Publications



2017

Schuetz A.; Radusheva V.; Krug S.M.; Heinemann U.
Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Annals of the New York Academy of Sciences 1405 (1): 147-159 (2017-10)



Consentius P.; Gohlke U.; Loll B.; Alings C.; Heinemann U.; Wahl M.C.; Risse T.
Combining EPR spectroscopy and X-ray crystallography to elucidate the structure and dynamics of conformationally constrained spin labels in T4 lysozyme single crystals
Physical Chemistry Chemical Physics 19 (31): 20723-20734 (2017-08-09)



Carter D.M.; Specker E.; Przygodda J.; Neuenschwander M.; von Kries J.P.; Heinemann U.; Nazare M.; Gohlke U.
Identification of a novel benzimidazole pyrazolone scaffold that inhibits KDM4 lysine demethylases and reduces proliferation of prostate cancer cells
SLAS Discovery 22 (7): 801-812 (2017-08)



Jennek S.; Mittag S.; Reiche J.; Westphal J.K.; Seelk S.; Doerfel M.J.; Pfirrmann T.; Friedrich K.; Schuetz A.; Heinemann U.; Huber O.
Tricellulin is a target of the ubiquitin ligase Itch
Annals of the New York Academy of Sciences 1397 (1): 157-168 (2017-06)



Consentius P.; Loll B.; Gohlke U.; Alings C.; Mueller C.; Mueller R.; Teutloff C.; Heinemann U.; Kaupp M.; Wahl M.C.; Risse T.
Internal dynamics of the 3-pyrroline-N-oxide ring in spin-labeled proteins
Journal of Physical Chemistry Letters 8 (6): 1113-1117 (2017-03-16)



2016

Arumughan A.; Roske Y.; Barth C.; Lleras Forero L.; Bravo-Rodriguez K.; Redel Al.; Kostova S.; McShane E.; Opitz R.; Faelber K.; Rau K.; Mielke T.; Daumke O.; Selbach M.; Sanchez-Garcia E.; Rocks O.; Panakova D.; Heinemann U.; Wanker E.E.
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers
Nature Communications 7: 13047 (2016-10-20)



Consentius P.; Gohlke U.; Loll B.; Alings C.; Mueller R.; Heinemann U.; Kaupp M.; Wahl M.; Risse T.
Tracking transient conformational states of T4 lysozyme at room temperature combining X-ray crystallography and site-directed spin labeling
Journal of the American Chemical Society 138 (39): 12868-12875 (2016-10-05)



Kang Y.; Gohlke U.; Engstroem O.; Hamark C.; Scheidt T.; Kunstmann S.; Heinemann U.; Widmalm G.; Santer M.; Barbirz S.
Bacteriophage tailspikes and bacterial O-antigens as a model system to study weak-affinity protein-polysaccharide interactions
Journal of the American Chemical Society 138 (29): 9109-9118 (2016-07-27)



Kowenz-Leutz E.; Schuetz A.; Liu Q.; Knoblich M.; Heinemann U.; Leutz A.
Functional interaction of CCAAT/enhancer-binding-protein-{alpha} basic region mutants with E2F transcription factors and DNA
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1859 (7): 841-847 (2016-07)



Goetz F.; Roske Y.; Schulz M.S.; Autenrieth K.; Bertinetti D.; Faelber K.; Zuehlke K.; Kreuchwig A.; Kennedy E.; Krause G.; Daumke O.; Herberg F.W.; Heinemann U.; Klussmann E.
AKAP18:PKA-RII{alpha} structure reveals crucial anchor points for recognition of regulatory subunits of PKA
Biochemical Journal 473 (13): 1881-1894 (2016-06-28)



Sparta K.M.; Krug M.; Heinemann U.; Mueller U.; Weiss M.S.
XDSAPP2.0
Journal of Applied Crystallography 49 (3): 1085-1092 (2016-06)



2015

Murakawa Y.; Hinz M.; Mothes J.; Schuetz A.; Uhl M.; Wyler E.; Yasuda T.; Mastrobuoni G.; Friedel C.C.; Doelken L.; Kempa S.; Schmidt-Supprian M.; Bluethgen N.; Backofen R.; Heinemann U.; Wolf J.; Scheidereit C.; Landthaler M.
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-{kappa}B pathway
Nature Communications 6: 7367 (2015-07-14)



Wagner S.; Schuetz A.; Rademann J.
Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic
Bioorganic and Medicinal Chemistry 23 (12): 2839-2847 (2015-06-15)



Grosskopf S.; Eckert C.; Arkona C.; Radetzki S.; Boehm K.; Heinemann U.; Wolber G.; von Kries J.P.; Birchmeier W.; Rademann J.
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo
ChemMedChem 10 (5): 815-826 (2015-05)



Opitz R.; Mueller M.; Reuter C.; Barone M.; Soicke A.; Roske Y.; Piotukh K.; Huy P.; Beerbaum M.; Wiesner B.; Beyermann M.; Schmieder P.; Freund C.; Volkmer R.; Oschkinat H.; Schmalz H.G.; Kuehne R.
A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions
Proceedings of the National Academy of Sciences of the United States of America 112 (16): 5011-5016 (2015-04-21)



2014

Schuetz A.; Murakawa Y.; Rosenbaum E.; Landthaler M.; Heinemann U.
Roquin binding to target mRNAs involves a winged helix-turn-helix motif
Nature Communications 5: 5701 (2014-12-11)



Behrmann H.; Luerick A.; Kuhlee A.; Kleine Balderhaar H.; Broecker C.; Kuemmel D.; Engelbrecht-Vandre S.; Gohlke U.; Raunser S.; Heinemann U.; Ungermann C.
Structural identification of the VPS18 {beta}-propeller reveals a critical role in the HOPS complex stability and function
Journal of Biological Chemistry 289 (48): 33503-33512 (2014-11-28)



Wang C.; Gohlke U.; Roske Y.; Heinemann U.
Crystal structure of the yeast TRAPP-associated protein Tca17
FEBS Journal 281 (18): 4195-4206 (2014-09)



Seul A.; Mueller J.J.; Andres D.; Stettner E.; Heinemann U.; Seckler R.
Bacteriophage P22 tailspike: structure of the complete protein and function of the interdomain linker
Acta Crystallographica Section D 70 (Pt 5): 1336-1345 (2014-05)



2013

Kheirabadi M.; Sharafian Z.; Naderi-Manesh H.; Heinemann U.; Gohlke U.; Hosseinkhani S.
Crystal structure of native and a mutant of Lampyris turkestanicus luciferase implicate in bioluminescence color shift
Biochimica et Biophysica Acta - Proteins and Proteomics 1834 (12): 2729-2735 (2013-10-06)



Mayr F.; Heinemann U.
Mechanisms of Lin28-mediated miRNA and mRNA regulation : a structural and functional perspective
International Journal of Molecular Sciences 14 (8): 16532-16553 (2013-08-09)



Graf R.; Munschauer M.; Mastrobuoni G.; Mayr F.; Heinemann U.; Kempa S.; Rajewsky N.; Landthaler M.
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
RNA Biology 10 (7): 1146-1159 (2013-07-01)



