Publications



2017

Griger J.; Schneider R.; Lahmann I.; Schoewel V.; Keller C.; Spuler S.; Nazare M.; Birchmeier C.
Loss of Ptpn11 (Shp2) drives satellite cells into quiescence
eLife 6: e21552 (2017-05-02)



Kufeld M.; Escobar H.; Marg A.; Pasemann D.; Budach V.; Spuler S.
Localized irradiation of mouse legs using an image-guided robotic linear accelerator
Annals of Translational Medicine 5 (7): 156 (2017-04)



2016

Bhattarai S.; Ghannam K.; Krause S.; Benveniste O.; Marg A.; de Bruin G.; Xin B.T.; Overkleeft H.S.; Spuler S.; Stenzel W.; Feist E.
The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies
Journal of Autoimmunity 75: 118-129 (2016-12)



Ziat E.; Mamchaoui K.; Beuvin M.; Nelson I.; Azibani F.; Spuler S.; Bonne G.; Bertrand A.T.
FHL1B Interacts with lamin A/C and emerin at the nuclear lamina and is misregulated in Emery-Dreifuss Muscular Dystrophy
Journal of Neuromuscular Diseases 3 (4): 497-510 (2016-11-29)



Harris E.; Bladen C.L.; Mayhew A.; James M.; Bettinson K.; Moore U.; Smith F.E.; Rufibach L.; Cnaan A.; Bharucha-Goebel D.X.; Blamire A.M.; Bravver E.; Carlier P.G.; Day J.W.; Diaz-Manera J.; Eagle M.; Grieben U.; Harms M.; Jones K.J.; Lochmueller H.; Mendell J.R.; Mori-Yoshimura M.; Paradas C.; Pegoraro E.; Pestronk A.; Salort-Campana E.; Schreiber-Katz O.; Semplicini C.; Spuler S.; Stojkovic T.; Straub V.; Takeda S.; Rocha C.T.; Walter M.C.; Bushby K.
The clinical outcome study for dysferlinopathy: an international multicenter study
Neurology Genetics 2 (4): e89 (2016-08-04)



Schmacht L.; Traber J.; Grieben U.; Utz W.; Dieringer M.A.; Kellman P.; Blaszczyk E.; von Knobelsdorff-Brenkenhoff F.; Spuler S.; Schulz-Menger J.
Cardiac involvement in myotonic dystrophy type 2 patients with preserved ejection fraction: Detection by cardiovascular magnetic resonance
Circulation Cardiovascular Imaging 9 (7): e004615 (2016-07)



Moshourab R.; Palada V.; Grunwald S.; Grieben U.; Lewin G.R.; Spuler S.
A molecular signature of myalgia in myotonic dystrophy 2
EBioMedicine 7: 205-211 (2016-05)



Escobar H.; Schoewel V.; Spuler S.; Marg A.; Izsvak Z.
Full-length dysferlin transfer by the hyperactive Sleeping Beauty transposase restores dysferlin-deficient muscle
Molecular Therapy - Nucleic Acids 5: e277 (2016-01-19)



2015

Philippi S.; Lorain S.; Beley C.; Peccate C.; Precigout G.; Spuler S.; Garcia L.
Dysferlin rescue by spliceosome-mediated pre-mRNA trans-splicing targeting introns harbouring weakly defined 3' splice sites
Human Molecular Genetics 24 (14): 4049-4060 (2015-07-15)



Timmel T.; Kunz S.; Seifert F.; Schuelke M.; Spuler S.
Cavin 1 function does not follow caveolar morphology
American Journal of Physiology Cell Physiology 308 (12): C1023-C1030 (2015-06-15)



Horbelt D.; Boergermann J.H.; Chaikuad A.; Alfano I.; Williams E.; Lukonin I.; Timmel T.; Bullock A.N.; Knaus P.
Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation
Journal of Biological Chemistry 290 (6): 3390-3404 (2015-02-06)



2014

Marg A.; Escobar H.; Gloy S.; Kufeld M.; Zacher J.; Spuler A.; Birchmeier C.; Izsvak Z.; Spuler S.
Human satellite cells have regenerative capacity and are genetically manipulable
Journal of Clinical Investigation 124 (10): 4257-4265 (2014-10-01)



