Publications



2017

Rajewsky K.
George Klein: 1925-2016
Proceedings of the National Academy of Sciences of the United States of America : (2017-03-13)



2016

Wirtz T.; Weber T.; Kracker S.; Sommermann T.; Rajewsky K.; Yasuda T.
Mouse model for acute Epstein-Barr virus infection
Proceedings of the National Academy of Sciences of the United States of America 113 (48): 13821-13826 (2016-11-29)



Chu V.T.; Graf R.; Wirtz T.; Weber T.; Favret J.; Li X.; Petsch K.; Tran N.T.; Sieweke M.H.; Berek C.; Kuehn R.; Rajewsky K.
Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line
Proceedings of the National Academy of Sciences of the United States of America 113 (44): 12514-12519 (2016-11-01)



Derudder E.; Herzog S.; Labi V.; Yasuda T.; Koechert K.; Janz M.; Villunger A.; Schmidt-Supprian M.; Rajewsky K.
Canonical NF-{kappa}B signaling is uniquely required for the long-term persistence of functional mature B cells
Proceedings of the National Academy of Sciences of the United States of America 113 (18): 5065-5070 (2016-05-03)



Orlanski S.; Labi V.; Reizel Y.; Spiro A.; Lichtenstein M.; Levin-Klein R.; Koralov S.B.; Skversky Y.; Rajewsky K.; Cedar H.; Bergman Y.
Tissue-specific DNA demethylation is required for proper B-cell differentiation and function
Proceedings of the National Academy of Sciences of the United States of America 113 (18): 5018-5023 (2016-05-03)



Cho S.; Wu C.J.; Yasuda T.; Cruz L.O.; Khan A.A.; Lin L.L.; Nguyen D.T.; Miller M.; Lee H.M.; Kuo M.L.; Broide D.H.; Rajewsky K.; Rudensky A.Y.; Lu L.F.
miR-23~27~24 clusters control effector T cell differentiation and function
Journal of Experimental Medicine 213 (2): 235-249 (2016-02-08)



Farber D.L.; Netea M.G.; Radbruch A.; Rajewsky K.; Zinkernagel R.M.
Immunological memory: lessons from the past and a look to the future
Nature Reviews Immunology 16 (2): 124-128 (2016-02)



Wilhelm K.; Happel K.; Eelen G.; Schoors S.; Oellerich M.F.; Lim R.; Zimmermann B.; Aspalter I.M.; Franco C.A.; Boettger T.; Braun T.; Fruttiger M.; Rajewsky K.; Keller C.; Bruening J.C.; Gerhardt H.; Carmeliet P.; Potente M.
FOXO1 couples metabolic activity and growth state in the vascular endothelium
Nature 529 (7585): 216-220 (2016-01-14)



2015

Sander S.; Chu V.T.; Yasuda T.; Franklin A.; Graf R.; Calado D.P.; Li S.; Imami K.; Selbach M.; Di Virgilio M.; Bullinger L.; Rajewsky K.
PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones
Immunity 43 (6): 1075-1086 (2015-12-15)



Finkin S.; Yuan D.; Stein I.; Taniguchi K.; Weber A.; Unger K.; Browning J.L.; Goossens N.; Nakagawa S.; Gunasekaran G.; Schwartz M.E.; Kobayashi M.; Kumada H.; Berger M.; Pappo O.; Rajewsky K.; Hoshida Y.; Karin M.; Heikenwalder M.; Ben-Neriah Y.; Pikarsky E.
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
Nature Immunology 16 (12): 1235-1244 (2015-12)



Kuehn R.; Chu V.T.
Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9
Genome Biology 16 (1): 244 (2015-11-10)



Otipoby K.L.; Waisman A.; Derudder E.; Srinivasan L.; Franklin A.; Rajewsky K.
The B-cell antigen receptor integrates adaptive and innate immune signals
Proceedings of the National Academy of Sciences of the United States of America 112 (39): 12145-12150 (2015-09-29)



Murakawa Y.; Hinz M.; Mothes J.; Schuetz A.; Uhl M.; Wyler E.; Yasuda T.; Mastrobuoni G.; Friedel C.C.; Doelken L.; Kempa S.; Schmidt-Supprian M.; Bluethgen N.; Backofen R.; Heinemann U.; Wolf J.; Scheidereit C.; Landthaler M.
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-{kappa}B pathway
Nature Communications 6: 7367 (2015-07-14)



Chu V.T.; Weber T.; Wefers B.; Wurst W.; Sander S.; Rajewsky K.; Kuehn R.
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
Nature Biotechnology 33 (5): 543-548 (2015-05)



Sun A.; Novobrantseva T.I.; Coffre M.; Hewitt S.L.; Jensen K.; Skok J.A.; Rajewsky K.; Koralov S.B.
VH replacement in primary immunoglobulin repertoire diversification
Proceedings of the National Academy of Sciences of the United States of America 112 (5): E458-E466 (2015-02-03)



