (1993-08-01)



Weidner K.M.; Sachs M.; Birchmeier W.
The Met receptor tyrosine kinase transduces motility, proliferation, andmorphogenic signals of scatter factor/ hepatocyte growth factor in epithelial cells
Journal of Cell Biology 121 (1): 145-154 (1993-04)



Mayer B.; Johnson J.P.; Leitl F.; Jauch K.W.; Heiss M.M.; Schildberg F.W.; Birchmeier W.; Funke I.
E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration
Cancer Research 53 (7): 1690-1695 (1993-04-01)



Behrens J.; Vakaet L.; Friis R.; Winterhager E.; van Roy F.; Mareel M.M.; Birchmeier W.
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/?catenin complex in cells transformed with a temperature-sensitive v-SRC gene
Journal of Cell Biology 120 (3): 757-766 (1993-02)



Birchmeier W.; Weidner K.M.; Behrens J.
Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells
Journal of Cell Science Suppl. 17: 159-164 (1993-01-01)



Breter H.; Erdmann B.
Suitability of different protein a-gold markers for immunogold- silver staining in paraffin sections
Biotechnic and Histochemistry 68: 206-210 (1993-01-01)



Weidner K.M.; Hartmann G.; Naldini L.; Comoglio P.M.; Sachs M.; Fonatsch C.; Rieder H.; Birchmeier W.
Molecular characteristics of HGF-SF and its role in cell motility and invasion
Hepatocyte Growth Factor (HGF-SF) and the C-Met Receptor : 311-328 (1993-01-01)



Birchmeier C.; Birchmeier W.
Molecular aspects of mesenchymal-epithelial interactions
Annual Review of Cell Biology 9: 511-540 (1993)



Birchmeier W.
Undercoat-constitutive proteins of cell-cell adherens junctions
Japanese Journal of Cancer Research 84: 1332-1333 (1993-01-01)



Weidner K.M.; Hartmann G.; Sachs M.; Birchmeier W.
Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met
American Journal of Respiratory Cell and Molecular Biology 8: 229-237 (1993-01-01)



Erdmann B.; Breter H.
Irregular distribution of mammary-derived growth inhibitor in the bovine mammary epithelium
Cell and Tissue Research 272: 383-389 (1993-01-01)



1992

Naldini L.; Tamagnone L.; Vigna E.; Sachs M.; Hartmann G.; Birchmeier W.; Daikuhara Y.; Tsubouchi H.; Blasi F.; Comoglio P.M.
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
EMBO Journal 11 (13): 4825-4833 (1992-12-01)



Binas B.; Spitzer E.; Zschiesche W.; Erdmann B.; Kurtz A.; Mueller T.; Niemann C.; Blenau W.; Grosse R.
Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants
In Vitro Cellular & Developmental Biology 28A (9-10): 625-634 (1992-09)



Behrens J.; Frixen U.; Schipper J.; Weidner K.M.; Birchmeier W.
Cell adhesion in invasion and metastasis
Seminars in Cell Biology 3: 169-178 (1992-01-01)



Birchmeier W.; Weidner K.M.; Behrens J.
Molecular aspects of the invasion of carcinoma cells
Metastasis : Basic Research and its Clinical Application : 95-107 (1992-01-01)



Hartmann G.; Naldini L.; Weidner K.M.; Sachs M.; Vigna E.; Comoglio P.M.; Birchmeier W.
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis
Proceedings of the National Academy of Sciences of the United States of America 89: 11574-11578 (1992-01-01)