Publications



2017

Lorenz F.K.M.; Ellinger C.; Kieback E.; Wilde S.; Lietz M.; Schendel D.J.; Uckert W.
Unbiased identification of T cell receptors targeting immunodominant peptide-MHC complexes for T cell receptor immunotherapy
Human Gene Therapy : (2017-09-26)



Wisskirchen K.; Metzger K.; Schreiber S.; Asen T.; Weigand L.; Dargel C.; Witter K.; Kieback E.; Sprinzl M.F.; Uckert W.; Schiemann M.; Busch D.H.; Krackhardt A.M.; Protzer U.
Isolation and functional characterization of hepatitis B virus-specific T-cell receptors as new tools for experimental and clinical use
PLoS ONE 12 (8): e0182936 (2017-08-08)



Schlenker R.; Olguin-Contreras L.F.; Leisegang M.; Schnappinger J.; Disovic A.; Ruehland S.; Nelson P.J.; Leonhardt H.; Harz H.; Wilde S.; Schendel D.J.; Uckert W.; Willimsky G.; Noessner E.
Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy
Cancer Research 77 (13): 3577-3590 (2017-07)



Kammertoens T.; Friese C.; Arina A.; Idel C.; Briesemeister D.; Rothe M.; Ivanov A.; Szymborska A.; Patone G.; Kunz S.; Sommermeyer D.; Engels B.; Leisegang M.; Textor A.; Fehling H.J.; Fruttiger M.; Lohoff M.; Herrmann A.; Yu H.; Weichselbaum R.; Uckert W.; Huebner N.; Gerhardt H.; Beule D.; Schreiber H.; Blankenstein T.
Tumour ischaemia by interferon-{gamma} resembles physiological blood vessel regression
Nature 545 (7652): 98-102 (2017-05-04)



Schultz A.S.; Preussner M.; Bunse M.; Karni R.; Heyd F.
Activation-dependent TRAF3 exon 8 alternative splicing is controlled by CELF2 and hnRNP C binding to an upstream intronic element
Molecular and Cellular Biology 37 (7): e.00488-16 (2017-04)



2016

Bethune M.T.; Gee M.H.; Bunse M.; Lee M.S.; Gschweng E.H.; Pagadala M.S.; Zhou J.; Cheng D.; Heath J.R.; Kohn D.B.; Kuhns M.S.; Uckert W.; Baltimore D.
Domain-swapped T cell receptors improve the safety of TCR gene therapy
eLife 5: e19095 (2016-11-08)



Richter M.; Saydaminova K.; Yumul R.; Krishnan R.; Liu J.; Nagy E.E.; Singh M.; Izsvak Z.; Cattaneo R.; Uckert W.; Palmer D.; Ng P.; Haworth K.G.; Kiem H.P.; Ehrhardt A.; Papayannopoulou T.; Lieber A.
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors
Blood 128 (18): 2206-2217 (2016-11-03)



Ku M.C.; Edes I.; Bendix I.; Pohlmann A.; Waiczies H.; Prozorovski T.; Guenter M.; Martin C.; Pages G.; Wolf S.A.; Kettenmann H.; Uckert W.; Niendorf T.; Waiczies S.
ERK1 as a therapeutic target for dendritic cell vaccination against high-grade gliomas
Molecular Cancer Therapeutics 15 (8): 1975-1987 (2016-08)



Leisegang M.; Engels B.; Schreiber K.; Yew P.Y.; Kiyotani K.; Idel C.; Arina A.; Duraiswamy J.; Weichselbaum R.R.; Uckert W.; Nakamura Y.; Schreiber H.
Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation
Clinical Cancer Research 22 (11): 2734-2743 (2016-06-01)



Kieback E.; Hilgenberg E.; Stervbo U.; Lampropoulou V.; Shen P.; Bunse M.; Jaimes Y.; Boudinot P.; Radbruch A.; Klemm U.; Kuehl A.A.; Liblau R.; Hoevelmeyer N.; Anderton S.M.; Uckert W.; Fillatreau S.
Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity
Immunity 44 (5): 1114-1126 (2016-05-17)



