Publications



2017

Piechotta M.; Wyler E.; Ohler U.; Landthaler M.; Dieterich C.
JACUSA: site-specific identification of RNA editing events from replicate sequencing data
BMC Bioinformatics 18 (1): 7 (2017-01-03)



2016

Chekulaeva M.; Landthaler M.
Eyes on translation
Molecular Cell 63 (6): 918-925 (2016-09-15)



Hasler D.; Lehmann G.; Murakawa Y.; Klironomos F.; Jakob L.; Graesser F.A.; Rajewsky N.; Landthaler M.; Meister G.
The Lupus autoantigen La prevents Mis-channeling of tRNA fragments into the human microRNA pathway
Molecular Cell 63 (1): 110-124 (2016-07-07)



Wessels H.H.; Imami K.; Baltz A.G.; Kolinksi M.; Beldovskaya A.; Selbach M.; Small S.; Ohler U.; Landthaler M.
The mRNA-bound proteome of the early fly embryo
Genome Research 26 (7): 1000-1009 (2016-07)



Giedl J.; Rogler A.; Wild A.; Riener M.O.; Filbeck T.; Burger M.; Ruemmele P.; Hurst C.; Knowles M.; Hartmann A.; Zinnall U.; Stoehr R.
TERT core promotor mutations in early-onset bladder cancer
Journal of Cancer 7 (8): 915-920 (2016-05-07)



Calviello L.; Mukherjee N.; Wyler E.; Zauber H.; Hirsekorn A.; Selbach M.; Landthaler M.; Obermayer B.; Ohler U.
Detecting actively translated open reading frames in ribosome profiling data
Nature Methods 13 (2): 165-170 (2016-02)



2015

Bish R.; Cuevas-Polo N.; Cheng Z.; Hambardzumyan D.; Munschauer M.; Landthaler M.; Vogel C.
Comprehensive protein interactome analysis of a key RNA helicase: detection of novel stress granule proteins
Biomolecules 5 (3): 1441-1466 (2015-07-15)



Murakawa Y.; Hinz M.; Mothes J.; Schuetz A.; Uhl M.; Wyler E.; Yasuda T.; Mastrobuoni G.; Friedel C.C.; Doelken L.; Kempa S.; Schmidt-Supprian M.; Bluethgen N.; Backofen R.; Heinemann U.; Wolf J.; Scheidereit C.; Landthaler M.
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-{kappa}B pathway
Nature Communications 6: 7367 (2015-07-14)



Kuespert M.; Murakawa Y.; Schaeffler K.; Vanselow J.T.; Wolf E.; Juranek S.; Schlosser A.; Landthaler M.; Fischer U.
LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation
RNA 21 (7): 1294-1305 (2015-07)



Mino T.; Murakawa Y.; Fukao A.; Vandenbon A.; Wessels H.H.; Ori D.; Uehata T.; Tartey S.; Akira S.; Suzuki Y.; Vinuesa C.G.; Ohler U.; Standley D.M.; Landthaler M.; Fujiwara T.; Takeuchi O.
Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms
Cell 161 (5): 1058-1073 (2015-05-21)



Hosp F.; Vossfeldt H.; Heinig M.; Vasiljevic D.; Arumughan A.; Wyler E.; Landthaler M.; Hubner N.; Wanker E.E.; Lannfelt L.; Ingelsson M.; Lalowski M.; Voigt A.; Selbach M.
Quantitative interaction proteomics of neurodegenerative disease proteins
Cell Reports 11 (7): 1134-1146 (2015-05-19)



Blin K.; Dieterich C.; Wurmus R.; Rajewsky N.; Landthaler M.; Akalin A.
DoRiNA 2.0-upgrading the doRiNA database of RNA interactions in post-transcriptional regulation
Nucleic Acids Research 43 (Database issue): D160-D167 (2015-01-28)



Ivanov A.; Memczak S.; Wyler E.; Torti F.; Porath H.T.; Orejuela M.R.; Piechotta M.; Levanon E.Y.; Landthaler M.; Dieterich C.; Rajewsky N.
Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals
Cell Reports 10 (2): 170-177 (2015-01-13)



2014

Schuetz A.; Murakawa Y.; Rosenbaum E.; Landthaler M.; Heinemann U.
Roquin binding to target mRNAs involves a winged helix-turn-helix motif
Nature Communications 5: 5701 (2014-12-11)