Koch S.; Wollersheim T.; Bierbrauer J.; Haas K.; Moergeli R.; Deja M.; Spies C.D.; Spuler S.; Krebs M.; Weber-Carstens S.
Long term recovery in critical illness myopathy is complete, contrary to polyneuropathy
Muscle & Nerve 50 (3): 431-436 (2014-09)



Grounds M.D.; Terrill J.; Radley-Crabb H.; Robertson T.; Papadimitriou J.; Spuler S.; Shavlakadze T.
Lipid accumulation in dysferlin-deficient muscles
American Journal of Pathology 184 (6): 1668-1676 (2014-06)



Timmel T.; Schuelke M.; Spuler S.
Identifying dynamic membrane structures with atomic-force microscopy and confocal imaging
Microscopy and Microanalysis 20 (2): 514-520 (2014-04)



Langhans C.; Weber-Carstens S.; Schmidt F.; Hamati J.; Kny M.; Zhu X.; Wollersheim T.; Koch S.; Krebs M.; Schulz H.; Lodka D.; Saar K.; Labeit S.; Spies C.; Hubner N.; Spranger J.; Spuler S.; Boschmann M.; Dittmar G.; Butler-Browne G.; Mouly V.; Fielitz J.
Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy
PLoS ONE 9 (3): e92048 (2014-03-20)



Wollersheim T.; Woehlecke J.; Krebs M.; Hamati J.; Lodka D.; Luther-Schroeder A.; Langhans C.; Haas K.; Radtke T.; Kleber C.; Spies C.; Labeit S.; Schuelke M.; Spuler S.; Spranger J.; Weber-Carstens S.; Fielitz J.
Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness
Intensive Care Medicine 40 (4): 528-538 (2014-02-15)



2013

Pakula A.; Schneider J.; Janke J.; Zacharias U.; Schulz H.; Huebner N.; Maehler A.; Spuler A.; Spuler S.; Carlier P.; Boschmann M.
Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1)
PLoS ONE 8 (9): e73573 (2013-09-03)



Raith M.; Valencia R.G.; Fischer I.; Orthofer M.; Penninger J.M.; Spuler S.; Rezniczek G.A.; Wiche G.
Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers
Skeletal Muscle 3 (1): 14 (2013-06-12)



Weber-Carstens S.; Schneider J.; Wollersheim T.; Assmann A.; Bierbrauer J.; Marg A.; Al Hasani H.; Chadt A.; Wenzel K.; Koch S.; Fielitz J.; Kleber C.; Faust K.; Mai K.; Spies C.D.; Luft F.C.; Boschmann M.; Spranger J.; Spuler S.
Critical illness myopathy and GLUT4 - significance of insulin and muscle contraction
American Journal of Respiratory and Critical Care Medicine 187 (4): 387-396 (2013-02-15)



2012

Schoewel V.; Marg A.; Kunz S.; Overkamp T.; Siegert Carrazedo R.; Zacharias U.; Daniel P.T.; Spuler S.
Dysferlin-peptides reallocate mutated dysferlin thereby restoring function
PLoS ONE 7 (11): e49603 (2012-11-20)



Marg A.; Schoewel V.; Timmel T.; Schulze A.; Shah C.; Daumke O.; Spuler S.
Sarcolemmal repair is a slow process and includes EHD2
Traffic 13 (9): 1286-1294 (2012-09)



Hennermann J.B.; Berger J.M.; Grieben U.; Scharer G.; Van Hove J.L.K.
Prediction of long-term outcome in glycine encephalopathy: a clinical survey
Journal of Inherited Metabolic Disease 35 (2): 253-61 (2012-03)



Philippi S.; Bigot A.; Marg A.; Mouly V.; Spuler S.; Zacharias U.
Dysferlin-deficient immortalized human myoblasts and myotubes as a useful tool to study dysferlinopathy
PLoS Currents 4: RRN1298 (2012-02-28)



Bierbrauer J.; Koch S.; Olbricht C.; Hamati J.; Lodka D.; Schneider J.; Luther-Schroeder A.; Kleber C.; Faust K.; Wiesener S.; Spies C.D.; Spranger J.; Spuler S.; Fielitz J.; Weber-Carstens S.
Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane
Critical Care Medicine 40 (2): 647-650 (2012-02)



2011

Zacharias U.; Purfuerst B.; Schoewel V.; Morano I.; Spuler S.; Haase H.
Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release
Journal of Muscle Research and Cell Motility 32 (4-5): 271-280 (2011-12)