Schirmer D.; Gruenewald T.G.P.; Klar R.; Schmidt O.; Wohlleber D.; Rubio R.A.; Uckert W.; Thiel U.; Bohne F.; Busch D.H.; Krackhardt A.M.; Burdach S.; Richter G.H.S.
Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity
OncoImmunology 5 (6): e1175795 (2016-04-25)



Ebstein F.; Textoris-Taube K.; Keller C.; Golnik R.; Vigneron N.; Van den Eynde B.J.; Schuler-Thurner B.; Schadendorf D.; Lorenz F.K.M.; Uckert W.; Urban S.; Lehmann A.; Albrecht-Koepke N.; Janek K.; Henklein P.; Niewienda A.; Kloetzel P.M.; Mishto M.
Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes
Scientific Reports 6: 24032 (2016-04-06)



Gogol-Doering A.; Ammar I.; Gupta S.; Bunse M.; Miskey C.; Chen W.; Uckert W.; Schulz T.F.; Izsvak Z.; Ivics Z.
Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4+ T cells
Molecular Therapy 24 (3): 592-606 (2016-03)



Leisegang M.; Kammertoens T.; Uckert W.; Blankenstein T.
Targeting human melanoma neoantigens by T cell receptor gene therapy
Journal of Clinical Investigation 126 (3): 854-858 (2016-03-01)



Mensali N.; Ying F.; Sheng V.O.Y.; Yang W.; Walseng E.; Kumari S.; Fallang L.E.; Kolstad A.; Uckert W.; Malmberg K.J.; Waelchli S.; Olweus J.
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
OncoImmunology 5 (5): e1138199 (2016-02-18)



2015

Dargel C.; Bassani-Sternberg M.; Hasreiter J.; Zani F.; Bockmann J.H.; Thiele F.; Bohne F.; Wisskirchen K.; Wilde S.; Sprinzl M.F.; Schendel D.J.; Krackhardt A.M.; Uckert W.; Wohlleber D.; Schiemann M.; Stemmer K.; Heikenwaelder M.; Busch D.H.; Richter G.; Mann M.; Protzer U.
T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice
Gastroenterology 149 (4): 1042-1052 (2015-10)



Leisegang M.; Uckert W.
Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Moeglichkeiten fuer die Immuntherapie von Krebs]
BIOspektrum 21 (4): 402-405 (2015-06)



Obenaus M.; Leitao C.; Leisegang M.; Chen X.; Gavvovidis I.; van der Bruggen P.; Uckert W.; Schendel D.J.; Blankenstein T.
Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice
Nature Biotechnology 33 (4): 402-407 (2015-04)



Blankenstein T.; Leisegang M.; Uckert W.; Schreiber H.
Targeting cancer-specific mutations by T cell receptor gene therapy
Current Opinion in Immunology 33: 112-119 (2015-04)



Lorenz F.K.M.; Wilde S.; Voigt K.; Kieback E.; Mosetter B.; Schendel D.J.; Uckert W.
Codon optimization of the human papillomavirus E7 oncogene induces a CD8+ T cell response to a cryptic epitope not harbored by wild-type E7
PLoS ONE 10 (3): e0121633 (2015-03-23)



Ghorashian S.; Velica P.; Chua I.; McNicol A.; Carpenter B.; Holler A.; Nicholson E.; Ahmadi M.; Zech M.; Xue S.; Uckert W.; Morris E.; Chakraverty R.; Stauss H.J.
CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor
Journal of Immunology 194 (3): 1080-1089 (2015-02-01)



Stoycheva D.; Deiser K.; Staerck L.; Nishanth G.; Schlueter D.; Uckert W.; Schueler T.
IFN-{gamma} regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals
Journal of Immunology 194 (2): 553-559 (2015-01-15)



