NF-kappaB in organogenesis and disease
Our laboratory has a longstanding interest in elucidating the in vivo function of NF-κB in embryonic development and organogenesis. Understanding the role of NF-κB in normal cellular processes will serve as an important basis for studying the biochemistry of NF-κB activity in diseases, such as cancer or inflammation. In vivo NF-κB activity is also analysed in the context of other essential signaling pathways in development and disease, such as WNT/β-Catenin, TGF-β/BMP/Smad, SHH/GLI, and transcription factor p53, to eventually set up signaling networks. For our studies different loss-of-function, gain-of-function and reporter mouse models are used, as well as a broad range of histological and biochemical techniques.