Andres D.; Gohlke U.; Broeker N.K.; Schulze S.; Rabsch W.; Heinemann U.; Barbirz S.; Seckler R.
An essential serotype recognition pocket on phage P22 tailspike protein forces Salmonella enterica serovar Paratyphi A O-antigen fragments to bind as nonsolution conformers
Glycobiology 23 (4): 486-494 (2013-04)



Broeker N.K.; Gohlke U.; Mueller J.J.; Uetrecht C.; Heinemann U.; Seckler R.; Barbirz S.
Single amino acid exchange in bacteriophage HK620 tailspike protein results in thousand-fold increase of its oligosaccharide affinity
Glycobiology 23 (1): 59-68 (2013-01)



2012

Schlundt A.; Guenther S.; Sticht J.; Wieczorek M.; Roske Y.; Heinemann U.; Freund C.
Peptide linkage to the {alpha}-subunit of MHCII creates a stably inverted antigen presentation complex
Journal of Molecular Biology 423 (3): 294-302 (2012-10-26)



Horatscheck A.; Wagner S.; Ortwein J.; Kim B.G.; Lisurek M.; Beligny S.; Schuetz A.; Rademann J.
Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains
Angewandte Chemie International Edition 51 (37): 9441-9447 (2012-09-10)



Kirchner F.; Schuetz A.; Boldt L.H.; Martens K.; Dittmar G.; Haverkamp W.; Thierfelder L.; Heinemann U.; Gerull B.
Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations
Circulation Cardiovascular Genetics 5 (4): 400-411 (2012-08-01)



Mayr F.; Schuetz A.; Doege N.; Heinemann U.
The Lin28 cold-shock domain remodels pre-let-7 microRNA
Nucleic Acids Research 40 (15): 7492-7506 (2012-08-01)



Krug M.; Weiss M.S.; Heinemann U.; Mueller U.
XDSAPP: a graphical user interface for the convenient processing of diffraction data using XDS
Journal of Applied Crystallography 45 (3): 568-572 (2012-06)



Hanna J.; Schuetz A.; Zimmermann F.; Behlke J.; Sommer T.; Heinemann U.
Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex
Journal of Biological Chemistry 287 (11): 8633-8640 (2012-03-09)



Andresen D.; Roske Y.; Doering C.; Heinemann U.; Seckler R.; Barbirz S.
Tail morphology controls DNA release in two Salmonella phages with one lipopolysaccharide receptor recognition system
Molecular Microbiology 83 (6): 1244-1253 (2012-03)



Volz T.; Luetgehetmann M.; Allweiss L.; Warlich M.; Bierwolf J.; Pollok J.M.; Petersen J.; Matthes E.; Dandri M.
Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice
Antiviral Therapy 17 (4): 623-631 (2012-02-27)



von Eyss B.; Maaskola J.; Memczak S.; Moellmann K.; Schuetz A.; Loddenkemper C.; Tanh M.D.; Otto A.; Muegge K.; Heinemann U.; Rajewsky N.; Ziebold U.
The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation
EMBO Journal 31 (4): 972-985 (2012-02-15)



Sachs R.; Max K.E.; Heinemann U.; Balbach J.
RNA single strands bind to a conserved surface of the major cold shock protein in crystals and solution
RNA 18 (1): 65-76 (2012-01)



2011

Mueller J.J.; Weiss M.S.; Heinemann U.
PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 {angstrom} resolution and its complex with 1-thio-{beta}-D-galactose
Acta Crystallographica Section D 67 (Pt 11): 936-944 (2011-11)



Faelber K.; Posor Y.; Gao S.; Held M.; Roske Y.; Schulze D.; Haucke V.; Noe F.; Daumke O.
Crystal structure of nucleotide-free dynamin
Nature 477 (7366): 556-560 (2011-09-29)



Schuetz A.; Nana D.; Rose C.; Zocher G.; Milanovic M.; Koenigsmann J.; Blasig R.; Heinemann U.; Carstanjen D.
The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation
Cellular and Molecular Life Sciences 68 (18): 3121-3131 (2011-09)



Saupe J.; Roske Y.; Schillinger C.; Kamdem N.; Radetzki S.; Diehl A.; Oschkinat H.; Krause G.; Heinemann U.; Rademann J.
Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain
ChemMedChem 6 (8): 1411-1422 (2011-08-01)



Busso D.; Peleg Y.; Heidebrecht T.; Romier C.; Jacobovitch Y.; Dantes A.; Salim L.; Troesch E.; Schuetz A.; Heinemann U.; Folkers G.E.; Geerlof A.; Wilmanns M.; Polewacz A.; Quedenau C.; Buessow K.; Adamson R.; Blagova E.; Walton J.; Cartwright J.L.; Bird L.E.; Owens R.J.; Berrow N.S.; Wilson K.S.; Sussman J.L.; Perrakis A.; Celie P.H.
Expression of protein complexes using multiple E. coli protein co-expression systems: a benchmarking study
Journal of Structural Biology 175 (2): 159-170 (2011-08)



Mueller J.J.; Hannemann F.; Schiffler B.; Ewen K.M.; Kappl R.; Heinemann U.; Bernhardt R.
Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe
Journal of Inorganic Biochemistry 105 (7): 957-965 (2011-07)



2010

Guenther S.; Schlundt A.; Sticht J.; Roske Y.; Heinemann U.; Wiesmueller K.H.; Jung G.; Falk K.; Roetzschke O.; Freund C.
Bidirectional binding of invariant chain peptides to an MHC class II molecule
Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22219-22224 (2010-12-21)



Ash M.R.; Faelber K.; Kosslick D.; Albert G.I.; Roske Y.; Kofler M.; Schuemann M.; Krause E.; Freund C.
Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes
Structure 18 (8): 944-954 (2010-08-11)



Kuemmel D.; Walter J.; Heck M.; Heinemann U.; Veit M.
Characterization of the self-palmitoylation activity of the transport protein particle component Bet3
Cellular and Molecular Life Sciences 67 (15): 2653-2664 (2010-08)



Zaragoza K.; Begay V.; Schuetz A.; Heinemann U.; Leutz A.
Repression of transcriptional activity of C/EBP{alpha} by E2F-DP complexes
Molecular and Cellular Biology 30 (9): 2293-2304 (2010-05)



Boehm K.; Herter T.; Mueller J.J.; Borriss R.; Heinemann U.
Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme
FEBS Journal 277 (5): 1284-1296 (2010-03)



Lange V.; Becker-Baldus J.; Kunert B.; van Rossum B.J.; Casagrande F.; Engel A.; Roske Y.; Scheffel F.M.; Schneider E.; Oschkinat H.
A MAS NMR study of the bacterial ABC transporter ArtMP
Chembiochem 11 (4): 547-555 (2010-03-01)



Patzke C.; Max K.E.; Behlke J.; Schreiber J.; Schmidt H.; Dorner A.A.; Kroeger S.; Henning M.; Otto A.; Heinemann U.; Rathjen F.G.
The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells
Journal of Neuroscience 30 (8): 2897-2910 (2010-02-24)



Striegl H.; Andrade-Navarro M.A.; Heinemann U.
Armadillo motifs involved in vesicular transport
PLoS ONE 5 (2): e8991 (2010-02-01)



2009

Horn S.C.; Hanna J.; Hirsch C.; Volkwein C.; Schuetz A.; Heinemann U.; Sommer T.; Jarosch E.
Usa1 functions as a scaffold of the HRD-ubiquitin ligase
Molecular Cell 36 (5): 782-793 (2009-12-11)