2014

Hennig K.; Raasch L.; Kolbe C.; Weidner S.; Leisegang M.; Uckert W.; Titeux M.; Hovnanian A.; Kuehlcke K.; Loew R.
HEK293-based production platform for {gamma}-retroviral (SIN-) vectors: application for safe and efficient transfer of COL7A1 cDNA
Human Gene Therapy Clinical Development 25 (4): 218-228 (2014-12)



Bunse M.; Bendle G.M.; Linnemann C.; Bies L.; Schulz S.; Schumacher T.N.; Uckert W.
RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer
Molecular Therapy 22 (11): 1983-1991 (2014-11)



Gomez-Eerland R.; Nuijen B.; Heemskerk B.; van Rooij N.; van den Berg J.H.; Beijnen J.H.; Uckert W.; Kvistborg P.; Schumacher T.; Haanen J.B.A.G.; Jorritsma A.
Manufacture of gene modified human T cells with a memory stem/ central memory phenotype
Human Gene Therapy Methods 25 (5): 277-287 (2014-10)



Pinto S.; Sommermeyer D.; Michel C.; Wilde S.; Schendel D.; Uckert W.; Blankenstein T.; Kyewski B.
Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells
European Journal of Immunology 44 (9): 2811-2821 (2014-09)



Lehmann F.M.; Maurberger A.; Feicht S.; Helm F.; Ladinig C.; Kieback E.; Uckert W.; Kammertoens T.; Kremmer E.; Mautner J.; Gerbitz A.; Bornkamm G.W.
Targeting high-grade B cell lymphoma with CD19-specific T cells
International Journal of Cancer 135 (5): 1153-1164 (2014-09-01)



Staerck L.; Popp K.; Pircher H.; Uckert W.
Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells
Journal of Immunology 192 (1): 206-213 (2014-01-01)



Reuss S.; Sebestyen Z.; Heinz N.; Loew R.; Baum C.; Debets R.; Uckert W.
TCR-engineered T cells: a model of inducible TCR expression to dissect the interrelationship between two TCRs
European Journal of Immunology 44 (1): 265-274 (2014-01)



Kieback E.; Hilgenberg E.; Fillatreau S.
A method for the generation of TCR retrogenic mice
Methods in Molecular Biology 1193: 117-126 (2014)



2013

Smith S.N.; Sommermeyer D.; Piepenbrink K.H.; Blevins S.J.; Bernhard H.; Uckert W.; Baker B.M.; Kranz D.M.
Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes
Journal of Molecular Biology 425 (22): 4496-4507 (2013-11-15)



Krebs K.; Boettinger N.; Huang L.R.; Chmielewski M.; Arzberger S.; Gasteiger G.; Jaeger C.; Schmitt E.; Bohne F.; Aichler M.; Uckert W.; Abken H.; Heikenwalder M.; Knolle P.; Protzer U.
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelop proteins control virus replication in mice
Gastroenterology 145 (2): 456-465 (2013-08)



Nauerth M.; Weissbrich B.; Knall R.; Franz T.; Doessinger G.; Bet J.; Paszkiewicz P.J.; Pfeifer L.; Bunse M.; Uckert W.; Holtappels R.; Gillert-Marien D.; Neuenhahn M.; Krackhardt A.; Reddehase M.J.; Riddell S.R.; Busch D.H.
TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer
Science Translational Medicine 5 (192): 192ra87 (2013-07-03)



Doessinger G.; Bunse M.; Bet J.; Albrecht J.; Paszkiewicz P.J.; Weissbrich B.; Schiedewitz I.; Henkel L.; Schiemann M.; Neuenhahn M.; Uckert W.; Busch D.H.
MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy
PLoS ONE 8 (4): e61384 (2013-04-26)



Sommermeyer D.; Conrad H.; Kroenig H.; Gelfort H.; Bernhard H.; Uckert W.
NY-ESO-1 antigen-reactive T cell receptors exhibit diverse therapeutic capability
International Journal of Cancer 132 (6): 1360-1367 (2013-03-15)



2012

Zhou Q.; Schneider I.C.; Edes I.; Honegger A.; Bach P.; Schoenfeld K.; Schambach A.; Wels W.S.; Kneissl S.; Uckert W.; Buchholz C.J.
T cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing
Blood 120 (22): 4334-4342 (2012-11-22)