Mamchaoui K.; Trollet C.; Bigot A.; Negroni E.; Chaouch S.; Wolff A.; Kandalla P.K.; Marie S.; Di Santo J.; St Guily J.L.; Muntoni F.; Kim J.; Philippi S.; Spuler S.; Levy N.; Blumen S.C.; Voit T.; Wright W.E.; Aamiri A.; Butler-Browne G.; Mouly V.
Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders
Skeletal Muscle 1 (1): 34 (2011-11-01)



Antunes F.; Marg A.; Vinkemeier U.
STAT1 signaling is not regulated by a phosphorylation-acetylation switch
Molecular and Cellular Biology 31 (14): 3029-3037 (2011-07)



Droescher M.; Begitt A.; Marg A.; Zacharias M.; Vinkemeier U.
Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO)
Journal of Biological Chemistry 286 (21): 18731-18746 (2011-05-27)



Spuler S.; Stroux A.; Kuschel F.; Kuhlmey A.; Kendel F.
Delay in diagnosis of muscle disorders depends on the subspecialty of the initially consulted physician
BMC Health Services Research 11: 91 (2011-05-04)



Koch S.; Spuler S.; Deja M.; Bierbrauer J.; Dimroth A.; Behse F.; Spies C.D.; Wernecke K.D.; Weber-Carstens S.
Critical illness myopathy is frequent: accompanying neuropathy protracts ICU discharge
Journal of Neurology Neurosurgery and Psychiatry 82 (3): 287-293 (2011-03)



Biedasek K.; Andres J.; Mai K.; Adams S.; Spuler S.; Fielitz J.; Spranger J.
Skeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF-1
PLoS ONE 6 (1): e16674 (2011-01-31)



2010

Deuschl G.; Margraf N.; Spuler S.; Kupsch A.; Schulz-Schaeffer W.J.
Camptocormia and myopathy
Movement Disorders 25 (15): 2689-2690 (2010-11-15)



de Greef J.C.; Lemmers R.J.; Camano P.; Day J.W.; Sacconi S.; Dunand M.; van Engelen B.G.; Kiuru-Enari S.; Padberg G.W.; Rosa A.L.; Desnuelle C.; Spuler S.; Tarnopolsky M.; Venance S.L.; Frants R.R.; van der Maarel S.M.; Tawil R.
Clinical features of facioscapulohumeral muscular dystrophy 2
Neurology 75 (17): 1548-1554 (2010-10-26)



Weber-Carstens S.; Deja M.; Koch S.; Spranger J.; Bubser F.; Wernecke K.D.; Spies C.D.; Spuler S.; Keh D.
Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study
Critical Care 14 (3): R119 (2010-06-18)



Spuler S.; Krug H.; Klein C.; Medialdea I.C.; Jakob W.; Ebersbach G.; Gruber D.; Hoffmann K.T.; Trottenberg T.; Kupsch A.
Myopathy causing camptocormia in idiopathic Parkinson's disease: a multidisciplinary approach
Movement Disorders 25 (5): 552-559 (2010-04-15)



Knoblauch H.; Schoewel V.; Kress W.; Rosada A.; Spuler S.
Another side to statin-related side effects
Annals of Internal Medicine 152 (7): 478-479 (2010-04-06)



Boschmann M.; Engeli S.; Moro C.; Luedtke A.; Adams F.; Gorzelniak K.; Rahn G.; Maehler A.; Dobberstein K.; Krueger A.; Schmidt S.; Spuler S.; Luft F.C.; Smith S.R.; Schmidt H.H.; Jordan J.
LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance
Journal of Clinical Endocrinology and Metabolism 95 (4): 1634-1643 (2010-04)



Rajab A.; Straub V.; McCann L.J.; Seelow D.; Varon R.; Barresi R.; Schulze A.; Lucke B.; Luetzkendorf S.; Karbasiyan M.; Bachmann S.; Spuler S.; Schuelke M.
Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations
PLoS Genetics 6 (3): e1000874 (2010-03-12)



Utz W.; Schmidt S.; Schulz-Menger J.; Luft F.; Spuler S.
Cardiac involvement in sporadic inclusion-body myositis
Circulation 121 (5): 706-708 (2010-02-09)