Thoms S.; Max K.E.; Wunderlich M.; Jacso T.; Lilie H.; Reif B.; Heinemann U.; Schmid F.X.
Dimer formation of a stabilized Gbeta1 variant. A structural and energetic analysis
Journal of Molecular Biology 391 (5): 918-932 (2009-09-04)



Hannemann F.; Guyot A.; Zoellner A.; Mueller J.J.; Heinemann U.; Bernhardt R.
The dipole moment of the electron carrier adrenodoxin is not critical for redox partner interaction and electron transfer
Journal of Inorganic Biochemistry 103 (7): 997-1004 (2009-07)



Kumar V.; Roske Y.; Singh N.; Heinemann U.; Singh T.P.; Yadav S.
Purification and preliminary X-ray crystallographic studies of beta-microseminoprotein from human seminal plasma
Acta Crystallographica Section F 65 (5): 518-521 (2009-05-01)



Koenig B.; Mueller J.J.; Lanka E.; Heinemann U.
Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation
Nucleic Acids Research 37 (6): 1915-1924 (2009-04)



Striegl H.; Roske Y.; Kuemmel D.; Heinemann U.
Unusual armadillo fold in the human general vesicular transport factor p115
PLoS ONE 4 (2): e4656 (2009-02-27)



Guenther U.P.; Handoko L.; Varon R.; Stephani U.; Tsao C.Y.; Mendell J.R.; Luetzkendorf S.; Huebner C.; von Au K.; Jablonka S.; Dittmar G.; Heinemann U.; Schuetz A.; Schuelke M.
Clinical variability in distal spinal muscular atrophy type 1 (DSMA1): determination of steady-state IGHMBP2 protein levels in five patients with infantile and juvenile disease
Journal of Molecular Medicine 87 (1): 31-41 (2009-01)



2008

Kuemmel D.; Oeckinghaus A.; Wang C.; Krappmann D.; Heinemann U.
Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells
FEBS Letters 582 (27): 3729-3733 (2008-11-12)



Schulze J.O.; Quedenau C.; Roske Y.; Adam T.; Schueler H.; Behlke J.; Turnbull A.P.; Sievert V.; Scheich C.; Mueller U.; Heinemann U.; Buessow K.
Structural and functional characterization of human Iba proteins
FEBS Journal 275 (18): 4627-4640 (2008-09)



Barbirz S.; Mueller J.J.; Uetrecht C.; Clark A.J.; Heinemann U.; Seckler R.
Crystal structure of Escherichia coli phage HK620 tailspike: podoviral tailspike endoglycosidase modules are evolutionarily related
Molecular Microbiology 69 (2): 303-316 (2008-07)



Niesen F.H.; Koch A.; Lenski U.; Harttig U.; Roske Y.; Heinemann U.; Hofmann K.P.
An approach to quality management in structural biology: Biophysical selection of proteins for successful crystallization
Journal of Structural Biology 162 (3): 451-459 (2008-06)



Mueller J.J.; Barbirz S.; Heinle K.; Freiberg A.; Seckler R.; Heinemann U.
An intersubunit active site between supercoiled parallel beta helices in the trimeric tailspike endorhamnosidase of Shigella flexneri phage Sf6
Structure 16 (5): 766-775 (2008-05-07)



Kuemmel D.; Heinemann U.
Diversity in structure and function of tethering complexes: Evidence for different mechanisms in vesicular transport regulation
Current Protein & Peptide Science 9 (2): 197-209 (2008-04)



Graeslund S.; Nordlund P.; Weigelt J.; Hallberg M.; Bray J.; Gileadi O.; Knapp S.; Oppermann U.; Arrowsmith C.; Hui R.; Ming J.; dhe-Paganon S.; Park H.W.; Savchenko A.; Yee A.; Edwards A.; Vincentelli R.; Cambillau C.; Kim R.; Kim S.H.; Rao Z.; Shi Y.; Terwilliger T.C.; Kim C.Y.; Hung L.W.; Waldo G.S.; Peleg Y.; Albeck S.; Unger T.; Dym O.; Prilusky J.; Sussman J.L.; Stevens R.C.; Lesley S.A.; Wilson I.A.; Joachimiak A.; Collart F.; Dementieva I.; Donnelly M.I.; Eschenfeldt W.H.; Kim Y.M.; Stols L.; Wu R.; Zhou M.; Burley S.K.; Emtage J.S.; Sauder J.M.; Thompson D.; Bain K.; Luz J.; Gheyi T.; Zhang F.; Atwell S.; Almo S.C.; Bonanno J.B.; Fiser A.; Swaminathan S.; Studier F.W.; Chance M.R.; Sali A.; Acton T.B.; Xiao R.; Zhao L.; Ma L.C.; Hunt J.F.; Tong L.; Cunningham K.; Inouye M.; Anderson S.; Janjua H.; Shastry R.; Ho C.K.; Wang D.; Wang H.; Jiang M.; Montelione G.T.; Stuart D.I.; Owens R.J.; Daenke S.; Schuetz A.; Heinemann U.; Yokoyama S.; Buessow K.; Gunsalus K.C.
Protein production and purification
Nature Methods 5 (2): 135-146 (2008-02)



2007

Banci L.; Baumeister W.; Heinemann U.; Schneider G.; Silman I.; Stuart D.I.; Sussman J.L.
An idea whose time has come
Genome Biology 8 (11): 408 (2007-11-07)



Wunderlich M.; Max K.E.; Roske Y.; Mueller U.; Heinemann U.; Schmid F.X.
Optimization of the Gbeta1 domain by computational design and by in vitro evolution: structural and energetic basis of stabilization
Journal of Molecular Biology 373 (3): 775-784 (2007-10-26)



Max K.E.; Wunderlich M.; Roske Y.; Schmid F.X.; Heinemann U.
Optimized Variants of the Cold Shock Protein from in Vitro Selection: Structural Basis of Their High Thermostability
Journal of Molecular Biology 369 (4): 1087-1097 (2007-06-15)



Morgan H.P.; Estibeiro P.; Wear M.A.; Max K.E.; Heinemann U.; Cubeddu L.; Gallagher M.P.; Sadler P.J.; Walkinshaw M.D.
Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach
Nucleic Acids Research 35 (10): e75 (2007-05)



Scheich C.; Kuemmel D.; Soumailakakis D.; Heinemann U.; Buessow K.
Vectors for co-expression of an unrestricted number of proteins
Nucleic Acids Research 35 (6): e43 (2007-03)



Max K.E.; Zeeb M.; Bienert R.; Balbach J.; Heinemann U.
Common mode of DNA binding to cold shock domains: Crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus
FEBS Journal 274 (5): 1265-1279 (2007-03)



Banci L.; Baumeister W.; Enfedaque J.; Heinemann U.; Schneider G.; Silman I.; Sussman J.L.
Structural proteomics: from the molecule to the system
Nature Structural & Molecular Biology 14 (1): 3-4 (2007-01)