Rybak-Wolf A.; Jens M.; Murakawa Y.; Herzog M.; Landthaler M.; Rajewsky N.
A variety of dicer substrates in human and C. elegans
Cell 159 (5): 1153-1167 (2014-11-20)



Maatz H.; Jens M.; Liss M.; Schafer S.; Heinig M.; Kirchner M.; Adami E.; Rintisch C.; Dauksaite V.; Radke M.H.; Selbach M.; Barton P.J.R.; Cook S.A.; Rajewsky N.; Gotthardt M.; Landthaler M.; Hubner N.
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing
Journal of Clinical Investigation 124 (8): 3419-3430 (2014-08-01)



Adachi S.; Murakawa Y.; Hiraga S.
SecA defects are accompanied by dysregulation of MukB, DNA gyrase, chromosome partitioning and DNA superhelicity in Escherichia coli
Microbiology 160 (Pt 8): 1648-1658 (2014-08)



Gregersen L.H.; Schueler M.; Munschauer M.; Mastrobuoni G.; Chen W.; Kempa S.; Dieterich C.; Landthaler M.
MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs
Molecular Cell 54 (4): 573-585 (2014-05-22)



Spitzer J.; Hafner M.; Landthaler M.; Ascano M.; Farazi T.; Wardle G.; Nusbaum J.; Khorshid M.; Burger L.; Zavolan M.; Tuschl T.
PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins
Methods in Enzymology 539: 113-161 (2014-02-25)



Munschauer M.; Schueler M.; Dieterich C.; Landthaler M.
High-resolution profiling of protein occupancy on polyadenylated RNA transcripts
Methods 65 (3): 302-309 (2014-02)



Schueler M.; Munschauer M.; Gregersen L.H.; Finzel A.; Loewer A.; Chen W.; Landthaler M.; Dieterich C.
Differential protein occupancy profiling of the mRNA transcriptome
Genome Biology 15 (1): R15 (2014-01-13)



2013

Wang Y.; Gogol-Doering A.; Hu H.; Froehler S.; Ma Y.; Jens M.; Maaskola J.; Murakawa Y.; Quedenau C.; Landthaler M.; Kalscheuer V.; Wieczorek D.; Wang Y.; Hu Y.; Chen W.
Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation
EMBO Molecular Medicine 5 (9): 1431-1442 (2013-09)



Graf R.; Munschauer M.; Mastrobuoni G.; Mayr F.; Heinemann U.; Kempa S.; Rajewsky N.; Landthaler M.
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
RNA Biology 10 (7): 1146-1159 (2013-07-01)



Shum D.; Bhinder B.; Ramirez C.N.; Radu C.; Calder P.A.; Beauchamp L.; Farazi T.; Landthaler M.; Tuschl T.; Magdaleno S.; Djaballah H.
An arrayed RNA interference genome-wide screen identifies candidate genes involved in the MicroRNA 21 biogenesis pathway
Assay and Drug Development Technologies 11 (3): 191-205 (2013-04)



Memczak S.; Jens M.; Elefsinioti A.; Torti F.; Krueger J.; Rybak A.; Maier L.; Mackowiak S.D.; Gregersen L.H.; Munschauer M.; Loewer A.; Ziebold U.; Landthaler M.; Kocks C.; le Noble F.; Rajewsky N.
Circular RNAs are a large class of animal RNAs with regulatory potency
Nature 495 (7441): 333-338 (2013-03-21)



Liu Y.; Hu W.; Murakawa Y.; Yin J.; Wang G.; Landthaler M.; Yan J.
Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation
Scientific Reports 3: 2054 (2013)



Spitzer J.; Landthaler M.; Tuschl T.
Rapid creation of stable mammalian cell lines for regulated expression of proteins using the Gateway(R) recombination cloning technology and Flp-In T-REx(R) lines
Methods in Enzymology 529: 99-124 (2013)



2012

Shum D.; Bhinder B.; Radu C.; Farazi T.; Landthaler M.; Tuschl T.; Calder P.; Ramirez C.N.; Djaballah H.
An image-based biosensor assay strategy to screen for modulators of the microRNA 21 biogenesis pathway
Combinatorial Chemistry & High Throughput Screening 15 (7): 529-541 (2012-08)



Gregersen L.H.; Jacobsen A.; Frankel L.B.; Wen J.; Krogh A.; Lund A.H.
MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells
BMC Cancer 12: 232 (2012-06-12)