Mueller K.; von Maessenhausen A.; Aichele U.; Staerck L.; Leisegang M.; Uckert W.; Pircher H.
Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo
Journal of Virology 86 (19): 10866-10869 (2012-10)



Wilde S.; Sommermeyer D.; Leisegang M.; Frankenberger B.; Mosetter B.; Uckert W.; Schendel D.J.
Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition
Journal of Immunology 189 (2): 598-605 (2012-07-15)



Spranger S.; Jeremias I.; Wilde S.; Leisegang M.; Staerck L.; Mosetter B.; Uckert W.; Heemskerk M.H.M.; Schendel D.J.; Frankenberger B.
TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo
Blood 119 (15): 3440-3449 (2012-04-12)



2011

Popovic J.; Li L.P.; Kloetzel P.M.; Leisegang M.; Uckert W.; Blankenstein T.
The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed
Blood 118 (4): 946-954 (2011-07-28)



Seifert S.; Pannell M.; Uckert W.; Faerber K.; Kettenmann H.
Transmitter- and hormone-activated Ca(2+) responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca(2+) sensor
Cell Calcium 49 (6): 365-375 (2011-06)



Briesemeister D.; Sommermeyer D.; Loddenkemper C.; Loew R.; Uckert W.; Blankenstein T.; Kammertoens T.
Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis
International Journal of Cancer 128 (2): 371-378 (2011-01-15)



2010

Meyerhuber P.; Conrad H.; Staerck L.; Leisegang M.; Busch D.H.; Uckert W.; Bernhard H.
Targeting the epidermal growth factor receptor (HER) family by T cell receptor gene-modified T lymphocytes
Journal of Molecular Medicine 88 (11): 1113-1121 (2010-11)



Leisegang M.; Wilde S.; Spranger S.; Milosevic S.; Frankenberger B.; Uckert W.; Schendel D.J.
MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors
Journal of Clinical Investigation 120 (11): 3869-3877 (2010-11-01)



Buening H.; Uckert W.; Cichutek K.; Hawkins R.E.; Abken H.
Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events
Human Gene Therapy 21 (9): 1039-1042 (2010-09)



Merz H.; Kaehler C.; Hoefig K.P.; Branke B.; Uckert W.; Nadrowitz R.; Cerny-Reiterer S.; Herrmann H.; Feller A.C.; Valent P.
Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice
Oncotarget 1 (2): 104-119 (2010-06-07)



Sommermeyer D.; Uckert W.
Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells
Journal of Immunology 184 (11): 6223-6231 (2010-06-01)



Kieback E.; Uckert W.
Enhanced T cell receptor gene therapy for cancer
Expert Opinion on Biological Therapy 10 (5): 749-762 (2010-05)



Bendle G.M.; Linnemann C.; Hooijkaas A.I.; Bies L.; de Witte M.A.; Jorritsma A.; Kaiser A.D.M.; Pouw N.; Debets R.; Kieback E.; Uckert W.; Song J.Y.; Haanen J.B.A.G.; Schumacher T.N.M.
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
Nature Medicine 16 (5): 565-570, 1p following 570 (2010-05)



Leisegang M.; Turqueti-Neves A.; Engels B.; Blankenstein T.; Schendel D.J.; Uckert W.; Noessner E.
T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy
Clinical Cancer Research 16 (8): 2333-2343 (2010-04-15)



Liang X.; Weigand L.U.; Schuster I.G.; Eppinger E.; van der Griendt J.C.; Schub A.; Leisegang M.; Sommermeyer D.; Anderl F.; Han Y.; Ellwart J.; Moosmann A.; Busch D.H.; Uckert W.; Peschel C.; Krackhardt A.M.
A single TCR{alpha}-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire
Journal of Immunology 184 (3): 1617-1629 (2010-02-01)