2006

Aricescu A.R.; Assenberg R.; Bill R.M.; Busso D.; Chang V.T.; Davis S.J.; Dubrovsky A.; Gustafsson L.; Hedfalk K.; Heinemann U.; Jones I.M.; Ksiazek D.; Lang C.; Maskos K.; Messerschmidt A.; Macieira S.; Peleg Y.; Perrakis A.; Poterszman A.; Schneider G.; Sixma T.K.; Sussman J.L.; Sutton G.; Tarboureich N.; Zeev-Ben-Mordehai T.; Jones E.Y.
Eukaryotic expression: developments for structural proteomics
Acta Crystallographica Section D 62 (Pt. 10): 1114-1124 (2006-10)



Banci L.; Bertini I.; Cusack S.; de Jong R.N.; Heinemann U.; Jones E.Y.; Kozielski F.; Maskos K.; Messerschmidt A.; Owens R.; Perrakis A.; Poterszman A.; Schneider G.; Siebold C.; Silman I.; Sixma T.; Stewart-Jones G.; Sussman J.L.; Thierry J.C.; Moras D.
First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value
Acta Crystallographica Section D 62 (Pt. 10): 1208-1217 (2006-10)



Hofmann K.P.; Spahn C.M.T.; Heinrich R.; Heinemann U.
Building functional modules from molecular interactions
Trends in Biochemical Sciences 31 (9): 497-508 (2006-09)



Kuemmel D.; Heinemann U.; Veit M.
Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability
Proceedings of the National Academy of Sciences of the United States of America 103 (34): 12701-12706 (2006-08-22)



Kuemmel D.; Mueller J.J.; Roske Y.; Henke N.; Heinemann U.
Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2
Journal of Molecular Biology 361 (1): 22-32 (2006-08-04)



Max K.E.A.; Zeeb M.; Bienert R.; Balbach J.; Heinemann U.
T-rich DNA single strands bind to a preformed site on the bacterial cold shock protein Bs-CspB
Journal of Molecular Biology 360 (3): 702-714 (2006-07-14)



Frese S.; Schubert W.D.; Findeis A.C.; Marquardt T.; Roske Y.S.; Stradal T.E.; Heinz D.W.
The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains
Journal of Biological Chemistry 281 (26): 18236-18245 (2006-06-30)



Mueller J.J.; Lunina N.L.; Urzhumtsev A.; Weckert E.; Heinemann U.; Lunin V.Y.
Low-resolution ab initio phasing of Sarcocystis muris lectin SML-2
Acta Crystallographica Section D 62 (Pt 5): 533-540 (2006-05)



Gaiser O.J.; Piotukh K.; Ponnuswamy W.N.; Planas A.; Borriss R.; Heinemann U.
Structural basis for the substrate specificity of a Bacillus 1,3-1,4-beta-glucanase
Journal of Molecular Biology 357 (4): 1211-1225 (2006-04-07)



Manjasetty B.A.; Buessow K.; Fieber-Erdmann M.; Roske Y.; Gobom J.; Scheich C.; Goetz F.; Niesen F.H.; Heinemann U.
Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold
Protein Science 15 (4): 914-920 (2006-04-01)



Bienert R.; Baier K.; Volkmer R.; Lockau W.; Heinemann U.
Crystal structure of NblA from Anabaena sp. PCC 7120, a small protein playing a key role in phycobilisome degradation
Journal of Biological Chemistry 281 (8): 5216-5223 (2006-02-24)



Halavaty A.; Mueller J.J.; Contzen J.; Jung C.; Hannemann F.; Bernhardt R.; Galander M.; Lendzian F.; Heinemann U.
Light-induced reduction of bovine adrenodoxin via the covalently bound ruthenium(II) bipyridyl complex: Intramolecular electron transfer and crystal structure
Biochemistry 45 (3): 709-718 (2006-01-24)



Heinemann U.
Structural genomics: structure-to-function approaches
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1810-1816 (2006)



Mueller J.J.; Heinemann U.
MAD phasing
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2 : 1002-1008 (2006)



Muntean C.M.; Misselwitz R.; Dostal L.; Welfle H.
Mn2+-DNA interactions in aqueous systems: A Raman spectroscopic study
Spectroscopy 20 (1): 29-35 (2006-01)



Kuemmel D.; Turnbull A.P.; Mueller J.J.; Roske Y.; Heinemann U.
Structural studies of the human tethering complex TRAPP involved in vesicular transport
: 80-84 (2006)



Zeeb M.; Max K.E.A.; Weininger U.; Loew C.; Sticht H.; Balbach J.
Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution
Nucleic Acids Research 34 (16): 4561-4571 (2006)



2005

Manjasetty B.A.; Niesen F.H.; Scheich C.; Roske Y.; Goetz F.; Behlke J.; Sievert V.; Heinemann U.; Buessow K.
X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1)
BMC Structural Biology 5 (14): 21 (2005-12-14)



Heinz A.; Hannemann F.; Mueller J.J.; Heinemann U.; Bernhardt R.
The interaction domain of the redox protein adrenodoxin is mandatory for binding of the electron acceptor CYP11A1, but is not required for binding of the electron donor adrenodoxin reductase
Biochemical and Biophysical Research Communications 338 (9): 491-498 (2005-08-29)



Kuemmel D.; Mueller J.J.; Roske Y.; Misselwitz R.; Buessow K.; Heinemann U.
The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex
EMBO Reports 6 (8): 787-793 (2005-08-06)



Buessow K.; Scheich C.; Sievert V.; Harttig U.; Schultz J.; Simon B.; Bork P.; Lehrach H.; Heinemann U.
Structural genomics of human proteins - target selection and generation of a public catalog of expression clones
Microbial Cell Factories 4: 21 (2005-07-05)



Turnbull A.P.; Kuemmel D.; Prinz B.; Holz C.; Schultchen J.; Lang C.; Niesen F.H.; Hofmann K.P.; Delbrueck H.; Behlke J.; Mueller E.C.; Jarosch E.; Sommer T.; Heinemann U.
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization
EMBO Journal 24 (5): 875-884 (2005-01-01)



Chevelkov V.; Faelber K.; Diehl A.; Heinemann U.; Oschkinat H.; Reif B.
Detection of dynamic water molecules in a microcrystalline sample of the SH3 domain of alpha-spectrin by MAS solid-state NMR
Journal of Biomolecular NMR 31 (4): 295-310 (2005-01-01)



2004

Roske Y.; Sunna A.; Pfeil W.; Heinemann U.
High-resolution crystal structures of Caldicellulosiruptor strain Rt8B.4 carbohydrate-binding module CBM27-1 and its complex with mannohexaose
Journal of Molecular Biology 340 (3): 543-554 (2004-07-09)



Manjasetty B.A.; Quedenau C.; Sievert V.; Buessow K.; Niesen F.; Delbrueck H.; Heinemann U.
X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma
Proteins: Structure, Function, and Bioinformatics 55 (1): 214-217 (2004-04)



Manjasetty B.A.; Delbrueck H.; Pham D.T.; Mueller U.; Fieber-Erdmann M.; Scheich C.; Sievert V.; Buessow K.; Niesen F.H.; Weihofen W.; Loll B.; Saenger W.; Heinemann U.
Crystal structure of Homo sapiens protein hp14.5
Proteins: Structure, Function, and Bioinformatics 54 (3): 797-800 (2004-03-01)