Baltz A.G.; Munschauer M.; Schwanhaeusser B.; Vasile A.; Murakawa Y.; Schueler M.; Youngs N.; Penfold-Brown D.; Drew K.; Milek M.; Wyler E.; Bonneau R.; Selbach M.; Dieterich C.; Landthaler M.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
Molecular Cell 46 (5): 674-690 (2012-06-08)



Milek M.; Wyler E.; Landthaler M.
Transcriptome-wide analysis of protein-RNA interactions using high-throughput sequencing
Seminars in Cell & Developmental Biology 23 (2): 206-212 (2012-04)



Anders G.; Mackowiak S.D.; Jens M.; Maaskola J.; Kuntzagk A.; Rajewsky N.; Landthaler M.; Dieterich C.
doRiNA: a database of RNA interactions in post-transcriptional regulation
Nucleic Acids Research 40 (1): D180-D186 (2012-01)



2011

Lebedeva S.; Jens M.; Theil K.; Schwanhaeusser B.; Selbach M.; Landthaler M.; Rajewsky N.
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
Molecular Cell 43 (3): 340-352 (2011-08-05)



Zhang X.; Yalcin S.; Lee D.F.; Yeh T.Y.; Lee S.M.; Su J.; Mungamuri S.K.; Rimmele P.; Kennedy M.; Sellers R.; Landthaler M.; Tuschl T.; Chi N.W.; Lemischka I.; Keller G.; Ghaffari S.
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
Nature Cell Biology 13 (9): 1092-1099 (2011-07-31)



Ohrt T.; Staroske W.; Muetze J.; Crell K.; Landthaler M.; Schwille P.
Fluorescence cross-correlation spectroscopy reveals mechanistic insights into the effect of 2'-O-methyl modified siRNAs in living cells
Biophysical Journal 100 (12): 2981-2990 (2011-06-22)



2010

Landthaler M.
Chaperones get RISC loaded
Molecular Cell 39 (2): 161-162 (2010-07-30)



Hafner M.; Landthaler M.; Burger L.; Khorshid M.; Hausser J.; Berninger P.; Rothballer A.; Ascano M.; Jungkamp A.C.; Munschauer M.; Ulrich A.; Wardle G.S.; Dewell S.; Zavolan M.; Tuschl T.
PAR-CliP - a method to identify transcriptome-wide the binding sites of RNA binding proteins
Journal of Visualized Experiments 41 (2034): e2034 (2010-07-02)



Hafner M.; Landthaler M.; Burger L.; Khorshid M.; Hausser J.; Berninger P.; Rothballer A.; Ascano M.; Jungkamp A.C.; Munschauer M.; Ulrich A.; Wardle G.S.; Dewell S.; Zavolan M.; Tuschl T.
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
Cell 141 (1): 129-141 (2010-04-02)



2009

Hausser J.; Landthaler M.; Jaskiewicz L.; Gaidatzis D.; Zavolan M.
Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets
Genome Research 19 (11): 2009-2020 (2009-11)



Zhang Y.; Landthaler M.; Schlussman S.D.; Yuferov V.; Ho A.; Tuschl T.; Kreek M.J.
Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin
Neuroscience 158 (2): 474-483 (2009-01-23)



Yi R.; Pasolli H.A.; Landthaler M.; Hafner M.; Ojo T.; Sheridan R.; Sander C.; O'Carroll D.; Stoffel M.; Tuschl T.; Fuchs E.
DGCR8-dependent microRNA biogenesis is essential for skin development
Proceedings of the National Academy of Sciences of the United States of America 106 (2): 498-502 (2009-01-13)



2008

Landthaler M.; Gaidatzis D.; Rothballer A.; Chen P.Y.; Soll S.J.; Dinic L.; Ojo T.; Hafner M.; Zavolan M.; Tuschl T.
Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs
RNA 14 (12): 2580-2596 (2008-12)



2007

Randall G.; Panis M.; Cooper J.D.; Tellinghuisen T.L.; Sukhodolets K.E.; Pfeffer S.; Landthaler M.; Landgraf P.; Kan S.; Lindenbach B.D.; Chien M.; Weir D.B.; Russo J.J.; Ju J.; Brownstein M.J.; Sheridan R.; Sander C.; Zavolan M.; Tuschl T.; Rice C.M.
Cellular cofactors affecting hepatitis C virus infection and replication
Proceedings of the National Academy of Sciences of the United States of America 104 (31): 12884-12889 (2007-07-31)



