Achim Leutz

Max-Delbrück-Center for Molecular Medicine (MDC)

Robert-Rössle-Str. 10

13125 Berlin, Germany

House 31.1, room 4028

Phone: +49 30 9406 3735

Fax: +49 30 9406 3298

aleutz [at] mdc-berlin.de

www.mdc-berlin.de/leutz

 

Secretary:

Sylvia Sibilak

House 31.1, Room 4029

Phone: +49 30 9406 3349

Fax: +49 30 9406 3298

Sibilak [at] mdc-berlin.de

 

Cell Differentiation and Tumorigenesis

Hematopoietic stem cells in the bone marrow sustain their own maintenance and give rise to “transit amplifying”, lineage committed cells that terminally differentiate into at least 8 different short-lived cell types. Hematopoietic transcription factors concertedly control cell amplification, commitment, and differentiation. Mutations in these key transcription factors dysregulate hematopoiesis and cause diseases such as leukemia, anemia, or immune defects. A major task in experimental hematology, leukemia research, and stem cell research is to untangle the underlying transcription factor network, disclose functional interactions between its components,  understand how they regulate genes and chromatin, and thereby reveal novel therapeutic targets.

Major interests of the lab are the function of transcription factors of the CCAAT Enhancer Binding Protein family (C/EBPs), Myb, and Tal1/Scl during gene regulation and chromatin remodeling, and signaling events that mediate transcription factor regulation (C/EBP, Myb, Tal1/Scl, WNT-b,g-catenin/LEF).  We use state-of-the-art molecular genetics and targeted mouse genetics to unravel onco-developmental processes connected to these transcription factors.

 

Publications

Smink JJ; Begay V; Schoenmaker T; Sterneck E; de Vries TJ; Leutz A: Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO Journal 28 (12): 1769-1781 (2009-06-17)

 

Broeske AM; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SE; Rosenbauer F: DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nature Genetics : (2009-10-04)

 

Pless O; Kowenz-Leutz E; Knoblich M; Lausen J; Beyerman M; Walsh MJ; Leutz A: G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. Journal of Biological Chemistry 283 (39): 26357-26363 (2008-09-26)

 

Jeannet G; Scheller M; Scarpellino L; Duboux S; Gardiol N; Back J; Kuttler F; Malanchi I; Birchmeier W; Leutz A; Huelsken J; Held W: Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin. Blood 111 (1): 142-149 (2008-01-01)

 

Simmons DG; Natale DR; Begay V; Hughes M; Leutz A; Cross JC: Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth. Development 135 (12): 2083-2091 (2008-06)

 

Chen Y; Xu H; Liu J; Zhang C; Leutz A; Mo X: The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells. Biochemical and Biophysical Research Communications 360 (2): 433-436 (2007-08-24)

 

Scheller M; Huelsken J; Rosenbauer F; Taketo MM; Birchmeier W; Tenen DG; Leutz A: Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nature Immunology 7 (10): 1037-1047 (2006-10)

 

Wiesenthal V; Leutz A; Calkhoven CF: Analysis of translation initiation using a translation control reporter system. Nature Protocols 1 (3): 1531-1537 (2006-11-09)

 

Wiesenthal V; Leutz A; Calkhoven CF: A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell. Nucleic Acids Research 34 (3): e23 (2006-02-10)

 

Rosenbauer F; Owens BM; Yu L; Tumang JR; Steidl U; Kutok JL; Clayton LK; Wagner K; Scheller M; Iwasaki H; Liu C; Hackanson B; Akashi K; Leutz A; Rothstein TL; Plass C; Tenen DG: Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nature Genetics 38 (1): 27-37 (2006-01)