Khare D.; Ziegelin G.; Lanka E.; Heinemann U.
Sequence-specific DNA binding determined by contacts outside the helix-turn-helix motif of the ParB homolog KorB
Nature Structural & Molecular Biology 11 (7): 656-663 (2004-01-01)



Manjasetty B.A.; Niesen F.H.; Delbrueck H.; Goetz F.; Sievert V.; Buessow K.; Behlke J.; Heinemann U.
X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880
Biological Chemistry 385 (10): 935-942 (2004-01-01)



Gaiser O.J.; Oschkinat H.; Heinemann U.; Ball L.J.
1H, 13C and 15N resonance assignments of the C-terminal BRCT domain from human BRCA1
Journal of Biomolecular NMR 30 (2): 221-222 (2004-01-01)



Gaiser O.J.; Ball L.J.; Schmieder P.; Leitner D.; Strauss H.; Wahl M.; Kuehne R.; Oschkinat H.; Heinemann U.
Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1
Biochemistry 43 (51): 15983-15995 (2004-01-01)



Bienert R.; Zeeb M.; Dostal L.; Feske A.; Magg C.; Max K.; Welfle H.; Balbach J.; Heinemann U.
Single-stranded DNA bound to bacterial cold-shock proteins: preliminary crystallographic and Raman analysis
Acta Crystallographica Section D 60 (4): 755-757 (2004-01-01)



Manjasetty B.A.; Hennecke J.; Glockshuber R.; Heinemann U.
Structure of circularly permuted DsbAQ100T99: preserved global fold and local structural adjustments
Acta Crystallographica Section D 60 (2): 304-309 (2004-01-01)



2003

Mueller U.; Buessow K.; Diehl A.; Bartl F.J.; Niesen F.H.; Nyarsik L.; Heinemann U.
Rapid purification and crystal structure analysis of a small protein carrying two terminal affinity tags
Journal of Structural and Functional Genomics 4 (4): 217-225 (2003-12)



Zayed H.; Izsvak Z.; Khare D.; Heinemann U.; Ivics Z.
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition
Nucleic Acids Research 31 (9): 2313-2322 (2003-05-01)



Heinemann U.; Buessow K.; Mueller U.; Umbach P.
Facilities and methods for the high-throughput crystal structural analysis of human proteins
Accounts of Chemical Research 36 (3): 157-163 (2003-03)



Muller Y.A.; Heinemann U.
Molekuelmodelle und Modellmolekuele: Strukturanalyse grosser biologischer Molekuele fuer die Medizin
Grundlagen der Molekularen Medizin : 340-359 (2003-01-01)



Manjasetty B.A.; Hoppner K.; Mueller U.; Heinemann U.
Secure web book to store structural genomics research data
Journal of Structural and Functional Genomics 4 (2-3): 121-127 (2003-01-01)



Muller Y.A.; Heinemann U.
Molekuelmodelle und Modellmolekuele: Strukturanalyse grosser biologischer Molekuele fuer die Medizin
Handbuch der molekularen Medizin, Band 1, Molekular- und zellbiologische Grundlagen : 340-359 (2003)



Dostal L.; Khare D.; Bok J.; Heinemann U.; Lanka E.; Welfle H.
RP4 repressor protein KorB binds to the major groove of the operator DNA: A Raman study
Biochemistry 42 (49): 14476-14482 (2003-01-01)



2002

Mueller J.J.; Lapko A.; Ruckpaul K.; Heinemann U.
Modeling of electrostatic recognition processes in the mammalian mitochondrial steroid hydroxylase system
Biophysical Chemistry 100 (1-3): 281-292 (2002-12)



Avvakumov G.V.; Grishkovskaya I.; Muller Y.A.; Hammond G.L.
Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol
Journal of Biological Chemistry 277 (47): 45219-45225 (2002-11-22)



Muller Y.A.; Heiring C.; Misselwitz R.; Welfle K.; Welfle H.
The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
Journal of Biological Chemistry 277 (45): 43410-43416 (2002-11-08)



Heinemann U.
Establishing a structural genomics platform: The Berlin-based Protein Structure Factory
Gene Function and Disease 3 (1-2): 25-32 (2002-10)



Werner E.; Wende W.; Pingoud A.; Heinemann U.
High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI
Nucleic Acids Research 30 (18): 3962-3971 (2002-09-15)



Izsvak Z.; Khare D.; Behlke J.; Heinemann U.; Plasterk R.H.; Ivics Z.
Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition
Journal of Biological Chemistry 277 (37): 34581-34588 (2002-09-13)



Grishkovskaya I.; Avvakumov G.V.; Hammond G.L.; Catalano M.G.; Muller Y.A.
Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation
Journal of Biological Chemistry 277 (35): 32086-32093 (2002-08-30)



Grishkovskaya I.; Avvakumov G.V.; Hammond G.L.; Muller Y.A.
Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site
Journal of Molecular Biology 318 (3): 621-626 (2002-05-03)



Werner E.; Ziegler M.; Lerner F.; Schweiger M.; Heinemann U.
Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN
FEBS Letters 516 (1-3): 239-244 (2002-04-10)



Mueller J.J.; Mueller E.C.; Otto A.; Ruckpaul K.; Heineman U.; Lapko A.
Structure and recognition of components of the mitochondrial steroid hydroxylating system in adrenal cortex of vertebrates
Flavins and Flavoproteins 2002. Proceedings of the Fourteenth International Symposium : 491-499 (2002-01-01)



Delbrueck H.; Ziegelin G.; Lanka E.; Heinemann U.
An Src homology 3-like domain is responsible for dimerization of the repressor protein KorB encoded by the promiscuous IncP plasmid RP4
Journal of Biological Chemistry 277 (6): 4191-4198 (2002-01-01)



Werner E.; Ziegler M.; Lerner F.; Schweiger M.; Muller Y.A.; Heinemann U.
Crystallization and preliminary X-ray analysis of human nicotinamide mononucleotide adenylyltransferase (NMNAT)
Acta Crystallographica Section D 58 (1): 140-142 (2002-01-01)



Heinemann U.; Mueller J.J.; Polyakov K.M.
Structure of ribonucleases
Landolt-Boernstein, New Series: Numerical data...; Gr.7: Biophysics; Vol.2: Proteins; Subvol.A: Structural and physical data I : (2002-01-01)



2001

Olson W.K.; Bansal M.; Burley S.K.; Dickerson R.E.; Gerstein M.; Harvey S.C.; Heinemann U.; Lu X.J.; Neidle S.; Shakked Z.; Sklenar H.; Suzuki M.; Tung C.S.; Westhof E.; Wolberger C.; Berman H.M.
A standard reference frame for the description of nucleic acid base-pair geometry
Journal of Molecular Biology 313: 229-237 (2001-10-12)



Villoutreix B.O.; Dahlback B.; Borgel D.; Gandrille S.; Muller Y.A.
Three-dimensional model of the SHBG-like region of anticoagulant protein S: new structure-function insights
Proteins: Structure, Function, and Bioinformatics 43: 203-216 (2001-05-01)



Delbrueck H.; Mueller U.; Perl D.; Schmid F.X.; Heinemann U.
Crystal structures of mutant forms of the Bacillus caldolyticus cold shock protein differing in thermal stability
Journal of Molecular Biology 313 (2): 359-369 (2001-01-01)