Landgraf P.; Rusu M.; Sheridan R.; Sewer A.; Iovino N.; Aravin A.; Pfeffer S.; Rice A.; Kamphorst A.O.; Landthaler M.; Lin C.; Socci N.D.; Hermida L.; Fulci V.; Chiaretti S.; Foa R.; Schliwka J.; Fuchs U.; Novosel A.; Mueller R.U.; Schermer B.; Bissels U.; Inman J.; Phan Q.; Chien M.; Weir D.B.; Choksi R.; De Vita G.; Frezzetti D.; Trompeter H.I.; Hornung V.; Teng G.; Hartmann G.; Palkovits M.; Di Lauro R.; Wernet P.; Macino G.; Rogler C.E.; Nagle J.W.; Ju J.; Papavasiliou F.N.; Benzing T.; Lichter P.; Tam W.; Brownstein M.J.; Bosio A.; Borkhardt A.; Russo J.J.; Sander C.; Zavolan M.; Tuschl T.
A mammalian microRNA expression atlas based on small RNA library sequencing
Cell 129 (7): 1401-1414 (2007-06-29)



2006

Hickerson R.P.; Smith F.J.D.; McLean W.H.I.; Landthaler M.; Leube R.E.; Kaspar R.L.
SiRNA-mediated selective inhibition of mutant keratin mRNAs responsible for the skin disorder pachyonychia congenita
Annals of the New York Academy of Sciences 1082: 56-61 (2006-10)



Landthaler M.; Shen B.W.; Stoddard B.L.; Shub D.A.
I-BasI and I-HmuI: two phage intron-encoded endonucleases with homologous DNA recognition sequences but distinct DNA specificities
Journal of Molecular Biology 358 (4): 1137-1151 (2006-05-12)



2005

Meister G.; Landthaler M.; Peters L.; Chen P.Y.; Urlaub H.; Luehrmann R.; Tuschl T.
Identification of novel argonaute-associated proteins
Current Biology 15 (23): 2149-2155 (2005-12-06)



Coros C.J.; Landthaler M.; Piazza C.L.; Beauregard A.; Esposito D.; Perutka J.; Lambowitz A.M.; Belfort M.
Retrotransposition strategies of the Lactococcus lactis Ll.LtrB group II intron are dictated by host identity and cellular environment
Molecular Microbiology 56 (2): 509-524 (2005-04)



Paludan C.; Schmid D.; Landthaler M.; Vockerodt M.; Kube D.; Tuschl T.; Muenz C.
Endogenous MHC class II processing of a viral nuclear antigen after autophagy
Science 307 (5709): 593-596 (2005-01-28)



2004

Landthaler M.; Yalcin A.; Tuschl T.
The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis
Current Biology 14 (23): 2162-2167 (2004-12-14)



Shen B.W.; Landthaler M.; Shub D.A.; Stoddard B.L.
DNA binding and cleavage by the HNH homing endonuclease I-HmuI
Journal of Molecular Biology 342 (1): 43-56 (2004-09-03)



Meister G.; Landthaler M.; Patkaniowska A.; Dorsett Y.; Teng G.; Tuschl T.
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
Molecular Cell 15 (2): 185-197 (2004-07-23)



Landthaler M.; Lau N.C.; Shub D.A.
Group I intron homing in Bacillus phages SPO1 and SP82: a gene conversion event initiated by a nicking homing endonuclease
Journal of Bacteriology 186 (13): 4307-4314 (2004-07)



Meister G.; Landthaler M.; Dorsett Y.; Tuschl T.
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
RNA 10 (3): 544-550 (2004-03)



2003

Landthaler M.; Shub D.A.
The nicking homing endonuclease I-BasI is encoded by a group I intron in the DNA polymerase gene of the Bacillus thuringiensis phage Bastille
Nucleic Acids Research 31 (12): 3071-3077 (2003-06-15)



2002

Belle A.; Landthaler M.; Shub D.A.
Intronless homing: site-specific endonuclease SegF of bacteriophage T4 mediates localized marker exclusion analogous to homing endonucleases of group I introns
Genes & Development 16 (3): 351-362 (2002)



Landthaler M.; Begley U.; Lau N.C.; Shub D.A.
Two self-splicing group I introns in the ribonucleotide reductase large subunit gene of Staphylococcus aureus phage Twort
Nucleic Acids Research 30 (9): 1935-1943 (2002)



1999

Landthaler M.; Shub D.A.
Unexpected abundance of self-splicing introns in the genome of bacteriophage Twort: introns in multiple genes, a single gene with three introns, and exon skipping by group I ribozymes
Proceedings of the National Academy of Sciences of the United States of America 96 (12): 7005-7010 (1999-06-08)