Publications



2017

Buehler U.; Fleischer V.; Luessi F.; Rezk A.; Belikan P.; Graetz C.; Gollan R.; Wolf C.; Lutz J.; Bar-Or A.; Siffrin V.; Zipp F.
Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment
Multiple Sclerosis Journal 23 (4): 567-576 (2017-04-01)



2016

Schwab N.; Schneider-Hohendorf T.; Pignolet B.; Spadaro M.; Goerlich D.; Meinl I.; Windhagen S.; Tackenberg B.; Breuer J.; Canto E.; Kuempfel T.; Hohlfeld R.; Siffrin V.; Luessi F.; Posevitz-Fejfar A.; Montalban X.; Meuth S.G.; Zipp F.; Gold R.; Du Pasquier R.A.; Kleinschnitz C.; Jacobi A.; Comabella M.; Bertolotto A.; Brassat D.; Wiendl H.
PML risk stratification using anti-JCV antibody index and L-selectin
Multiple Sclerosis Journal 22 (8): 1048-1060 (2016-07)



Nemecek A.; Zimmermann H.; Ruebenthaler J.; Fleischer V.; Paterka M.; Luessi F.; Mueller-Forell W.; Zipp F.; Siffrin V.
Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression
Multiple Sclerosis Journal 22 (4): 483-493 (2016-04)



Luchtman D.; Gollan R.; Ellwardt E.; Birkenstock J.; Robohm K.; Siffrin V.; Zipp F.
In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity
Journal of Neurochemistry 136 (5): 971-980 (2016-03)



Paterka M.; Siffrin V.; Voss J.O.; Werr J.; Hoppmann N.; Gollan R.; Belikan P.; Bruttger J.; Birkenstock J.; Jung S.; Esplugues E.; Yogev N.; Flavell R.A.; Bopp T.; Zipp F.
Gatekeeper role of brain antigen-presenting CD11c(+) cells in neuroinflammation
EMBO Journal 35 (1): 89-101 (2016-01-04)



2015

Reuter E.; Weber J.; Paterka M.; Ploen R.; Breiderhoff T.; van Horssen J.; Willnow T.E.; Siffrin V.; Zipp F.
Role of sortilin in models of autoimmune neuroinflammation
Journal of Immunology 195 (12): 5762-5769 (2015-12-15)



Hoppmann N.; Graetz C.; Paterka M.; Poisa-Beiro L.; Larochelle C.; Hasan M.; Lill C.M.; Zipp F.; Siffrin V.
New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis
Brain 138 (Pt 4): 902-917 (2015-04)



Reuter E.; Gollan R.; Grohmann N.; Paterka M.; Salmon H.; Birkenstock J.; Richers S.; Leuenberger T.; Brandt A.U.; Kuhlmann T.; Zipp F.; Siffrin V.
Cross-recognition of a myelin peptide by CD8+ T cells in the CNS is not sufficient to promote neuronal damage
Journal of Neuroscience 35 (12): 4837-4850 (2015-03-25)



Walsh J.T.; Hendrix S.; Boato F.; Smirnov I.; Zheng J.; Lukens J.R.; Gadani S.; Hechler D.; Goelz G.; Rosenberger K.; Kammertoens T.; Vogt J.; Vogelaar C.; Siffrin V.; Radjavi A.; Fernandez-Castaneda A.; Gaultier A.; Gold R.; Kanneganti T.D.; Nitsch R.; Zipp F.; Kipnis J.
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
Journal of Clinical Investigation 125 (2): 699-714 (2015-02-02)



2014

Siffrin V.; Mueller-Forell W.; von Pein H.; Zipp F.
How to treat tumefactive demyelinating disease?
Multiple Sclerosis Journal 20 (5): 631-633 (2014-04)



2013

Ebner F.; Brandt C.; Thiele P.; Richter D.; Schliesser U.; Siffrin V.; Schueler J.; Stubbe T.; Ellinghaus A.; Meisel C.; Sawitzki B.; Nitsch R.
Microglial activation milieu controls regulatory T cell responses
Journal of Immunology 191 (11): 5594-5602 (2013-12-01)