2009

Wilde S.; Sommermeyer D.; Frankenberger B.; Schiemann M.; Milosevic S.; Spranger S.; Pohla H.; Uckert W.; Busch D.H.; Schendel D.J.
Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity
Blood 114 (10): 2131-2139 (2009-09-03)



Rueder C.; Hoepken U.E.; Wolf J.; Mittruecker H.W.; Engels B.; Erdmann B.; Wollenzin S.; Uckert W.; Doerken B.; Rehm A.
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells
Journal of Clinical Investigation 119 (8): 2184-2203 (2009-08)



Uckert W.; Schumacher T.N.
TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008
Cancer Immunology Immunotherapy 58 (5): 809-822 (2009-05)



2008

Walzlein J.H.; Synowitz M.; Engels B.; Markovic D.S.; Gabrusiewicz K.; Nikolaev E.; Yoshikawa K.; Kaminska B.; Kempermann G.; Uckert W.; Kaczmarek L.; Kettenmann H.; Glass R.
The antitumorigenic response of neural precursors depends on subventricular proliferation and age
Stem Cells 26 (11): 2945-2954 (2008-11)



Leisegang M.; Engels B.; Meyerhuber P.; Kieback E.; Sommermeyer D.; Xue S.A.; Reuss S.; Stauss H.; Uckert W.
Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette
Journal of Molecular Medicine 86 (5): 573-583 (2008-05)



Kieback E.; Charo J.; Sommermeyer D.; Blankenstein T.; Uckert W.
A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
Proceedings of the National Academy of Sciences of the United States of America 105 (2): 623-628 (2008-01-15)



2007

Nassenstein C.; Kammertoens T.; Veres T.Z.; Uckert W.; Spies E.; Fuchs B.; Krug N.; Braun A.
Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR
Journal of Allergy and Clinical Immunology 120 (5): 1089-1096 (2007-11)



Weinhold M.; Sommermeyer D.; Uckert W.; Blankenstein T.
Dual T cell receptor expressing CD8+ T cells with tumor- and self-specificity can inhibit tumor growth without causing severe autoimmunity
Journal of Immunology 179 (8): 5534-5542 (2007-10-15)



McNicol A.M.; Bendle G.; Holler A.; Matjeka T.; Dalton E.; Rettig L.; Zamoyska R.; Uckert W.; Xue S.A.; Stauss H.J.
CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR
European Journal of Immunology 37 (6): 1634-1641 (2007-06)



Reuss S.; Biese P.; Cosset F.L.; Takeuchi Y.; Uckert W.
Suspension packaging cell lines for the simplified generation of T-cell receptor encoding retrovirus vector particles
Gene Therapy 14 (7): 595-603 (2007-04)



Engels B.; Uckert W.
Redirecting T lymphocyte specificity by T cell receptor gene transfer - a new era for immunotherapy
Molecular Aspects of Medicine 28 (1): 115-142 (2007-02)



2006

Sommermeyer D.; Neudorfer J.; Weinhold M.; Leisegang M.; Engels B.; Noessner E.; Heemskerk M.H.; Charo J.; Schendel D.J.; Blankenstein T.; Bernhard H.; Uckert W.
Designer T cells by T cell receptor replacement
European Journal of Immunology 36 (11): 3052-3059 (2006-11)



Bleifuss E.; Kammertoens T.; Hutloff A.; Quarcoo D.; Dorner M.; Straub P.; Uckert W.; Hildt E.
The translocation motif of hepatitis B virus improves protein vaccination
Cellular and Molecular Life Sciences 63: 627-635 (2006-03)



Kieback E.; Mueller M.
Factors influencing subcellular localization of the human papillomavirus L2 minor structural protein
Virology 345 (1): 199-208 (2006-02-05)



Mathas S.; Janz M.; Hummel F.; Hummel M.; Wollert-Wulf B.; Lusatis S.; Anagnostopoulos I.; Lietz A.; Sigvardsson M.; Jundt F.; Joehrens K.; Bommert K.; Stein H.; Doerken B.
Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
Nature Immunology 7 (2): 207-215 (2006-02)



