MACC1 induces cell motility, proliferation, and scattering in cell culture and metastasis in mouse models. It acts as transcription factor regulating e.g. Met expression, and also interacts with proteins via e.g. its SH3 domain or proline-rich motif. By microarrays we identified the MACC1 transcriptome. By HTS using the MACC1 promoter we identified first transcriptional MACC1 inhibitors. By MS we identified the MACC1 interactome and phospho-interactome for novel interventions.