Ko M.; An J.; Pastor W.A.; Koralov S.B.; Rajewsky K.; Rao A.
TET proteins and 5-methylcytosine oxidation in hematological cancers
Immunological Reviews 263 (1): 6-21 (2015-01)



2014

Kreher S.; Bouhlel M.A.; Cauchy P.; Lamprecht B.; Li S.; Grau M.; Hummel F.; Koechert K.; Anagnostopoulos I.; Joehrens K.; Hummel M.; Hiscott J.; Wenzel S.S.; Lenz P.; Schneider M.; Kueppers R.; Scheidereit C.; Giefing M.; Siebert R.; Rajewsky K.; Lenz G.; Cockerill P.N.; Janz M.; Doerken B.; Bonifer C.; Mathas S.
Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma
Proceedings of the National Academy of Sciences of the United States of America 111 (42): E4513-E4522 (2014-10-21)



Authier H.; Billot K.; Derudder E.; Bordereaux D.; Riviere P.; Rodrigues-Ferreira S.; Nahmias C.; Baud V.
IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors
Proceedings of the National Academy of Sciences of the United States of America 111 (41): 14794-14799 (2014-10-14)



Hojer C.; Frankenberger S.; Strobl L.J.; Feicht S.; Djermanovic K.; Jagdhuber F.; Homig-Holzel C.; Ferch U.; Ruland J.; Rajewsky K.; Zimber-Strobl U.
B cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19
Cancer Research 74 (16): 4318-4328 (2014-08-15)



Heuberger J.; Kosel F.; Qi J.; Grossmann K.S.; Rajewsky K.; Birchmeier W.
Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine
Proceedings of the National Academy of Sciences of the United States of America 111 (9): 3472-3477 (2014-03-04)



Rajewsky K.
Michael S. Neuberger 1953-2013
Proceedings of the National Academy of Sciences of the United States of America 111 (8): 2862-2863 (2014-02-25)



Sheean M.E.; McShane E.; Cheret C.; Walcher J.; Mueller T.; Wulf-Goldenberg A.; Hoelper S.; Garratt A.N.; Krueger M.; Rajewsky K.; Meijer D.; Birchmeier W.; Lewin G.R.; Selbach M.; Birchmeier C.
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination
Genes & Development 28 (3): 290-303 (2014-02-01)



2012

Calado D.P.; Sasaki Y.; Godinho S.A.; Pellerin A.; Koechert K.; Sleckman B.P.; de Alboran I.M.; Janz M.; Rodig S.; Rajewsky K.
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
Nature Immunology 13 (11): 1092-1100 (2012-11)



Kaji T.; Ishige A.; Hikida M.; Taka J.; Hijikata A.; Kubo M.; Nagashima T.; Takahashi Y.; Kurosaki T.; Okada M.; Ohara O.; Rajewsky K.; Takemori T.
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory
Journal of Experimental Medicine 209 (11): 2079-2097 (2012-10-22)



Sander S.; Calado D.P.; Srinivasan L.; Koechert K.; Zhang B.; Rosolowski M.; Rodig S.J.; Holzmann K.; Stilgenbauer S.; Siebert R.; Bullinger L.; Rajewsky K.
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis
Cancer Cell 22 (2): 167-179 (2012-08-14)



Zhang B.; Kracker S.; Yasuda T.; Casola S.; Vannemann M.; Hoemig-Hoeltzel C.; Wang Z.; Derudder E.; Li S.; Chakraborty T.; Cotter S.E.; Koyama S.; Currie T.; Freeman G.J.; Kutok J.L.; Rodig S.J.; Dranoff G.; Rajewsky K.
Immune surveillance and therapy of lymphomas driven by Epstein-Barr-Virus protein LMP1 in a mouse model
Cell 148 (4): 739-751 (2012-02-17)



2010

Calado D.P.; Zhang B.; Srinivasan L.; Sasaki Y.; Seagal J.; Unitt C.; Rodig S.; Kutok J.; Tarakhovsky A.; Schmidt-Supprian M.; Rajewsky K.
Constitutive canonical NF-kappaB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma
Cancer Cell 18 (6): 580-589 (2010-12-14)



Kuchen S.; Resch W.; Yamane A.; Kuo N.; Li Z.; Chakraborty T.; Wei L.; Laurence A.; Yasuda T.; Peng S.; Hu-Li J.; Lu K.; Dubois W.; Kitamura Y.; Charles N.; Sun H.W.; Muljo S.; Schwartzberg P.L.; Paul W.E.; O'Shea J.; Rajewsky K.; Casellas R.
Regulation of microRNA expression and abundance during lymphopoiesis
Immunity 32 (6): 828-839 (2010-06-25)



2009

Srinivasan L.; Sasaki Y.; Calado D.P.; Zhang B.; Paik J.H.; DePinho R.A.; Kutok J.L.; Kearney J.F.; Otipoby K.L.; Rajewsky K.
PI3 kinase signals BCR-dependent mature B cell survival
Cell 139 (3): 573-586 (2009-10-30)



Xiao C.; Rajewsky K.
MicroRNA control in the immune system: basic principles
Cell 136 (1): 26-36 (2009-01-09)