Heinemann U.
The Berlin "protein structure factory" initiative: a technology-oriented approach to structural genomics
Ernst Schering Research Foundation Workshop 34: 101-121 (2001)



Mueller E.C.; Lapko A.; Otto A.; Mueller J.J.; Ruckpaul K.; Heinemann U.
Covalently crosslinked complexes of bovine adrenodoxin with adrenodoxin reductase and cytochrome P450scc. Mass spectrometry and Edman degradation of complexes of the steroidogenic hydroxylase system.
European Journal of Biochemistry 268 (6): 1837-1843 (2001-01-01)



Faelber K.; Kirchhofer D.; Presta L.; Kelley R.F.; Muller Y.A.
The 1.85 angstrom resolution crystal structures of tissue factor in complex with humanized Fab D3h44 and of free humanized Fab D3h44: Revisiting the solvation of antigen combining sites
Journal of Molecular Biology 313 (1): 83-97 (2001-01-01)



Umbach P.; Heinemann U.
Die Proteinstrukturfabrik - Strukturanalyse mit hohem Durchsatz im Berliner Forschungsverbund
Biospektrum 7 (3): 247-249 (2001-01-01)



Mueller J.J.; Mueller E.C.; Montag T.; Zyto N.; Loeschner B.; Klein H.; Heineman U.; Otto A.
Characterization and crystallization of a novel Sarcocystis muris lectin, SML-2
Acta Crystallographica Section D 57 (7): 1042-1045 (2001-01-01)



Schwartz T.; Behlke J.; Lowenhaupt K.; Heineman U.; Rich A.
Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins
Nature Structural Biology 8 (9): 761-765 (2001-01-01)



Heinemann U.; Illing G.; Oschkinat H.
High-throughput three-dimensional protein structure determination
Current Opinion in Biotechnology 12 (4): 348-354 (2001-01-01)



Rudenko G.; Hohenester E.; Muller Y.A.
LG/LNS domains: multiple functions - one business end?
Trends in Biochemical Sciences 26 (6): 363-368 (2001-01-01)



Heiring C.; Muller Y.A.
Folding screening assayed by proteolysis: application to various cystine deletion mutants of vascular endothelial growth factor
Protein Engineering 14 (3): 183-188 (2001-01-01)



Mueller J.J.; Lapko A.; Bourenkov G.; Ruckpaul K.; Heinemann U.
Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis
Journal of Biological Chemistry 276 (4): 2786-2789 (2001-01-01)



Gutberlet T.; Heinemann U.; Steiner M.
Protein crystallography with neutrons - status and perspectives
Acta Crystallographica Section D 57 (2): 349-354 (2001-01-01)



2000

Heinemann U.
Structural genomics in Europe: slow start, strong finish?
Nature Structural Biology 7 (Suppl): 940-942 (2000-11-01)



Decanniere K.; Babu A.M.; Sandman K.; Reeve J.N.; Heinemann U.
Crystal structures of recombinant histones HMfA and HMfB from the hyperthermophilic archaeon Methanothermus fervidus
Journal of Molecular Biology 303 (1): 35-47 (2000-10-13)



Grinberg A.V.; Hannemann F.; Schiffler B.; Mueller J.; Heinemann U.; Bernhardt R.
Adrenodoxin: Structure, stability, and electron transfer properties
Proteins: Structure, Function, and Bioinformatics 40: 590-612 (2000-09-01)



Avvakumov G.V.; Muller Y.A.; Hammond G.L.
Steroid-binding specificity of human sex hormone-binding globulin is influenced by occupancy of a zinc-binding site
Journal of Biological Chemistry 275 (34): 25920-25925 (2000-08-25)



Perl D.; Mueller U.; Heinemann U.; Schmid F.X.
Two exposed amino acid residues confer thermostability on a cold shock protein
Nature Structural Biology 7: 380-383 (2000-05-01)



Krafft C.; Diehl A.; Laettig S.; Behlke J.; Heinemann U.; Pon C.L.; Gualerzi C.O.; Welfle H.
Interaction of fMet-tRNAfMet with the C-terminal domain of translational initiation factor IF2 from Bacillus stearothermophilus
FEBS Letters 471 (2-3): 128-132 (2000-04-14)



Mueller U.; Perl D.; Schmid F.X.; Heinemann U.
Thermal stability and atomic-resolution crystal structure of the Bacillus caldolyticus cold shock protein
Journal of Molecular Biology 297 (4): 975-988 (2000-04-07)



Grishkovskaya I.; Avvakumov G.V.; Sklenar G.; Dales D.; Hammond G.L.; Muller Y.A.
Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain
EMBO Journal 19 (4): 504-512 (2000-02-15)



Heinemann U.
Structural biology: the foundation of molecular medicine
Journal of Molecular Medicine 78 (5): 245-246 (2000-01-01)



Wiesmann C.; Muller Y.A.; de Vos A.M.
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases
Journal of Molecular Medicine 78 (5): 247-260 (2000-01-01)



Heineman U.; Frevert J.; Hofman K.P.; Illing G.; Oschkinat H.; Saenger W.; Zettl R.
Linking structural biology with genome research: The Berlin "Protein Structure Factory" initiative
Genomics and Proteomics - Functional and Computational Aspects : 179-189 (2000-01-01)



Heinemann U.; Frevert J.; Hofmann K.P.; Illing G.; Maurer C.; Oschkinat H.; Saenger W.
An integrated approach to structural genomics
Progress in Biophysics & Molecular Biology 73 (5): 347-362 (2000-01-01)



Heinemann U.; Mueller U.; Heumann H.; Sprinzl M.
Structural studies of model RNA helices with relevance to aminoacyl-tRNA synthetase specificity and HIV reverse transcription
Journal of Biomolecular Structure & Dynamics 17 (Special Iss. S1): 39-45 (2000-01-01)



1999

Grishkovskaya I.; Sklenar G.; Avvakumov G.V.; Dales D.; Behlke J.; Hammond G.L.; Muller Y.A.
Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood
Acta Crystallographica Section D 55 (Pt 12): 2053-2055 (1999-12)



Mueller J.J.; Mueller A.; Rottmann M.; Bernhardt R.; Heinemann U.
Vertebrate-type and plant-type ferredoxins: Crystal structure comparison and electron transfer pathway modelling
Journal of Molecular Biology 294 (2): 501-513 (1999-11-26)



Mueller U.; Muller Y.A.; Herbst-Irmer R.; Sprinzl M.; Heinemann U.
Disorder and twin refinement of RNA heptamer double helices
Acta Crystallographica Section D 55 Part 8: 1405-1413 (1999-08-01)



Mueller U.; Schuebel H.; Sprinzl M.; Heinemann U.
Crystal structure of acceptor stem of tRNA(Ala) from Escherichia coli shows unique G * U wobble base pair at 1.16 angstrom resolution
RNA 5: 670-677 (1999-05-01)



Schweiger S.; Foerster J.; Lehman T.; Suckow V.; Muller Y.A.; Walter G.; Davies T.; Porter H.; van Bokhoven H.; Lunt P.W.; Traub P.; Ropers H.H.
The Opitz syndrome gene product, MID1, associates with microtubules
Proceedings of the National Academy of Sciences of the United States of America 96: 2794-2799 (1999-03-16)