Knoblauch H.; Geier C.; Adams S.; Budde B.; Rudolph A.; Zacharias U.; Schulz-Menger J.; Spuler A.; Yaou R.B.; Nuernberg P.; Voit T.; Bonne G.; Spuler S.
Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation
Annals of Neurology 67 (1): 136-140 (2010-01)



2009

Gueneau L.; Bertrand A.T.; Jais J.P.; Salih M.A.; Stojkovic T.; Wehnert M.; Hoeltzenbein M.; Spuler S.; Saitoh S.; Verschueren A.; Tranchant C.; Beuvin M.; Lacene E.; Romero N.B.; Heath S.; Zelenika D.; Voit T.; Eymard B.; Ben Yaou R.; Bonne G.
Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy
American Journal of Human Genetics 85 (3): 338-353 (2009-09)



Weber-Carstens S.; Koch S.; Spuler S.; Spies C.D.; Bubser F.; Wernecke K.D.; Deja M.
Nonexcitable muscle membrane predicts intensive care unit-acquired paresis in mechanically ventilated, sedated patients
Critical Care Medicine 37 (9): 2632-2637 (2009-09)



Mai K.; Andres J.; Biedasek K.; Weicht J.; Bobbert T.; Sabath M.; Meinus S.; Reinecke F.; Moehlig M.; Weickert M.O.; Clemenz M.; Pfeiffer A.F.; Kintscher U.; Spuler S.; Spranger J.
Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
Diabetes 58 (7): 1532-1538 (2009-07)



Carl M.; Roecken C.; Spuler S.
Amyloidose bei Muskeldystrophie [Amyloidosis in muscular dystrophy]
Pathologe 30 (3): 235-239 (2009-05)



Schmidt S.; Vieweger A.; Obst M.; Mueller S.; Gross V.; Gutberlet M.; Steinbrink J.; Taubert S.; Misselwitz B.; Luedemann L.; Spuler S.
Dysferlin-deficient muscular dystrophy: Gadofluorine M suitability at MR imaging in a mouse model
Radiology 250 (1): 87-94 (2009-01)



2008

Geier C.; Gehmlich K.; Ehler E.; Hassfeld S.; Perrot A.; Hayess K.; Cardim N.; Wenzel K.; Erdmann B.; Krackhardt F.; Posch M.G.; Bublak A.; Naegele H.; Scheffold T.; Dietz R.; Chien K.R.; Spuler S.; Fuerst D.O.; Nuernberg P.; Oezcelik C.
Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy
Human Molecular Genetics 17 (18): 2753-2765 (2008-09-15)



Spuler S.; Carl M.; Zabojszcza J.; Straub V.; Bushby K.; Moore S.A.; Baehring S.; Wenzel K.; Vinkemeier U.; Rocken C.
Dysferlin-deficient muscular dystrophy features amyloidosis
Annals of Neurology 63 (3): 323-328 (2008-03)



Meyer T.; Jurkat-Rott K.; Huebner A.; Lehmann-Horn F.; Linke P.; Van Landeghem F.; Dullinger J.S.; Spuler S.
Progressive muscle atrophy with hypokalemic periodic paralysis and calcium channel mutation
Muscle & nerv 37 (1): 120-124 (2008-01)



2007

Wenzel K.; Geier C.; Qadri F.; Huebner N.; Schulz H.; Erdmann B.; Gross V.; Bauer D.; Dechend R.; Dietz R.; Osterziel K.J.; Spuler S.; Oezcelik C.
Dysfunction of dysferlin-deficient hearts
Journal of Molecular Medicine 85 (11): 1203-1214 (2007-11)



Luedtke A.; Buettner J.; Wu W.; Muchir A.; Schroeter A.; Zinn-Justin S.; Spuler S.; Schmidt H.H.; Worman H.J.
Peroxisome proliferator-activated receptor-gamma C190S mutation causes partial lipodystrophy
Journal of Clinical Endocrinology and Metabolism 92 (6): 2248-2255 (2007-06)



Spuler S.; Kalbhenn T.; Zabojszcza J.; van Landeghem F.K.; Ludtke A.; Wenzel K.; Koehnlein M.; Schuelke M.; Luedemann L.; Schmidt H.H.
Muscle and nerve pathology in Dunnigan familial partial lipodystrophy
Neurology 68 (9): 677-683 (2007-02-27)