Bandapalli O.R.; Geheeb M.; Kobelt D.; Kuehnle K.; Elezkurtaj S.; Herrmann J.; Gressner A.M.; Weiskirchen R.; Beule D.; Bluethgen N.; Herzel H.; Franke C.; Brand K.
Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases
International Journal of Cancer 118: 74-89 (2006-01-01)



2005

Xue S.A.; Gao L.; Hart D.; Gillmore R.; Qasim W.; Thrasher A.; Apperley J.; Engels B.; Uckert W.; Morris E.; Stauss H.J.
Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene transduced human T cells
Blood 106: 3062-3067 (2005-07-14)



Engels B.; Noessner E.; Frankenberger B.; Blankenstein T.; Schendel D.J.; Uckert W.
Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes
Human Gene Therapy 16 (7): 799-810 (2005-07-01)



Uckert W.; Blankenstein T.
Gentherapie mit T-Zellrezeptor modifizierten Zellen
BioForum 28 (3): 27-30 (2005-05-20)



Hieronymus T.; Gust T.C.; Kirsch R.D.; Jorgas T.; Blendinger G.; Goncharenko M.; Supplitt K.; Rose-John S.; Mueller A.M.; Zenke M.
Progressive and controlled development of mouse dendritic cells from Flt3+ CD11b+ progenitors in vitro
Journal of Immunology 174 (5): 2552-2562 (2005-01-01)



Kammertoens T.; Willebrand R.; Erdmann B.; Li L.; Li Y.; Engels B.; Uckert W.; Blankenstein T.
CY15, a malignant histiocytic tumor that is phenotypically similar to immature dendritic cells
Cancer Research 65: 2560-2564 (2005-01-01)



2004

Elezkurtaj S.; Kopitz C.; Baker A.H.; Perez-Canto A.; Arlt M.J.; Khokha R.; Gansbacher B.; Anton M.; Brand K.; Krueger A.
Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis
Journal of Gene Medicine 6 (11): 1228-1237 (2004-09-23)



Gladow M.; Uckert W.; Blankenstein T.
Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors
European Journal of Immunology 34 (7): 1882-1891 (2004-07-01)



Tietge U.J.F.; Cichon G.; Buettner C.; Genschel J.; Heeren J.; Gielow P.; Grewe N.; Dogar M.; Beisiegel U.; Manns M.P.; Lochs H.; Burchert W.; Schmidt H.H.J.
A sensitive noninvasive method for monitoring successful liver-directed gene transfer of the low-density lipoprotein receptor in Watanabe hyperlipidemic rabbits in vivo
Gene Therapy 11 (7): 574-580 (2004-04)



Cichon G.; Willnow T.E.; Herwig S.; Uckert W.; Loeser P.; Schmidt H.H.; Benhidjeb T.; Schlag P.M.; Schnieders F.; Niedzielska D.; Heeren J.
Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage
Journal of Gene Medicine 6 (2): 166-175 (2004-02)



Kuemin D.; Hofmann C.; Uckert W.; Both G.W.; Loeser P.
Identification of an ovine atadenovirus gene whose product activates the viral E2 promoter: possible involvement of E2F-1
Virology 318 (1): 79-89 (2004-01-05)



Uckert W.; Salmons B.; Beltinger C.; Guenzburg W.H.; Kammertoens T.
Combination suicide gene therapy
Suicide Gene Therapy : Methods and Reviews : 345-352 (2004-01-01)



Wuest T.; Both G.W.; Prince A.M.; Hofmann C.; Loeser P.
Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice
Vaccine 22 (21-22): 2717-2721 (2004-01-01)



2003

Muehlebach M.D.; Schmitt I.; Steidl S.; Stitz J.; Schweizer M.; Blankenstein T.; Cichutek K.; Uckert W.
Transduction efficiency of MLV but not of HIV-1 vectors is pseudotype dependent on human primary T lymphocytes
Journal of Molecular Medicine 81 (12): 801-810 (2003-12)



Loeser P.; Hofmann C.; Both G.W.; Uckert W.; Hillgenberg M.
Construction, rescue, and characterization of vectors derived from ovine atadenovirus
Journal of Virology 77 (22): 11941-11951 (2003-11)