Foerster C.; Krafft C.; Welfle H.; Gualerzi C.O.; Heinemann U.
Preliminary characterization by X-ray diffraction and Raman spectroscopy of a crystalline complex of Bacillus stearothermophilus initiation factor 2 C-domain and fMet-tRNA(fMet)
Acta Crystallographica Section D 55 Pt. 3: 712-716 (1999-03-01)



Foerster C.; Eickmann A.; Schubert U.; Hollmann S.; Mueller U.; Heinemann U.; Fuerste J.P.
Crystallization and X-ray diffraction data of a tRNA(Sec) acceptor-stem helix
Acta Crystallographica Section D 55 Pt.3: 664-666 (1999-03-01)



Grossmann J.G.; Hasnain S.S.; Yousafzai F.K.; Smith B.E.; Eady R.R.; Schindelin H.; Kisker C.; Howard J.B.; Tsuruta H.; Mueller J.; Rees D.C.
Comparing crystallographic and solution structures of nitrogenase complexes
Acta Crystallographica Section D 55: 727-728 (1999-01-01)



1998

Muller Y.A.; Chen Y.; Christinger H.W.; Li B.; Cunningham B.C.; Lowman H.B.; deVos A.M.
VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 angstrom resolution and mutational analysis of the interface
Structure 6 (9): 1153-1167 (1998-09-15)



Mueller U.; Maier G.; Onori A.M.; Cellai L.; Heumann H.; Heinemann U.
Crystal structure of an eight-base pair duplex containing the 3'-DNA-RNA-5' junction formed during initiation of minus-strand synthesis of HIV replication
Biochemistry 37: 12005-12011 (1998-09-01)



Ay J.; Goetz F.; Borriss R.; Heinemann U.
Structure and function of the Bacillus hybrid enzyme GluXyn-1: Native-like jellyroll fold preserved after insertion of autonomous globular domain
Proceedings of the National Academy of Sciences of the United States of America 95 (12): 6613-6618 (1998-06-09)



Mueller A.; Mueller J.J.; Muller Y.A.; Uhlmann H.; Bernhardt R.; Heinemann U.
New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108)
Structure 6 (3): 269-280 (1998-03-15)



Mueller J.J.; Thomsen K.K.; Heinemann U.
Crystal structure of barley 1,3-1,4-beta-glucanase at 2.0-A resolution and comparison with Bacillus 1,3-1,4-beta-glucanase
Journal of Biological Chemistry 273 (6): 3438-3446 (1998-02-06)



Muller Y.A.; Heinemann U.
Roentgenstrukturanalyse grosser Biomolekuele. Wie die dreidimensionale Strukturaufklaerung die Biochemie revolutioniert
Chemie in unserer Zeit 32: 22-33 (1998-01-01)



Muller Y.A.; Kelley R.F.; de Vos A.M.
Hinge bending within the cytokine receptor superfamily revealed by the 2.4 A crystal structure of the extracellular domain of rabbit tissue factor
Protein Science 7: 1106-1115 (1998-01-01)



Lukowski G.; Mueller J.J.
Potential modelling of acrylic acid copolymer nanoparticles by small angle X-ray scattering
International Journal of Pharmaceutics 168: 173-179 (1998-01-01)



Vis H.; Heinemann U.; Dobson C.M.; Robinson C.V.
Detection of a monomeric intermediate associated with dimerization of protein HU by mass spectrometry
Journal of the American Chemical Society 120: 6427-6428 (1998-01-01)



Ay J.; Hahn M.; Decanniere K.; Piotukh K.; Borriss R.; Heinemann U.
Crystal structures and properties of de novo circularly permuted 1,3-1,4-beta-glucanases
Proteins: Structure, Function, and Bioinformatics 30: 155-167 (1998-01-01)



Bernhardt R.; Mueller A.; Uhlmann H.; Grinberg A.; Mueller J.J.; Heinemann U.
Structure of adrenodoxin and function in mitochondrial steroid hydroxylation
Endocrine Research 24: 531-539 (1998-01-01)



1997

Muller Y.A.; Christinger H.W.; Keyt B.A.; de Vos A.M.
The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding
Structure with Folding & Design 5 (10): 1325-1338 (1997-10-15)



Lapko A.; Mueller A.; Heese O.; Ruckpaul K.; Heinemann U.
Preparation and crystallization of a cross-linked complex of bovine adrenodoxin and adrenodoxin reductase
Proteins: Structure, Function, and Bioinformatics 28: 289-292 (1997-01-01)



1996

Mueller J.J.; Hansen S.; Puerschel H.V.
The use of small-angle scattering and the maximum-entropy method for shape-model determination from distance-distribution functions
Journal of Applied Crystallography 29 (Pt 5): 547-554 (1996-10-01)



Ott G.; Doerfler S.; Sprinzl M.; Mueller U.; Heinemann U.
Crystals of the chemically synthesized acceptor stem of tRNAala from Escherichia coli diffracting to high resolution
Acta Crystallographica Section D 52 Part 4: 871-873 (1996-01-01)



Hansen S.; Mueller J.J.
The maximum-entropy method in small-angle scattering
Maximum Entropy and Bayesian Methods : 69-78 (1996)



Heinemann U.; Ay J.; Gaiser O.; Mueller J.J.; Ponnuswamy W.N.
Enzymology and folding of natural and engineered bacterial beta-glucanases studied by X- ray crystallography
Biological Chemistry 377: 447-454 (1996-01-01)



Decanniere K.; Sandman K.; Reeve J.; Heinemann U.
Crystallization and preliminary X-ray characterization of the Methanothermus fervidus histones HMfA and HMfB
Proteins: Structure, Function, and Bioinformatics 24: 269-271 (1996-01-01)



1995

Mueller J.J.; Hansen S.; Lukowski G.; Gast K.
Multimodal particle size distribution or fractal surface of acrylic acid copolymer nanoparticles: A small-angle X-ray scattering study using direct Fourier and indirect maximum entropy methods
Journal of Applied Crystallography 28 (Pt 6): 774-781 (1995-12-01)



Mueller J.J.; Gorny H.E.; Schmalz J.; Heinemann U.
Glass-capillary collimator for distance compensation and partial monochromatization at rotating-anode X-ray generators
Journal of Applied Crystallography 28 (Pt 6): 853-855 (1995-12-01)



Engel K.; Schultz H.; Martin F.; Kotlyarov A.; Plath K.; Hahn M.; Heinemann U.; Gaestel M.
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif
Journal of Biological Chemistry 270 (45): 27213-27221 (1995-11-10)



Hahn M.; Olsen O.; Politz O.; Borriss R.; Heinemann U.
Crystal structure and site-directed mutagenesis of Bacillus macerans endo-1,3-1,4-beta-glucanase
Journal of Biological Chemistry 270 (7): 3081-3088 (1995-02-17)



Mueller J.J.; Mueller E.C.; Gernat C.; Kroeber R.
AKIMA interpolation: A tool used in direct slit-length desmearing procedures of non-frequency- limited X-ray scattering curves
Journal of Applied Crystallography 28 (Pt 1): 38-42 (1995-02-01)



Timmermann C.; Behlke J.; Ristau O.; Gerst H.; Heinemann U.
Chemical cross-linking and analytical ultracentrifugation study of the histone-like protein HBsu: Quaternary structure and DNA binding
Progress Colloid Polymers Science 99: 74-81 (1995-01-01)



