Our faculty consists of a group of outstanding scientists from Berlin (MDC, Humboldt Universität (HU) and the Charité-Universitätsmedizin), Haifa (Technion - Israel Institute of Technology, TEC), and Jerusalem (The Hebrew University of Jerusalem, HUJI), whose research falls into the three main areas Cell Signaling, Gene Regulation, and Quantitative Biology.


Cell Signaling

To ensure the proper development and function of an organism, individual cells need to respond to changes in their environment, and to fulfill the demands of the tissue in which they operate. A number of SignGene laboratories are focusing their research on the signaling pathways regulating these processes. This includes the investigation of genes and signaling pathways that are key to development, normal physiological functions, and processes such as inflammation and cancerogenesis. The research is performed at several levels, from receptors at the cell surface to intracellular signaling pathways in the cytosol and the nucleus.


Photo: Juliane Brümmer (Rocks Lab)
Copyright MDC

Yinon Ben-Neriah, HUJI - Immunology and Cancer Research

Walter Birchmeier, MDC - Signal Transduction, Invasion and Metastasis of Epithelial Cells

Aaron Ciechanover, TEC - Protein Turnover

Gunnar Dittmar, MDC - Mass Spectrometry

Bernd Doerken, MDC and Charité - Haematology, Oncology and Tumorimmunology

Yaron Fuchs, TEC - Stem Cell Biology and Regenerative Medicine

Michael Glickman, TEC - Biochemical and Genetic Analysis of Proteasome Function

Gera Neufeld, TEC - Angiogenesis

Oliver Rocks, MDC - Spatio-Temporal Control of Rho GTPase Signaling

Clemens Schmitt, MDC and Charité - Cancer Genetics and Cellular Stress Response

Thomas Sommer, MDC - Intracellular Proteolysis

Ulrike Stein, MDC - Translational Oncology of Solid Tumors

Israel Vlodavsky, TEC - Cell Biology and Experimental Oncology




Gene Regulation

The identity and function of a cell is ultimately determined by its global gene expression pattern. Several SignGene groups focus on elucidating the fundamental molecular principles of gene regulation from the single gene level to global genetics networks. This research spans a variety of themes, including epigenetics, chromosomal structure dynamics, and genomic instability, as well as the occurrence of gene mutations leading to cancer and other diseases. Further molecular principles concern the function of protein ubiquitylation or SUMOylation in multiple pathways, including those controlling inflammation, neurodegeneration, or cancer.


Author: Claus Scheidereit
Copyright MDC

Yehudit Bergman, HUJI - Developmental Biology and Cancer Research

Howard Cedar, HUJI - DNA Methylation

Nir Friedman, HUJI - Chromatin and Transcriptional Regulation, Computational Systems Biology

Sebastian Kadener, HUJI - Molecular Neurobiology and RNA Metabolism

Batsheva Kerem, HUJI - Human Genetics

Achim Leutz, MDC - Cell Differentiation and Tumorigenesis

Koby Nahmias, HUJI - Microliver Technologies

Amir Orian, TEC - Genetic Networks in Development and Cancer

Klaus Rajewsky, MDC - Immune Regulation and Cancer

Nikolaus Rajewsky, MDC - Systems Biology of Gene Regulatory Elements

Ze'ev Ronai, TEC - Signal Transduction, Tumor Initiation and Maintenance

Claus Scheidereit, MDC - Signal Transduction in Tumor Cells



Quantitative Biology

The development of major technologies in recent years has enabled direct manipulation and probing of biological processes at the single-molecule and single-cell levels. These approaches probe the physical properties of diverse biological systems, resonating from the determination of the rate and fate of chemical reactions all the way up to the regulation of gene expression and cell differentiation. Researchers within this area combine experimental biological approaches with mathematical modeling and bioinformatic tools to elucidate gene regulatory and cell signaling modules networks.


Photo: Anja Schuetz (Heinemann Lab)
Copyright MDC

Nathalie Balaban, HUJI - Biological Biophysics

Oliver Daumke, MDC - Structure and Membrane Interaction of G-Proteins

Udo Heinemann, MDC - Macromolecular Structure and Interaction

Andreas Herrmann, HU - Molecular Biophysics

Stefan Kempa, MDC - Integrative Proteomics and Metabolomics Platform

Edda Klipp, HU - Theoretical Biophysics

Alexander Löwer, MDC and TU Darmstadt - Signaling Dynamics in Single Cells

Yael Mandel-Gutfreund, TEC - Computational Molecular Biology

Amit Meller, TEC - Single Molecule Biophysics and Nano-biotechnology

Matthias Selbach, MDC - Cell Signaling and Mass Spectrometry

Jana Wolf, MDC - Mathematical Modelling of Cellular Processes

Assaf Zemel, HUJI - Theoretical Biophysics


Harald Saumweber, HU - Cytogenetics


September 2017
Nir Friedman and Yaakov Nahmias receive award
The Rosetrees Trust Interdisciplinary Prize has been awarded to Nir Friedman and Yaakov Nahmias, SignGene faculty at Hebrew University, for a bold new model of human metabolism. For more information, please read here.

March 2017
SignGene Winter School in Eilat
This year's SignGene Winter School "Cellular Biology Through the Proteome and Single Cell Methods" took place in Eilat, Israel and included a visit to Petra in Jordan. Read more here.

June 2016
Nagarjuna R. Pamudurti receives JBC Fellowship
SignGene PhD student Nagarjuna Reddy Pamudurti has been awarded the JBC Doctoral Gold Fellowship by the Jerusalem Brain Community for his proposal: "Biogenesis and Function of circRNAs". Nagarjuna works on his PhD thesis in Sebastian Kadener's lab at the Hebrew University of Jerusalem (HUJI), in collaboration with Nikolaus Rajewsky at the MDC. For more information, please click here.

June 2016
Ulrike Stein is elected to MRS Board
MDC group leader and SignGene faculty member Ulrike Stein has been elected to the Board of the Metastasis Research Society (MRS).For more information, please click here

May 2016
Nir Friedman receives Humboldt Research Award
Israeli systems biologist, bioinformatician and SignGene faculty member Nir Friedman of the Hebrew University of Jerusalem (HUJI) is one of this year’s recipients of the prestigious Humboldt Research Award. For more information click here.

March 2016
Yinon Ben-Neriah receives Rappaport Prize
The 2016 Rappaport Prize goes to Yinon Ben-Neriah, a SignGene faculty member from the Hebrew University of Jerusalem. For more information click here.



Dr. Sandra Krull
Max Delbrück Center for Molecular Medicine
Robert-Rössle-Str 10
13125 Berlin

Phone: +49 30 9406 4205
Fax: +49 30 9406 2170