Engels B.; Cam H.; Schueler T.; Indraccolo S.; Gladow M.; Baum C.; Blankenstein T.; Uckert W.
Retroviral vectors for high-level transgene expression in T lymphocytes
Human Gene Therapy 14 (12): 1155-1168 (2003-08-10)



Cichon G.; Boeckh-Herwig S.; Kuemin D.; Hoffmann C.; Schmidt H.H.; Wehnes E.; Haensch W.; Schneider U.; Eckhardt U.; Burger R.; Pring-Akerblom P.
Titer determination of Ad5 in blood: a cautionary note
Gene Therapy 10 (12): 1012-1017 (2003-06)



Lange K.; Uckert W.; Blankenstein T.; Nadrowitz R.; Bittner C.; Renauld J.C.; van Snick J.; Feller A.C.; Merz H.
Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice
Oncogene 22 (4): 517-527 (2003-01-30)



Merz H.; Lange K.; Nadrowitz R.; Uckert W.; Blankenstein T.; Feller A.C.
Die Ueberexpression von NPM-ALK in haematopoietischen Stammzellen induziert verschiedene maligne Non-Hodgkin-Lymphome in der IL-9 transgenen Maus [Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice]
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87: 224-231 (2003-01-01)



2002

Kuemin D.; Hofmann C.; Rudolph M.; Both G.W.; Loeser P.
Biology of ovine adenovirus infection of nonpermissive cells
Journal of Virology 76: 10882-10893 (2002-11-01)



Koehler N.K.; Genain C.P.; Giesser B.; Hauser S.L.
The human T cell response to myelin oligodendrocyte glycoprotein: a multiple sclerosis family-based study
Journal of Immunology 168: 5920-5927 (2002-06-01)



Cichon G.; Boeckh-Herwig S.; Elezkurtaj S.; Schmidt H.H.; Hofmann C.; Arnold W.
Hepatocarcinoma cells constitutively expressing adenoviral E1-genes provide a tumor model for intratumoral replication of E1-deficient adenoviruses
Anticancer Research 22 (1A): 197-201 (2002-05)



2001

Cichon G.; Boeckh-Herwig S.; Schmidt H.H.; Wehnes E.; Mueller T.; Pring-Akerblom P.; Burger R.
Complement activation by recombinant adenoviruses
Gene Therapy 8: 1794-1800 (2001-12-01)



Beltinger C.; Uckert W.; Debatin K.M.
Suicide gene therapy for pediatric tumors
Journal of Molecular Medicine 78 (11): 598-612 (2001-01-01)



2000

Loeser P.; Hillgenberg M.; Arnold W.; Both G.W.; Hofmann C.
Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle
Gene Therapy 7: 1491-1498 (2000-09-01)



Kammertoens T.; Gelbmann W.; Karle P.; Alton K.; Saller R.; Salmons B.; Guenzburg W.H.; Uckert W.
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine
Cancer Gene Therapy 7 (4): 629-636 (2000-04-01)



Indraccolo S.; Minuzzo S.; Habeler W.; Zamarchi R.; Fregonese A.; Guenzburg W.H.; Salmons B.; Uckert W.; Chieco-Bianchi L.; Amadori A.
Modulation of moloney leukemia virus long terminal repeat transcriptionalactivity by the murine CD4 silencer in retroviral vectors
Virology 276: 83-92 (2000-01-01)



Gladow M.; Becker C.; Blankenstein T.; Uckert W.
MLV-10A1 retrovirus pseudotype efficiently transduces primary human CD4+ T lymphocytes
Journal of Gene Medicine 2 (6): 409-415 (2000-01-01)



Beltinger C.; Fulda S.; Kammertoens T.; Uckert W.; Debatin K.M.
Mitochondrial amplification of death signals determines thymidine kinase/ ganciclovir-triggered activation of apoptosis
Cancer Research 60 (12): 3212-3217 (2000-01-01)