Hahn M.; Pons J.; Planas A.; Querol E.; Heinemann U.
Crystal structure of Bacillus licheniformis 1,3-1,4-beta-D-glucan 4-glucanohydrolase at 1.8A resolution
FEBS Letters 374: 221-224 (1995-01-01)



Heinemann U.; Hahn M.
Circular permutations of protein sequence: not so rare?
Trends in Biochemical Sciences 20 (9): 349-350 (1995-01-01)



Schindelin H.; Zhang M.; Bald R.; Fuerste J.P.; Erdmann V.A.; Heinemann U.
Crystal structure of an RNA dodecamer containing the Escherichia Coli Shine-Dalgarno sequence
Journal of Molecular Biology 249 (3): 595-603 (1995-01-01)



Mueller J.J.; Gernat C.; Schulz W.; Mueller E.C.; Vorwerg W.; Damaschun G.
Computer simulations of X-ray scattering curves: Gelation and crystallization process in amylose solutions
Biopolymers 35: 271-288 (1995-01-01)



Heinemann U.; Hahn M.
Circular permutation of polypeptide chains: implications for protein folding and stability
Progress in Biophysics & Molecular Biology 64: 121-143 (1995-01-01)



Mueller E.C.; Mueller J.J.
Biopolymer-Modellierung mit erhoehter Strukturaufloesung unter Verwendung von Roentgen-Weitwinkelstreudaten und der Datenbank OBIOSCAT
Strukturuntersuchungen an nichtkristallinen und partiellkristalinen Stoffen : 204-216 (1995)



Hahn M.; Keitel T.; Heinemann U.
Crystal and molecular structure at 0.16-nm resolution of the hybrid Bacillus endo-1,3-1,4-beta-D-glucan 4-glucanohydrolase H(A16-M)
European Journal of Biochemistry 232 (3): 849-858 (1995-01-01)



1994

Mueller J.J.; Hansen S.
A study of high-resolution x-ray scattering data evaluation by the maximum-entropy method
Journal of Applied Crystallography 27 (Pt 3): 257-270 (1994-06-01)



Schindelin H.; Jiang W.; Inouye M.; Heinemann U.
Crystal structure of CspA, the major cold shock protein of Escherichia coli
Proceedings of the National Academy of Sciences of the United States of America 91 (11): 5119-5123 (1994-05-24)



Schindelin H.; Marahiel M.A.; Heinemann U.
The cold shock domain: crystal structures of the major shock protein of Bacillus subtilis
Structural Biology: The State of the Art. Proceedings of the Eighth Conversation, State University of New York, Albany : 83-92 (1994-01-01)



Keitel T.; Meldgaard M.; Heinemann U.
Cation binding to a Bacillus (1,3-1,4)-beta-glucanase. Geometry, affinity and effect on protein stability
European Journal of Biochemistry 222: 203-214 (1994-01-01)



Pletinckx J.; Steyaert J.; Zegers I.; Choe H.W.; Heinemann U.; Wyns L.
Crystallographic study of Glu58Ala RNase T1 x·2'-guanosine monophosphate at 1.9-Å resolution
Biochemistry 33: 1654-1662 (1994-01-01)



Heinemann U.; Alings C.; Hahn M.
Crystallographic studies of DNA helix structure
Biophysical Chemistry 50: 157-167 (1994-01-01)



Hahn M.; Piotukh K.; Borriss R.; Heinemann U.
Native-like in vivo folding of a circularly permuted jellyroll protein shown by crystal structure analysis
Proceedings of the National Academy of Sciences of the United States of America 91: 10417-10421 (1994-01-01)



Hoier H.; Schloemann M.; Hammer A.; Glusker J.P.; Carrell H.L.; Goldmann A.; Stezowski J.J.; Heinemann U.
Crystal structure of chloromuconate cycloisomerase from Alcaligenes eutrophus JMP134 (pJP4) at 3 A resolution
Acta Crystallographica Section D 50: 75-84 (1994-01-01)



Mueller J.J.; Lukowski G.; Kroeber R.; Damaschun G.; Dittgen M.
Acrylic acid copolymer nanoparticles for drug delivery: structural characterization of nanoparticles by small-angle x-ray scattering
Colloid and Polymer Science 272: 755-769 (1994-01-01)



Hahn U.; Heinemann U.
Structure determination, modeling and site-directed mutagenesis studies
Concepts in Protein Egineering and Design. : 109-167 (1994-01-01)



1993

Schindelin H.; Marahiel M.A.; Heinemann U.
Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein
Nature 364 (6433): 164-168 (1993-07-08)



Fabian H.; Hoelzer W.; Heinemann U.; Sklenar H.; Welfle H.
Conformation of d (GGGATCCC) 2 in crystals and in solution studied by X-ray diffraction, Raman spectroscopy and molecular modelling
Nucleic Acids Research 21 (3): 569-576 (1993-02-11)



Keitel T.; Thomsen K.K.; Heinemann U.
Crystallization of barley (1-3,1-4)-beta-glucanase, isoenzyme II
Journal of Molecular Biology 232: 1003-1004 (1993-01-01)



Hahn M.; Heinemann U.
DNA helix structure and refinement algorithm: comparison of models for d(CCAGGCm5CTGG) derived from NUCLSQ, TNT, and X-PLOR
Acta Crystallographica Section D 49: 468-477 (1993-01-01)



Grunert H.P.; Landt O.; Zierpel-Giesebrecht M.; Backmann J.; Heinemann U.; Saenger W.; Hahn U.
Trp59 to Tyr substitution enhances the catalytic activity of RNase T1 and of the Tyr to Trp variants in positions 24, 42, and 45
Protein Engineering 6: 739-744 (1993-01-01)



Welfle H.; Welfle K.; Misselwitz R.; Groch N.; Heinemann U.
Conformational stability of the DNA-binding histone-like protein, HBsu, from Bacillus subtilis, and of the four HBsu variants [F29W],[F47W],[F50W] and [F79W]
Journal of Biomolecular Structure & Dynamics 11: 381-394 (1993-01-01)



Keitel T.; Simon O.; Borriss R.; Heinemann U.
Molecular and active-site structure of a Bacillus (1-3,1-4)-beta-glucanase
Proceedings of the National Academy of Sciences of the United States of America 90: 5287-5291 (1993-01-01)



Groch N.; Hahn U.; Heinemann U.
Synthesis of the Bacillus subtilis histone-like DNA-binding protein HBsu in Escherichia coli and secretion into the periplasm
Gene 124: 99-103 (1993-01-01)



Lenz A.; Choe H.W.; Granzin J.; Heinemann U.; Saenger W.
Three-dimensional structure of the ternary complex between ribonuclease T1, guanosine 3',5'-bisphosphate and inorganic phosphate at 0.19 nm resolution
European Journal of Biochemistry 211: 311-316 (1993-01-01)



Welfle H.; Misselwitz R.; Welfle K.; Schindelin H.; Scholtz A.S.; Heinemann U.
Conformations and conformational changes of four Phe->Trp variants of the DNA-binding histone-like protein, HBsu, from Bacillus subtilis studied by circular dichroism and fluorescence spectroscopy
European Journal of Biochemistry 217: 849-856 (1993-01-01)