Diers A.; Carl M.; Stoltenburg-Didinger G.; Vorgerd M.; Spuler S.
Painful enlargement of the calf muscles in limb girdle muscular dystrophy type 2B (LGMD2B) with a novel compound heterozygous mutation in DYSF
Neuromuscular Disorders 17 (2): 157-162 (2007-02)



2006

Roecken C.; Ernst J.; Hund E.; Michels H.; Perz J.; Saeger W.; Sezer O.; Spuler S.; Willig F.; Schmidt H.H.
Interdisziplinaere Leitlinien zur Diagnostik und Therapie der extrazerebralen Amyloidosen: Herausgegeben von der Deutschen Gesellschaft fuer Amyloid-Krankheiten e. V. (www.amyloid.de) [Interdisciplinary guidelines for diagnosis and therapy of extracerebral amyloidosis: issued by the German Society of Amyloid Diseases e. V. (www.amyloid.de)]
Medizinische Klinik 101 (10): 825-829 (2006-10-15)



Röcken C.; Ernst J.; Hund E.; Michels H.; Perz J.; Saeger W.; Sezer O.; Spuler S.; Willig F.; Schmidt H.H.
Interdisziplinaere Leitlinien zur Diagnostik und Therapie der extrazerebralen Amyloidosen -- Herausgegeben von der Deutschen Gesellschaft fuer Amyloid-Krankheiten e.V. (www.amyloid.de) [Interdisciplinary guidelines on diagnosis and treatment for extracerebral amyloidoses--published by the German Society of Amyloid Diseases (www.amyloid.de)]
Deutsche Medizinische Wochenschrift 131 (27 Suppl 2): S45-S66 (2006-07-07)



Wenzel K.; Carl M.; Perrot A.; Zabojszcza J.; Assadi M.; Ebeling M.; Geier C.; Robinson P.N.; Kress W.; Osterziel K.J.; Spuler S.
Novel sequence variants in dysferlin-deficient muscular dystrophy leading to mRNA decay and possible C2-domain misfolding
Human Mutation 27: 599-600 (2006-06)



2005

Luedtke A.; Heck K.; Genschel J.; Mehnert H.; Spuler S.; Worman H.J.; Schmidt H.H.
Long-term treatment experience in a subject with Dunnigan-type familial partial lipodystrophy: efficacy of rosiglitazone
Diabetic Medicine 22 (11): 1611-1613 (2005-11)



Wenzel K.; Zabojszcza J.; Carl M.; Taubert S.; Lass A.; Harris C.L.; Ho M.; Schulz H.; Hummel O.; Huebner N.; Osterziel K.J.; Spuler S.
Increased susceptibility to complement attack due to down-regulation of decay-accelerating factor/CD55 in dysferlin-deficient muscular dystrophy
Journal of Immunology 175 (9): 6219-6225 (2005-11-01)



Spuler S.; Geier C.; Osterziel K.J.; Gutberlet M.; Genschel J.; Lehmann T.N.; Zinn-Justin S.; Gilquin B.; Schmidt H.
A new LMNA mutation causing limb girdle muscular dystrophy 1B
Journal of Neurology 252 (5): 621-623 (2005-05)



Perrot A.; Spuler S.; Geier C.; Dietz R.; Osterziel K.J.
Kardiale Manifestationen bei Muskeldystrophien [Cardiac manifestations of muscular dystrophies]
Zeitschrift fuer Kardiologie 94: 312-320 (2005-01-01)



2004

Spuler S.; Lehmann T.N.; Engel A.G.
Differenzialdiagnostik eines kongenitalen myasthenen Syndroms [Differential congenital myasthenia syndrome diagnosis]
Nervenarzt 75 (2): 141-144 (2004-02)



1999

Padberg F.; Matsuda M.; Fenk R.; Patenge N.; Kubuschok B.; Hohlfeld R.; Wekerle H.; Spuler S.
Myasthenia gravis: selective enrichment of antiacetylcholine receptor antibody production in untransformed human B cell cultures
European Journal of Immunology 29 (11): 3538-3548 (1999-11)



Eisensehr I.; Buettner U.; Witt T.N.; von Appen K.; Spuler S.
Myasthenia gravis: Opportunistische Zytomegalievirus-Infektion nach langzeitiger Azathioprin-Therapie [Myasthenia gravis. Opportunistic cytomegalovirus infection after long-term azathioprine therapy]
Nervenarzt 70 (10): 924-926 (1999-10)