Stitz J.; Buchholz C.J.; Engelstaedter M.; Uckert W.; Bloemer U.; Schmitt I.; Cichutek K.
Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1
Virology 273 (1): 16-20 (2000-01-01)



Uckert W.; Pedersen L.; Guenzburg W.
Green fluorescent protein retroviral vector. Generation of high-titer producer cells and virus supernatant
Gene Therapy of Cancer : Methods and Protocols : 275-285 (2000-01-01)



Ott M.; Schmidt H.H.J.; Cichon G.; Manns M.P.
Emerging therapies in hepatology: Liver-directed gene transfer and hepatocyte transplantation
Cells Tissues Organs 167 (2-3): 81-87 (2000-01-01)



Uckert W.; Becker C.; Gladow M.; Klein D.; Kammertoens T.; Pedersen L.; Blankenstein T.
Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype
Human Gene Therapy 11 (7): 1005-1014 (2000-01-01)



1999

Heeren J.; Steinwaerder D.S.; Schnieders F.; Cichon G.; Strauss M.; Beisiegel U.
Nonphysiological overexpression of low-density lipoprotein receptors causes pathological intracellular lipid accumulation and the formation of cholesterol and cholesteryl ester crystals in vitro
Journal of Molecular Medicine 77 (10): 735-743 (1999-10)



Cichon G.; Schmidt H.H.; Benhidjeb T.; Loeser P.; Ziemer S.; Haas R.; Grewe N.; Schnieders F.; Heeren J.; Manns M.P.; Schlag P.M.; Strauss M.
Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits
Journal of Gene Medicine 1: 360-371 (1999-09-01)



Hofmann C.; Loeser P.; Cichon G.; Arnold W.; Both G.W.; Strauss M.
Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo
Journal of Virology 73: 6930-6936 (1999-08-01)



Beltinger C.; Fulda S.; Kammertoens T.; Meyer E.; Uckert W.; Debatin K.M.
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases
Proceedings of the National Academy of Sciences of the United States of America 96: 8699-8704 (1999-07-20)



Cichon G.; Strauss M.
Gene Therapy of Familial Hypercholesterolemia
Gene therapy :Principles and Applications : 151-167 (1999-01-01)



1998

Uckert W.; Kammertoens T.; Haack K.; Qin Z.; Gebert J.; Schendel D.J.; Blankenstein T.
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo
Human Gene Therapy 9: 855-865 (1998-01-01)



Uckert W.; Willimsky G.; Pedersen F.S.; Blankenstein T.; Pedersen L.
RNA levels of human retrovirus receptors Pit1 and Pit2 do not correlate with infectibility by three retroviral vector pseudotypes
Human Gene Therapy 9: 2619-2627 (1998-01-01)



Uckert W.; Walther W.; Stein U.
Large and small scale RNA preparations from eukaryotic cells
RNA Isolation and Characterization Protocols : 7-14 (1998-01-01)



Cichon G.; Strauss M.
Transient immunosuppression with 15-deoxyspergualin prolongs reporter gene expression and reduces humoral immune response after adenoviral gene transfer
Gene Therapy 5: 85-90 (1998-01-01)



1995

Uckert W.; Walther W.; Hummel O.
Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines
International Journal of Oncology 6: 1027-1031 (1995-01-01)



1994

Uckert W.; Walther W.
Retrovirus-mediated gene transfer in cancer therapy
Pharmacology & Therapeutics 63: 323-347 (1994-01-01)



Sparmann G.; Walther W.; Guenzburg W.H.; Uckert W.; Salmons B.
Conditional expression of human TNF-alpha: a system for inducible cytotoxicity
International Journal of Cancer 59: 103-107 (1994-01-01)



1993

Walther W.; Fichtner I.; Uckert W.
Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition
Anticancer Research 13: 1565-1574 (1993-01-01)



1992

Walther W.; Huth J.; Sparmann G.; Uckert W.
Retroviral transduction of the human TNF alpha gene into tumour cells generates a growth inhibitory effect
European Biotechnology Today : 209-216 (1992-01-01)