Leuenberger T.; Paterka M.; Reuter E.; Herz J.; Niesner R.A.; Radbruch H.; Bopp T.; Zipp F.; Siffrin V.
The role of CD8(+) T cells and their local interaction with CD4(+) T cells in myelin oligodendrocyte glycoprotein(35-55)-induced experimental autoimmune encephalomyelitis
Journal of Immunology 191 (10): 4960-4968 (2013-11-15)



Jolivel V.; Luessi F.; Masri J.; Kraus S.H.P.; Hubo M.; Poisa-Beiro L.; Klebow S.; Paterka M.; Yogev N.; Tumani H.; Furlan R.; Siffrin V.; Jonuleit H.; Zipp F.; Waisman A.
Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis
Brain 136 (4): 1048-1066 (2013-04-01)



2011

Kipp M.; Gingele S.; Pott F.; Clarner T.; van der Valk P.; Denecke B.; Gan L.; Siffrin V.; Zipp F.; Dreher W.; Baumgartner W.; Pfeifenbring S.; Godbout R.; Amor S.; Beyer C.
BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions
Brain, Behavior and Immunity 25 (8): 1554-1568 (2011-11)



2010

Siffrin V.; Radbruch H.; Glumm R.; Niesner R.; Paterka M.; Herz J.; Leuenberger T.; Lehmann S.M.; Luenstedt S.; Rinnenthal J.L.; Laube G.; Luche H.; Lehnardt S.; Fehling H.J.; Griesbeck O.; Zipp F.
In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis
Immunity 33 (3): 424-436 (2010-09-24)



Herz J.; Zipp F.; Siffrin V.
Neurodegeneration in autoimmune CNS inflammation
Experimental Neurology 225 (1): 9-17 (2010-09)



Bendix I.; Pfueller C.F.; Leuenberger T.; Glezeva N.; Siffrin V.; Mueller Y.; Prozorovski T.; Hansen W.; Schulze-Topphoff U.; Loddenkemper C.; Zipp F.; Waiczies S.
MAPK3 deficiency drives autoimmunity via dendritic cell arming
European Journal of Immunology 40 (5): 1486-1495 (2010-05)



Siffrin V.; Vogt J.; Radbruch H.; Nitsch R.; Zipp F.
Multiple sclerosis - candidate mechanisms underlying CNS atrophy
Trends in Neurosciences 33 (4): 202-210 (2010-04)



Herz J.; Siffrin V.; Hauser A.E.; Brandt A.U.; Leuenberger T.; Radbruch H.; Zipp F.; Niesner R.A.
Expanding two-photon intravital microscopy to the infrared by means of optical parametric oscillator
Biophysical Journal 98 (4): 715-723 (2010-02-17)



2009

Meuth S.G.; Herrmann A.M.; Simon O.J.; Siffrin V.; Melzer N.; Bittner S.; Meuth P.; Langer H.F.; Hallermann S.; Boldakowa N.; Herz J.; Munsch T.; Landgraf P.; Aktas O.; Heckmann M.; Lessmann V.; Budde T.; Kieseier B.C.; Zipp F.; Wiendl H.
Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
Journal of Neuroscience 29 (49): 15397-15409 (2009-12-09)



Schulze-Topphoff U.; Prat A.; Prozorovski T.; Siffrin V.; Paterka M.; Herz J.; Bendix I.; Ifergan I.; Schadock I.; Mori M.A.; Van Horssen J.; Schroeter F.; Smorodchenko A.; Han M.H.; Bader M.; Steinman L.; Aktas O.; Zipp F.
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
Nature Medicine 15 (7): 788-793 (2009-07)



Siffrin V.; Brandt A.U.; Radbruch H.; Herz J.; Boldakowa N.; Leuenberger T.; Werr J.; Hahner A.; Schulze-Topphoff U.; Nitsch R.; Zipp F.
Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization
Brain 132 (5): 1247-1258 (2009-05)



2007

Siffrin V.; Brandt A.U.; Herz J.; Zipp F.
New insights into adaptive immunity in chronic neuroinflammation
Advances in Immunology 96: 1-40 (2007)



2005

Nogai A.; Siffrin V.; Bonhagen K.; Pfueller C.F.; Hohnstein T.; Volkmer-Engert R.; Brueck W.; Stadelmann C.; Kamradt T.
Lipopolysaccharide injection induces relapses of experimental autoimmune encephalomyelitis in nontransgenic mice via bystander activation of autoreactive CD4+ cells
Journal of Immunology 175 (2): 959-966 (2005-07-15)