1998

Spuler S.; Emslie-Smith A.; Engel A.G.
Amyloid myopathy: an underdiagnosed entity
Annals of Neurology 43 (6): 719-728 (1998-06)



Spuler S.; Engel A.G.
Unexpected sarcolemmal complement membrane attack complex deposits on nonnecrotic muscle fibers in muscular dystrophies
Neurology 50 (1): 41-46 (1998-01-01)



1997

Voltz R.; Kamm C.; Padberg F.; Malotka J.; Kerschensteiner M.; Spuler S.; Tzartos S.; Dornmair K.
Highly purified oligo-His tagged human recombinant alpha(1)-AChR is immunogenic in vivo and suitable for T cell stimulation in vitro in experimental and human myasthenia gravis
Journal of Neuroimmunology 80 (1-2): 131-136 (1997-12)



Spuler S.; Engel A.G.
SMI-31 immunoreactivity in inclusion body myositis
Annals of Neurology 42 (5): 815 (1997-11)



Voltz R.; Hartmann M.; Spuler S.; Scheller A.; Mai N.; Hohlfeld R.; Yousry T.
Multiple sclerosis: longitudinal measurement of interleukin-1 receptor antagonist
Journal of Neurology Neurosurgery and Psychiatry 62 (2): 200-201 (1997-02)



1996

Filippi M.; Yousry T.; Baratti C.; Horsfield M.A.; Mammi S.; Becker C.; Voltz R.; Spuler S.; Campi A.; Reiser M.F.; Comi G.
Quantitative assessment of MRI lesion load in multiple sclerosis. A comparison of conventional spin-echo with fast fluid-attenuated inversion recovery
Brain 119 (4): 1349-1355 (1996-08)



Spuler S.; Sarropoulos A.; Marx A.; Hohlfeld R.; Wekerle H.
Thymoma-associated myasthenia gravis. Transplantation of thymoma and extrathymomal thymic tissue into SCID mice
American Journal of Pathology 148 (5): 1359-1365 (1996-05)



Spuler S.; Yousry T.; Scheller A.; Voltz R.; Holler E.; Hartmann M.; Wick M.; Hohlfeld R.
Multiple sclerosis: prospective analysis of TNF-alpha and 55 kDa TNF receptor in CSF and serum in correlation with clinical and MRI activity
Journal of Neuroimmunology 66 (1-2): 57-64 (1996-05)



Filippi M.; Yousry T.; Campi A.; Kandziora C.; Colombo B.; Voltz R.; Martinelli V.; Spuler S.; Bressi S.; Scotti G.; Comi G.
Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with MS
Neurology 46 (2): 379-384 (1996-02)



1995

Hohlfeld R.; Meinl E.; Weber F.; Zipp F.; Schmidt S.; Sotgiu S.; Goebels N.; Voltz R.; Spuler S.; Iglesias A.
The role of autoimmune T lymphocytes in the pathogenesis of multiple sclerosis
Neurology 45 (6 Suppl 6): S33-S38 (1995-06)



1994

Spuler S.; Marx A.; Kirchner T.; Hohlfeld R.; Wekerle H.
Myogenesis in thymic transplants in the severe combined immunodeficient mouse model of myasthenia gravis. Differentiation of thymic myoid cells into striated muscle cells
American Journal of Pathology 145 (4): 766-770 (1994-10)



Spuler S.; Hohlfeld R.
Aktuelle Therapie der multiplen Sklerose: Mitoxantron [Current therapy of multiple sclerosis: mitoxantrone]
Nervenarzt 65 (2): 136-138 (1994-02)



1993

Meinl E.; Weber F.; Drexler K.; Morelle C.; Ott M.; Saruhan-Direskeneli G.; Goebels N.; Ertl B.; Jechart G.; Giegerich G.; Schoenbeck S.; Bannwarth W.; Wekerle H.; Hohlfeld R.
Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones
Journal of Clinical Investigation 92 (6): 2633-2643 (1993-12)



Schoenbeck S.; Padberg F.; Marx A.; Hohlfeld R.; Wekerle H.
Transplantation of myasthenia gravis thymus to SCID mice
Annals of the New York Academy of Sciences 681: 66-73 (1993-06-21)



1992

Schoenbeck S.; Padberg F.; Hohlfeld R.; Wekerle H.
Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis
Journal of Clinical Investigation 90 (1): 245-250 (1992-07)